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M Merle Elloso Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
Women’s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA

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Kristen Phiel Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
Women’s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA

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Ruth A Henderson Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
Women’s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA

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Heather A Harris Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
Women’s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA

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Steven J Adelman Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
Women’s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA

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that estrogen has biphasic effects on cytokine secretion ( Gilmore et al. 1997 ). These results suggest that estrogens could potentially alter disease through direct binding to estrogen receptors (ERs) on pathogenic T cells. Estrogen action is

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06063
Volume/Issue:
Volume 185: Issue 2
Free access
H H Farman Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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K L Gustafsson Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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P Henning Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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L Grahnemo Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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V Lionikaite Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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S Movérare-Skrtic Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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J Wu Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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H Ryberg Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden

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A Koskela Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland

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J Tuukkanen Unit of Cancer Research and Translational Medicine, MRC Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland

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E R Levin Division of Endocrinology, Departments of Medicine and Biochemistry, University of California, Irvine, California, USA
The Long Beach VA Medical Center, Long Beach, California, USA

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C Ohlsson Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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M K Lagerquist Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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in order to find bone-specific treatments for male osteoporosis. Estrogen receptors (ERs) mediate the bone-protective effects of estrogens, and we and others have demonstrated that ERα is the main mediator of these protective effects on the skeleton

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0406
Volume/Issue:
Volume 239: Issue 3
Restricted access
E E Connor Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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D L Wood Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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T S Sonstegard Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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A F da Mota Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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G L Bennett Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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J L Williams Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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A V Capuco Bovine Functional Genomics Laboratory, USDA-ARS, Beltsville, Maryland 20705, USA
EMBRAPA-National Dairy Cattle Research Center, Juiz de Fora-MG, 36038-330, Brazil
Production Systems Research, US Meat Animal Research Center, Clay Center, Nebraska 68933, USA
Roslin Institute, Midlothian EH25 9PS, Scotland, UK

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replacement studies in rats ( Lyons 1958 ) and recent estrogen receptor (ER) knockout studies in mice ( Bocchinfuso & Korach 1997 ) indicated that estrogens are essential for the normal mammary ductal growth that occurs from birth to sexual maturity. In

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06139
Volume/Issue:
Volume 185: Issue 3
Free access
Shan-Jin Wang Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China

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Xin-Feng Li Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China

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Lei-Sheng Jiang Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China

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Li-Yang Dai Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China

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several growth factors and hormones. One of the key regulators of endochondral bone development is estrogen ( Perry et al . 2008 ). Estrogen exerts its effect via traditional genomic interactions with two nuclear receptors, namely estrogen receptor α (ERα

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0353
Volume/Issue:
Volume 213: Issue 2
Free access
Terhi J Heino Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Q2:08, SE-171 76 Stockholm, Sweden

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Andrei S Chagin Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Q2:08, SE-171 76 Stockholm, Sweden

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Lars Sävendahl Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Q2:08, SE-171 76 Stockholm, Sweden

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Introduction Estrogen (17β-estradiol) is an important regulator of bone metabolism, which is illustrated by the low bone mass phenotype in a man carrying a mutation in estrogen receptor-α (ERα; Smith et al . 1994 ) and in individuals with a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0629
Volume/Issue:
Volume 197: Issue 2
Free access
Hyun Joon Kim Division of Clinical and Reproductive Sciences, Department of Anatomy and Neurobiology, Animal Sciences, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, INSERM, ULP, College de France) and Institut Clinique de la Souris, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
Division of Clinical and Reproductive Sciences, Department of Anatomy and Neurobiology, Animal Sciences, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, INSERM, ULP, College de France) and Institut Clinique de la Souris, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA

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Mary C Gieske Division of Clinical and Reproductive Sciences, Department of Anatomy and Neurobiology, Animal Sciences, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, INSERM, ULP, College de France) and Institut Clinique de la Souris, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
Division of Clinical and Reproductive Sciences, Department of Anatomy and Neurobiology, Animal Sciences, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, INSERM, ULP, College de France) and Institut Clinique de la Souris, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA

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Susan Hudgins Division of Clinical and Reproductive Sciences, Department of Anatomy and Neurobiology, Animal Sciences, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, INSERM, ULP, College de France) and Institut Clinique de la Souris, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA

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Beob Gyun Kim Division of Clinical and Reproductive Sciences, Department of Anatomy and Neurobiology, Animal Sciences, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, INSERM, ULP, College de France) and Institut Clinique de la Souris, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA

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Andree Krust Division of Clinical and Reproductive Sciences, Department of Anatomy and Neurobiology, Animal Sciences, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, INSERM, ULP, College de France) and Institut Clinique de la Souris, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA

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Pierre Chambon Division of Clinical and Reproductive Sciences, Department of Anatomy and Neurobiology, Animal Sciences, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, INSERM, ULP, College de France) and Institut Clinique de la Souris, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA

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CheMyong Ko Division of Clinical and Reproductive Sciences, Department of Anatomy and Neurobiology, Animal Sciences, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, INSERM, ULP, College de France) and Institut Clinique de la Souris, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
Division of Clinical and Reproductive Sciences, Department of Anatomy and Neurobiology, Animal Sciences, Institut de Genetique et de Biologie Moleculaire et Cellulaire (CNRS, INSERM, ULP, College de France) and Institut Clinique de la Souris, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA

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, Christian et al . 2005 ); however, the process by which estrogen controls these events has not been fully understood. Estrogen plays its role by modulating the activity of α and/or β subtypes of estrogen receptors (ERs) in a tissue type-dependent manner

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0358
Volume/Issue:
Volume 195: Issue 3
Free access
Marcello Maggiolini
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Didier Picard Department of Pharmaco-Biology, Département de Biologie Cellulaire, University of Calabria, 87030 Rende, Italy

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Discovery and history of GPR30 In contrast to what some text books might have advocated, for a lot of hormones and receptors, there is no one-to-one relationship. The steroid hormone estrogen, represented by the most potent physiological estrogen 17

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0242
Volume/Issue:
Volume 204: Issue 2
Free access
Koen D Flach Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Wilbert Zwart Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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this disease every year ( Ferlay et al. 2015 ). Approximately 70% of breast tumors are estrogen receptor α (ERα) positive, and tumor cell proliferation is thought to be dependent on the activity of this hormone-mediated transcription factor ( Hayashi

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0003
Volume/Issue:
Volume 229: Issue 2
Free access
Ekaterine Tskitishvili Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Christel Pequeux Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Carine Munaut Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Renaud Viellevoye Department of Pediatrics, Neonatal Intensive Care Unit, University of Liege, CHR de la CITADELLE, Liege, Belgium

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Michelle Nisolle Department of Obstetrics and Gynecology, University of Liege, CHR de la CITADELLE, Liege, Belgium

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Agnes Noël Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Jean-Michel Foidart Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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( Shankaran et al . 2005 ). So far, no medical treatment provides important neuroprotection against neonatal HIE. E4 is a natural human fetal estrogen with selective estrogen receptor modulator activity (SERM) ( Abot et al . 2014 ). Its synthesis amounts

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0434
Volume/Issue:
Volume 232: Issue 1
Open access
Liyuan Tian Molecular Biology, Endocrinology, Departments of

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Zhiqiang Wu Molecular Biology, Endocrinology, Departments of

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Yali Zhao Molecular Biology, Endocrinology, Departments of

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Yuanguang Meng Molecular Biology, Endocrinology, Departments of

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Yiling Si Molecular Biology, Endocrinology, Departments of

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Xiaobing Fu Molecular Biology, Endocrinology, Departments of

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Yiming Mu Molecular Biology, Endocrinology, Departments of

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Weidong Han Molecular Biology, Endocrinology, Departments of

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). The biological effects of estrogens are mediated by two forms of estrogen receptor, ERα and ERβ. Classically, ERα is activated by estrogen binding, which leads to receptor phosphorylation, dimerization, and recruitment of coactivators to the estrogen

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0054
Volume/Issue:
Volume 202: Issue 1
Free access