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Jennifer M Ikle Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA

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Anna L Gloyn Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
Stanford Diabetes Research Center, Stanford University, Stanford, California, USA

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Introduction It was in the 1930s, after the discovery and first use of insulin, that Harold Percival Himsworth first made the distinction between type 1 and type 2 diabetes ( Bryder & Harper 2013 ). However, it was not until the 1970s

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Elliott P Brooks Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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Lori Sussel Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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because of their causal association with diabetes mellitus. For this reason, α cell research has been somewhat neglected, leaving many unanswered questions about α cell biology. However, in recent years, α cell research has gained momentum due to the

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J Cantley School of Medicine, University of Dundee, Dundee, United Kingdom of Great Britain and Northern Ireland

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D L Eizirik ULB Center for Diabetes Research, Université Libre de Bruxelles Faculté de Médecine, Bruxelles, Belgium

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E Latres JDRF International, New York, NY, USA

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C M Dayan Cardiff University School of Medicine, Cardiff, United Kingdom of Great Britain and Northern Ireland

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the JDRF-DiabetesUK-INNODIA-nPOD Stockholm Symposium 2022

Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease with a strong inflammatory component that results from the interaction between predisposing genes and environmental factors (e.g. viral infections and diet). This interaction

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Karsten Suhre Department of Physiology and Biophysics, Institute of Bioinformatics and Systems Biology, Qatar Foundation – Education City, Weill Cornell Medical College – Qatar, PO Box 24144, Doha, Qatar
Department of Physiology and Biophysics, Institute of Bioinformatics and Systems Biology, Qatar Foundation – Education City, Weill Cornell Medical College – Qatar, PO Box 24144, Doha, Qatar

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body, as they are revealed by studies of metabolic profiling in diabetes ( German et al . 2005 , Wenk 2005 ). Application of metabolomics approaches to metabolic disorders, especially diabetes, is particularly promising since deregulations of

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Haiyong Chen Li Ka Sing Faculty of Medicine, Department of Medicine and Therapeutics, Centre for Biosystems and Genome Network Medicine, Department of Clinical Oncology, School of Chinese Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

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Hui-Yao Lan Li Ka Sing Faculty of Medicine, Department of Medicine and Therapeutics, Centre for Biosystems and Genome Network Medicine, Department of Clinical Oncology, School of Chinese Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

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Dimitrios H Roukos Li Ka Sing Faculty of Medicine, Department of Medicine and Therapeutics, Centre for Biosystems and Genome Network Medicine, Department of Clinical Oncology, School of Chinese Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

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William C Cho Li Ka Sing Faculty of Medicine, Department of Medicine and Therapeutics, Centre for Biosystems and Genome Network Medicine, Department of Clinical Oncology, School of Chinese Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

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Introduction Diabetes mellitus (DM) affects 347 million people worldwide. The World Health Organization predicts that diabetes-related deaths could double between 2005 and 2030. The research conducted by American Diabetes Association estimated that

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Elizabeth S Barrie The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Mels Lodder The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Paul H Weinreb The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Jill Buss The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Amer Rajab The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Christopher Adin The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Qing-Sheng Mi The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Gregg A Hadley The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Introduction Type 1 diabetes is a T cell-mediated autoimmune disease caused by the destruction of insulin-producing β cells of the islets of Langerhans in the pancreas, resulting in a hyperglycemic state. Non-obese diabetic (NOD) mice (NOD

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Emma Ahlqvist Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden

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Rashmi B Prasad Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden
Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland

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Leif Groop Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden
Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland

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Heterogeneity of diabetes Present official classification of diabetes Diabetes, particularly type 2 diabetes (T2D), is one of the fastest increasing diseases worldwide. However, under the term T2D, we lump together diseases with varying

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James E Bowe Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Zara J Franklin Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Astrid C Hauge-Evans Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Aileen J King Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Shanta J Persaud Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Peter M Jones Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Introduction The incidence of diabetes mellitus, particularly obesity-related type 2 diabetes, is increasing at an alarming rate in the developed world, and this epidemic is driving numerous research programmes into the causes of, and new treatment

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Johan G Eriksson Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Folkhälsan Research Center, University of Helsinki, Helsinki, Finland
Department of Obstetrics and Gynecology, National University of Singapore, Yong Loo Lin School of Medicine, Singapore, Singapore

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Type 2 diabetes Type 2 diabetes (T2D) is a major, rapidly increasing global public health challenge. The number of adults with diabetes is estimated to have increased from 108 to 422 million between 1980 and 2014 making it one of the fastest

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Richard W Nelson Department of Medicine and Epidemiology, Clinic for Small Animal Internal Medicine, School of Veterinary Medicine, University of California, Davis, California 95616, USA

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Claudia E Reusch Department of Medicine and Epidemiology, Clinic for Small Animal Internal Medicine, School of Veterinary Medicine, University of California, Davis, California 95616, USA

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Introduction Diabetes mellitus is a common disorder in dogs and cats, with a reported hospital prevalence rate of ∼0.4–1.2%. Classic clinical signs of diabetes include polyuria, polydipsia, polyphagia, and weight loss. Clinical signs do not develop

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