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E Bucris
E Bucris
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
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Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
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A Beck
A Beck
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
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S Boura-Halfon
S Boura-Halfon
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
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R Isaac
R Isaac
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
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Y Vinik
Y Vinik
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
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T Rosenzweig
T Rosenzweig
Department of Molecular Biology and Nutritional Studies, Ariel University, Ariel, Israel
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S R Sampson
S R Sampson
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
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Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
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Y Zick
Y Zick
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
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1979 , Goldstein et al . 2005 a , Barazzoni et al . 2012 ) or superoxides ( Barazzoni et al . 2012 ). ROS, in turn, can increase oxidative stress and apoptosis in various cell types ( Furukawa et al . 2004 ), including pancreatic cells ( Robertson
Manjunath Ramanjaneya
Manjunath Ramanjaneya
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Bee K Tan
Bee K Tan
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Marcin Rucinski
Marcin Rucinski
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Mohamed Kawan
Mohamed Kawan
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Jiamiao Hu
Jiamiao Hu
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Jaspreet Kaur
Jaspreet Kaur
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Vanlata H Patel
Vanlata H Patel
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Ludwik K Malendowicz
Ludwik K Malendowicz
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Hanna Komarowska
Hanna Komarowska
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Hendrik Lehnert
Hendrik Lehnert
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Harpal S Randeva
Harpal S Randeva
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
Warwick Medical School, Interim Translational Research Institute, Department of Obstetrics and Gynaecology, Department of Histology and Embryology, Department of Endocrinology, 1st Medical Department, Department of Diabetes, Aston Medical Research Institute, University of Warwick, Coventry CV4 7AL, UK
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Introduction Optimal development of adrenal tissue requires a balance between cell proliferation and apoptosis (programmed cell death); apoptosis removes harmful, damaged or unwanted cells. Within the adrenal gland, constant dynamic changes control
Xiwen Xiong
Xiwen Xiong
Department of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China
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Xupeng Sun
Xupeng Sun
Department of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China
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Qingzhi Wang
Qingzhi Wang
Department of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China
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Xinlai Qian
Xinlai Qian
Department of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China
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Yang Zhang
Yang Zhang
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
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Xiaoyan Pan
Xiaoyan Pan
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
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Department of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
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X Charlie Dong
X Charlie Dong
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
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-Weir 2004 ). Acute exposure to elevated free fatty acids (FFA) increases β-cell proliferation and insulin secretion, whereas prolonged exposure to FFA inhibits insulin secretion and induces β-cell apoptosis ( Shimabukuro et al . 1998 , Biden et al . 2004
Yeon Jean Cho
Yeon Jean Cho
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
Department of Obstetrics and Gynecology, Dong-A University, College of Medicine, Busan, Republic of Korea
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Department of Obstetrics and Gynecology, Dong-A University, College of Medicine, Busan, Republic of Korea
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Jiyeun E Lee
Jiyeun E Lee
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
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Mi Jin Park
Mi Jin Park
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
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Bert W O’Malley
Bert W O’Malley
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas, USA
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Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas, USA
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Sang Jun Han
Sang Jun Han
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas, USA
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Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas, USA
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-mediated apoptosis and enhances inflammasome-mediated inflammatory signaling in endometriotic lesions for their survival ( Han et al . 2012 , 2015 ). Collectively, these recent findings led us to hypothesize that the SRC-1 isoform/ERβ axis should be a new molecular
Suwattanee Kooptiwut
Suwattanee Kooptiwut
Department of Physiology, Department of Anatomy, Division of Molecular Medicine, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
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Wanthanee Hanchang
Wanthanee Hanchang
Department of Physiology, Department of Anatomy, Division of Molecular Medicine, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
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Namoiy Semprasert
Namoiy Semprasert
Department of Physiology, Department of Anatomy, Division of Molecular Medicine, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
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Mutita Junking
Mutita Junking
Department of Physiology, Department of Anatomy, Division of Molecular Medicine, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
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Thawornchai Limjindaporn
Thawornchai Limjindaporn
Department of Physiology, Department of Anatomy, Division of Molecular Medicine, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
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Pa-thai Yenchitsomanus
Pa-thai Yenchitsomanus
Department of Physiology, Department of Anatomy, Division of Molecular Medicine, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
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of calcium and to stimulate insulin secretion in isolated pancreatic islets ( Grillo et al . 2005 ). Moreover, testosterone replacement conferred protection against pancreatic β-cell apoptosis in STZ-diabetic male rats ( Palomar-Morales et al . 2010
V A Nunes
V A Nunes
School of Arts, Institute of Biomedical Sciences, Department of Biochemistry of Federal University of Sao Paulo, Institute of Clinical Biochemistry, Sciences and Humanities
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E P Portioli-Sanches
E P Portioli-Sanches
School of Arts, Institute of Biomedical Sciences, Department of Biochemistry of Federal University of Sao Paulo, Institute of Clinical Biochemistry, Sciences and Humanities
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M P Rosim
M P Rosim
School of Arts, Institute of Biomedical Sciences, Department of Biochemistry of Federal University of Sao Paulo, Institute of Clinical Biochemistry, Sciences and Humanities
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M S Araujo
M S Araujo
School of Arts, Institute of Biomedical Sciences, Department of Biochemistry of Federal University of Sao Paulo, Institute of Clinical Biochemistry, Sciences and Humanities
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P Praxedes-Garcia
P Praxedes-Garcia
School of Arts, Institute of Biomedical Sciences, Department of Biochemistry of Federal University of Sao Paulo, Institute of Clinical Biochemistry, Sciences and Humanities
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M M R Valle
M M R Valle
School of Arts, Institute of Biomedical Sciences, Department of Biochemistry of Federal University of Sao Paulo, Institute of Clinical Biochemistry, Sciences and Humanities
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L P Roma
L P Roma
School of Arts, Institute of Biomedical Sciences, Department of Biochemistry of Federal University of Sao Paulo, Institute of Clinical Biochemistry, Sciences and Humanities
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C Hahn
C Hahn
School of Arts, Institute of Biomedical Sciences, Department of Biochemistry of Federal University of Sao Paulo, Institute of Clinical Biochemistry, Sciences and Humanities
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E Gurgul-Convey
E Gurgul-Convey
School of Arts, Institute of Biomedical Sciences, Department of Biochemistry of Federal University of Sao Paulo, Institute of Clinical Biochemistry, Sciences and Humanities
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S Lenzen
S Lenzen
School of Arts, Institute of Biomedical Sciences, Department of Biochemistry of Federal University of Sao Paulo, Institute of Clinical Biochemistry, Sciences and Humanities
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A K Azevedo-Martins
A K Azevedo-Martins
School of Arts, Institute of Biomedical Sciences, Department of Biochemistry of Federal University of Sao Paulo, Institute of Clinical Biochemistry, Sciences and Humanities
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, considering that apoptosis is involved in the pathophysiology of type 1 and 2 diabetes and also contributes to the involution of the β-cell mass in the postpartum phase ( Scaglia et al . 1995 ), we first proposed the hypothesis that progesterone might be
Ying Wang
Ying Wang
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Xiao-Hui Wang
Xiao-Hui Wang
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Deng-Xuan Fan
Deng-Xuan Fan
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Yuan Zhang
Yuan Zhang
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Ming-Qing Li
Ming-Qing Li
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Hai-Xia Wu
Hai-Xia Wu
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Li-Ping Jin
Li-Ping Jin
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Department of Reproductive Medicine, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, No. 413, Zhaozhou Road, Shanghai 200011, China
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, unprocessed pro-β-NGF mediates apoptosis of neuron ( Lee et al . 2001 ). PCs have been shown to be involved in a wide range of processes including embryogenesis, homeostasis, and in diseases, such as Alzheimer's disease, tumorigenesis, and infections
J N Zamarbide Losada
J N Zamarbide Losada
Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK
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E Sulpice
E Sulpice
Université Grenoble Alpes, CEA, INSERM, BIG, BGE, Grenoble, France
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S Combe
S Combe
Université Grenoble Alpes, CEA, INSERM, BIG, BGE, Grenoble, France
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G S Almeida
G S Almeida
Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK
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D A Leach
D A Leach
Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK
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J Choo
J Choo
Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK
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L Protopapa
L Protopapa
Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK
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M P Hamilton
M P Hamilton
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
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S McGuire
S McGuire
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
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X Gidrol
X Gidrol
Université Grenoble Alpes, CEA, INSERM, BIG, BGE, Grenoble, France
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C L Bevan
C L Bevan
Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK
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C E Fletcher
C E Fletcher
Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK
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) has been a major hurdle to curative BC treatment. Few efficacious treatment options are available for the treatment of resistant disease, and hence, the discovery of new therapies is highly desirable. Apoptosis is a process of programmed cell death
Weihua Liu
Weihua Liu
Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
Department of Pediatrics, First Hospital of Xi’an, Xi’an, Shaanxi, China
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Department of Pediatrics, First Hospital of Xi’an, Xi’an, Shaanxi, China
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Yuqiang Ji
Yuqiang Ji
Department of Cardiovascular Medicine, First Hospital of Xi’an, Xi’an, Shaanxi, China
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Haiping Chu
Haiping Chu
Department of Pediatrics, First Hospital of Xi’an, Xi’an, Shaanxi, China
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Mo Wang
Mo Wang
Department of Pediatrics, Maternal and Child Health Hospital of Chang’an District, Xi’an, Shaanxi, China
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Bin Yang
Bin Yang
Department of Pediatrics, Maternal and Child Health Hospital of Chang’an District, Xi’an, Shaanxi, China
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Chunyan Yin
Chunyan Yin
Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
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of leukocytes ( Hu et al. 2008 ). Endothelial cell damage or dysfunction can lead to increased vascular wall permeability, aggravated inflammatory response, and trigger thrombosis. Endothelial cell apoptosis is the main form of endothelial injury
Amy Hughes
Amy Hughes
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Darling Rojas-Canales
Darling Rojas-Canales
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Chris Drogemuller
Chris Drogemuller
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Nicolas H Voelcker
Nicolas H Voelcker
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Shane T Grey
Shane T Grey
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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P T H Coates
P T H Coates
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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, enzymatic and mechanical injury and immune-mediated rejection that contribute to islet allograft failure in the early post-transplant period ( Robertson 2004 , Tjernberg et al . 2008 , Walters et al . 2013 ). Thus, inhibition of islet apoptosis is an
