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CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway
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CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
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2014 , Contreras et al . 2016 b ), is responsible for a significant increase in total energy expenditure ( Shabalina et al . 2013 ). Thus, stimulation of browning has therapeutic potential to promote body fat reduction ( Yoneshiro et al . 2013
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I.N.B.B. – Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy
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I.N.B.B. – Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy
Gynecologic Endocrinology Research Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy
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between FXR- and TGR5-mediated pathways induced by INT-767. The results show that INT-767 treatment improves several MetS features, including insulin resistance, NASH and visceral adipose tissue dysfunction, remodeling visceral fat toward brown phenotype
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Nantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, Institute of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong University, Nantong, China
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(WAT) and brown fat tissue (BAT). WAT is an organ for storing excess energy ( Gesta et al. 2007 , Lo & Sun 2013 , Nedergaard & Cannon 2014 , Yu et al. 2015 ); on the contrary, BAT is involved in thermogenesis-mediated energy consumption ( Cannon
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interscapular as well as subscapular BAT DNA ( Fig. 3C ), as expected from the around 50% adipocyte content of fat depots ( Kang et al. 2014 ). This reduction is in the range of other studies using the Ucp1-Cre construct for targeting brown adipocytes in BAT
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recent data have confirmed that BAT oxidative metabolism contributes significantly to energy expenditure ( Ouellet et al . 2012 ). The classical view of brown and white fat cells was modified in 2010 by a publication of the Cannon/Nedergaard group
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Adipose tissue browning and whitening A hallmark feature of adipose tissue browning is the induction of thermogenically active adipocytes in white fat depots. These adipocytes are often referred to as beige or brite (brown in white) cells and
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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respiratory rate in differentiation media. Preadipocytes isolated from brown fat biopsies were differentiated in 0, 1.0, or 10 μM dexamethasone for 9 days in dedicated culture plates provided by the manufacturer that are required for undertaking measurement of
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK
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al. 2018 b ). Adipose tissue is comprised of at least three different sub-types, that is, brown, beige or white fat ( Kalinovich et al. 2017 ). These are primarily distinguished by the lack of, or by the relative abundance of uncoupling protein
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
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Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
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Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
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Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
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development of insulin resistance in both white and brown adipocytes. Research design and methods Isolation and characterization of hMSC from liposuction sample Liposuction samples were obtained from patient undergoing fat reduction surgery with
CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
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CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
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as leptin, in brown fat and the low expression of pro-inflammatory cytokines known to be released by WAT (e.g. tumour necrosis factor-α; TNFα) ( Cannon & Nedergaard 2004 ) may have also contributed to a somewhat historically neglected research on the