Plasma steroid profiling and response to trophins to illustrate intra-adrenal dynamics

F McManus

F McManus
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R Fraser

R Fraser
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E Davies

E Davies
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J M C Connell

J M C Connell Institute of Cardiovascular and Medical Sciences, College of Medicine, University of Glasgow, Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK

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E M Freel

E M Freel
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series of enzyme-catalysed reactions. The efficiency of each enzyme may vary, for example, in a genetically determined manner, so that each step in the pathway may become rate limiting to a greater or lesser extent. This phenomenon is well documented in a

Article Type:: Research Article

DOI:: https://doi.org/10.1530/JOE-14-0561

Volume/Issue:: Volume 224: Issue 2

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Dapagliflozin attenuates renal gluconeogenic enzyme expression in obese rats

Myat Theingi Swe

Myat Theingi Swe Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Department of Physiology, University of Medicine 2, Yangon, Myanmar

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Laongdao Thongnak

Laongdao Thongnak Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Krit Jaikumkao

Krit Jaikumkao Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Anchalee Pongchaidecha

Anchalee Pongchaidecha Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Varanuj Chatsudthipong

Varanuj Chatsudthipong Research Center of Transport Protein for Medical Innovation, Faculty of Science, Mahidol University, Bangkok, Thailand

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Anusorn Lungkaphin

Anusorn Lungkaphin Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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. 2002 ). Therefore, the contribution of renal gluconeogenesis to plasma glucose levels should not be neglected. The rate-limiting enzymes for gluconeogenesis are phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase) and fructose-1

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DOI:: https://doi.org/10.1530/JOE-19-0480

Volume/Issue:: Volume 245: Issue 2

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Expression of steroidogenic enzymes in human sebaceous glands

Takayoshi Inoue

Takayoshi Inoue Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan
Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Yasuhiro Miki

Yasuhiro Miki Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Shingo Kakuo

Shingo Kakuo Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Akira Hachiya

Akira Hachiya Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Takashi Kitahara

Takashi Kitahara Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Setsuya Aiba

Setsuya Aiba Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Christos C Zouboulis

Christos C Zouboulis Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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Hironobu Sasano

Hironobu Sasano Departments of Pathology, Dermatology, Biological Science Laboratories, Departments of Dermatology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

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enzymes have been reported for a variety of peripheral tissues ( Belanger et al . 2002 , Yanase et al . 2003 ), which indicates that sex steroids are locally biosynthesized in an ‘intracrine’ manner. This peripheral production of sex steroids has been

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DOI:: https://doi.org/10.1530/JOE-14-0323

Volume/Issue:: Volume 222: Issue 3

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Both N-terminal and C-terminal regions of steroid sulfatase are important for enzyme activity

T Sugawara

T Sugawara Department of Biochemistry and
Department of Obstetrics & Gynaecology, Hokkaido Graduate School of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo 060-8638, Japan
Department of Animal Science, Faculty of Agriculture, Kobe University, Kobe 657-8501, Japan

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E Nomura

E Nomura Department of Biochemistry and
Department of Obstetrics & Gynaecology, Hokkaido Graduate School of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo 060-8638, Japan
Department of Animal Science, Faculty of Agriculture, Kobe University, Kobe 657-8501, Japan

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N Hoshi

N Hoshi Department of Biochemistry and
Department of Obstetrics & Gynaecology, Hokkaido Graduate School of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo 060-8638, Japan
Department of Animal Science, Faculty of Agriculture, Kobe University, Kobe 657-8501, Japan

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Introduction Steroid sulfatase (STS) (EC 3.I.6.2) is present in various mammalian tissues, such as the liver, ovary and testis, and is especially abundant in the placenta ( Warren & French 1965 ). This enzyme is a membrane

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DOI:: https://doi.org/10.1677/joe.1.06417

Volume/Issue:: Volume 188: Issue 2

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Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system

Robson A S Santos

Robson A S Santos Departments of Physiology and Biophysics, Morphology, Department of Biochemistry and Molecular Biology, Max‐Delbrück Center for Molecular Medicine (MDC), Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

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Anderson J Ferreira

Anderson J Ferreira Departments of Physiology and Biophysics, Morphology, Department of Biochemistry and Molecular Biology, Max‐Delbrück Center for Molecular Medicine (MDC), Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

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Thiago Verano-Braga

Thiago Verano-Braga Departments of Physiology and Biophysics, Morphology, Department of Biochemistry and Molecular Biology, Max‐Delbrück Center for Molecular Medicine (MDC), Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Departments of Physiology and Biophysics, Morphology, Department of Biochemistry and Molecular Biology, Max‐Delbrück Center for Molecular Medicine (MDC), Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

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Michael Bader

Michael Bader Departments of Physiology and Biophysics, Morphology, Department of Biochemistry and Molecular Biology, Max‐Delbrück Center for Molecular Medicine (MDC), Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

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Introduction Santos et al . (1988) described the formation of the heptapeptide angiotensin (Ang)-(1–7) from Ang I by an Ang-converting enzyme (ACE)-independent pathway. In the same year, Schiavone et al . (1988) published the first report of a

Article Type:: Research Article

DOI:: https://doi.org/10.1530/JOE-12-0341

Volume/Issue:: Volume 216: Issue 2

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Recycling glucocorticoids: therapeutic implications of the 11β-HSD1 enzyme system

Kevin H Tsai

Kevin H Tsai ANZAC Research Institute, Concord Clinical School, University of Sydney, Sydney, New South Wales, Australia

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Mark S Cooper

Mark S Cooper ANZAC Research Institute, Concord Clinical School, University of Sydney, Sydney, New South Wales, Australia

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. Thus prednisone, cortisone and DHC are inactive and require modification at the 11beta position to have glucocorticoid action ( Fig. 1 ). The intracellular enzymes that mediate this modification are the 11β-hydroxysteroid dehydrogenases (11β

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-22-0289

Volume/Issue:: Volume 258: Issue 3

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Cafeteria diet inhibits insulin clearance by reduced insulin-degrading enzyme expression and mRNA splicing

P Brandimarti

P Brandimarti Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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J M Costa-Júnior

J M Costa-Júnior Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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S M Ferreira

S M Ferreira Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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A O Protzek

A O Protzek Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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G J Santos

G J Santos Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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E M Carneiro

E M Carneiro Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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A C Boschero

A C Boschero Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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L F Rezende

L F Rezende Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), PO Box 6109, Campinas, SP, CEP 13083-865, Brazil

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. 2008 ). Also, in hepatocytes, insulin degradation is mediated primarily by the insulin-degrading enzyme (IDE; Valera Mora et al . 2003 ). While increased insulin secretion and reduced insulin sensitivity have been extensively described and studied in

Article Type:: Research Article

DOI:: https://doi.org/10.1530/JOE-13-0177

Volume/Issue:: Volume 219: Issue 2

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Changes in mRNAs encoding steroidogenic acute regulatory protein, steroidogenic enzymes and receptors for gonadotropins during spermatogenesis in rainbow trout testes

M Kusakabe

M Kusakabe School of Aquatic and Fishery Sciences, University of Washington, 1140 Boat Street NE, Seattle, Washington 98195-5020, USA
Department of Zoology, University of Otago, PO Box 56, Dunedin, New Zealand
Northwest Fisheries Science Center, NOAA Fisheries, Seattle, Washington 98112, USA
Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA

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I Nakamura

I Nakamura School of Aquatic and Fishery Sciences, University of Washington, 1140 Boat Street NE, Seattle, Washington 98195-5020, USA
Department of Zoology, University of Otago, PO Box 56, Dunedin, New Zealand
Northwest Fisheries Science Center, NOAA Fisheries, Seattle, Washington 98112, USA
Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA

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J Evans

J Evans School of Aquatic and Fishery Sciences, University of Washington, 1140 Boat Street NE, Seattle, Washington 98195-5020, USA
Department of Zoology, University of Otago, PO Box 56, Dunedin, New Zealand
Northwest Fisheries Science Center, NOAA Fisheries, Seattle, Washington 98112, USA
Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA

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P Swanson

P Swanson School of Aquatic and Fishery Sciences, University of Washington, 1140 Boat Street NE, Seattle, Washington 98195-5020, USA
Department of Zoology, University of Otago, PO Box 56, Dunedin, New Zealand
Northwest Fisheries Science Center, NOAA Fisheries, Seattle, Washington 98112, USA
Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA

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G Young

G Young School of Aquatic and Fishery Sciences, University of Washington, 1140 Boat Street NE, Seattle, Washington 98195-5020, USA
Department of Zoology, University of Otago, PO Box 56, Dunedin, New Zealand
Northwest Fisheries Science Center, NOAA Fisheries, Seattle, Washington 98112, USA
Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA

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. In mammals, FSH and LH primarily regulate steroid production through control of steroidogenic enzyme gene expression ( Richards 1994 ). Binding of FSH or LH to their specific cell-surface receptors leads to the production of second messenger molecules

Article Type:: Research Article

DOI:: https://doi.org/10.1677/joe.1.06684

Volume/Issue:: Volume 189: Issue 3

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Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men

Karine Blouin

Karine Blouin Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2
Department of surgery, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2

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Christian Richard

Christian Richard Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2
Department of surgery, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2

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Gaétan Brochu

Gaétan Brochu Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2
Department of surgery, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2

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Frédéric-Simon Hould

Frédéric-Simon Hould Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2
Department of surgery, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2

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Stéfane Lebel

Stéfane Lebel Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2
Department of surgery, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2

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Simon Marceau

Simon Marceau Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2
Department of surgery, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2

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Simon Biron

Simon Biron Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2
Department of surgery, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2

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Van Luu-The

Van Luu-The Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2
Department of surgery, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2

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André Tchernof

André Tchernof Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2
Department of surgery, Laval University, 2705 Laurier Boulevard (T3-67), Québec, Québec, Canada G1V 4G2

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metabolically active organ which possesses endocrine, paracrine, and autocrine hormonal properties is increasingly recognized ( Mohamed-Ali et al. 1998 , Kershaw & Flier 2004 ). In this regard, several steroid-converting enzymes involved in local sex steroid

Article Type:: Research Article

DOI:: https://doi.org/10.1677/joe.1.06365

Volume/Issue:: Volume 191: Issue 3

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Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Manuel D Gahete

Manuel D Gahete Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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David Rincón-Fernández

David Rincón-Fernández Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Alicia Villa-Osaba

Alicia Villa-Osaba Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Daniel Hormaechea-Agulla

Daniel Hormaechea-Agulla Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Alejandro Ibáñez-Costa

Alejandro Ibáñez-Costa Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Antonio J Martínez-Fuentes

Antonio J Martínez-Fuentes Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Francisco Gracia-Navarro

Francisco Gracia-Navarro Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Justo P Castaño

Justo P Castaño Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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Raúl M Luque

Raúl M Luque Department of Cell Biology, Physiology and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa (C6), Planta 3, University of Córdoba, 14014-Córdoba; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba; Reina Sofia University Hospital, Córdoba; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Córdoba, Spain

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acylation status, the peptide can be termed unacylated ghrelin (UAG) or acylated-ghrelin (AG), AG being the initially identified peptide ( Kojima et al . 1999 ), which corresponds to the active peptide able to bind its canonical receptor, GHSR1a. The enzyme

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-13-0391

Volume/Issue:: Volume 220: Issue 1

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Plasma steroid profiling and response to trophins to illustrate intra-adrenal dynamics

Dapagliflozin attenuates renal gluconeogenic enzyme expression in obese rats

Expression of steroidogenic enzymes in human sebaceous glands

Both N-terminal and C-terminal regions of steroid sulfatase are important for enzyme activity

Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system

Recycling glucocorticoids: therapeutic implications of the 11β-HSD1 enzyme system

Cafeteria diet inhibits insulin clearance by reduced insulin-degrading enzyme expression and mRNA splicing

Changes in mRNAs encoding steroidogenic acute regulatory protein, steroidogenic enzymes and receptors for gonadotropins during spermatogenesis in rainbow trout testes

Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

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