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Richard Truse Department of Anesthesiology, Duesseldorf University Hospital, Duesseldorf, Germany

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Fabian Voß Department of Anesthesiology, Duesseldorf University Hospital, Duesseldorf, Germany

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Anna Herminghaus Department of Anesthesiology, Duesseldorf University Hospital, Duesseldorf, Germany

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Jan Schulz Department of Anesthesiology, Duesseldorf University Hospital, Duesseldorf, Germany

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Andreas P M Weber Institute of Plant Biochemistry, Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

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Tabea Mettler-Altmann Institute of Plant Biochemistry, Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

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Inge Bauer Department of Anesthesiology, Duesseldorf University Hospital, Duesseldorf, Germany

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Olaf Picker Department of Anesthesiology, Duesseldorf University Hospital, Duesseldorf, Germany

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Christian Vollmer Department of Anesthesiology, Duesseldorf University Hospital, Duesseldorf, Germany

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), which by itself might negatively affect gastrointestinal perfusion and oxygenation. To avoid systemic adverse side effects, topical drug application was established in a variety of different organs, like inhaled prostacyclin in pulmonary hypertension

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0030
Volume/Issue:
Volume 241: Issue 3
Free access
Christian Vollmer Department of Anesthesiology, University Hospital Duesseldorf, Moorenstraße 5, 40225 Duesseldorf, Germany

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Ingo Schwartges Department of Anesthesiology, University Hospital Duesseldorf, Moorenstraße 5, 40225 Duesseldorf, Germany

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Robert Behmke Department of Anesthesiology, University Hospital Duesseldorf, Moorenstraße 5, 40225 Duesseldorf, Germany

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Inge Bauer Department of Anesthesiology, University Hospital Duesseldorf, Moorenstraße 5, 40225 Duesseldorf, Germany

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Olaf Picker Department of Anesthesiology, University Hospital Duesseldorf, Moorenstraße 5, 40225 Duesseldorf, Germany

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and heart failure. Thus, it is not only important to know about the effects of HC and the RAAS on gastrointestinal mucosal oxygenation, but also essential to know about the interaction and possible counteracting effects of both therapies with special

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0132
Volume/Issue:
Volume 218: Issue 3
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Christian Vollmer Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany

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Ingo Schwartges Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany

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Silke Naber Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany

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Christopher Beck Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany

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Inge Bauer Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany

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Olaf Picker Department of Anesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany

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particular oxygenation of the gastrointestinal mucosa are considered crucial for the prevention and therapy of critical illness ( Trzeciak et al . 2008 ). Thus, growing effort is made to develop strategies to improve splanchnic mucosal oxygenation. In this

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0526
Volume/Issue:
Volume 217: Issue 1
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Antonella Amato
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Sara Baldassano
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Rosa Liotta Laboratorio di Fisiologia Generale, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy

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Rosa Serio
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Flavia Mulè
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Introduction Glucagon-like peptide 1 (GLP1), produced by intestinal enteroendocrine L-cells in response to the ingestion of nutrients ( Schirra et al . 1996 ), is highly insulinotropic and an inhibitor of gastrointestinal motility, effects that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0525
Volume/Issue:
Volume 221: Issue 1
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Rijin Xiao
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Leah J Hennings
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Thomas M Badger
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Frank A Simmen
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Introduction Diet is an important factor in the prevention as well as etiology of human cancers, including those of the gastrointestinal tract ( Aggarwal &Shishodia 2006 ). Soy foods andsoy constituents have received considerable

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0256
Volume/Issue:
Volume 195: Issue 1
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Ann T Hanna-Mitchell Departments of Medicine-Renal Electrolyte Division, Pharmacology and Chemical Biology, Department of Veterinary Clinical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Amanda Wolf-Johnston Departments of Medicine-Renal Electrolyte Division, Pharmacology and Chemical Biology, Department of Veterinary Clinical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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James R Roppolo Departments of Medicine-Renal Electrolyte Division, Pharmacology and Chemical Biology, Department of Veterinary Clinical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Tony C A Buffington Departments of Medicine-Renal Electrolyte Division, Pharmacology and Chemical Biology, Department of Veterinary Clinical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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Lori A Birder Departments of Medicine-Renal Electrolyte Division, Pharmacology and Chemical Biology, Department of Veterinary Clinical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Departments of Medicine-Renal Electrolyte Division, Pharmacology and Chemical Biology, Department of Veterinary Clinical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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peripheral tissues, including the skin, gastrointestinal tract (GIT), pancreas, and adrenal glands, where they are proposed to play a role in tissue homeostasis ( Slominski et al . 2001 , Li et al . 2007 , Tsatsanis et al . 2007 , Larauche et al . 2009

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0422
Volume/Issue:
Volume 222: Issue 1
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Fabio Arturo Iannotti Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Campania, Italy

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Vincenzo Di Marzo Director, Joint International Research Unit for the Chemical and Biomolecular Study of the Microbiome in Metabolic Health and Nutrition (JIRU-MicroMeNu) between the Consiglio Nazionale delle Ricerche (CNR, Institute of Biomolecular Chemistry) and Université Laval, Naples, Campania, Italy
Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Department of Medicine, Faculty of Medicine and School of Nutrition, Faculty of Agricultural and Food Sciences, CRIUCPQ, INAF and Centre NUTRISS, Université Laval, Québec City, Canada

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microbiota, encompassing bacteria, archeobacteria, viruses and fungi living in the mammalian gastrointestinal system, plays a fundamental role in the control of the host energy metabolism ( Evans et al. 2013 , Cani 2019 , Koh & Bäckhed 2020 ). Such

Article Type:
Review Article
Collections:
Gut microbiome special collection
DOI:
https://doi.org/10.1530/JOE-20-0444
Volume/Issue:
Volume 248: Issue 2
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Neerav Mullur The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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Arianne Morissette The University of Ottawa Heart Institute, Ottawa, Ontario, Canada

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Nadya M Morrow The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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Erin E Mulvihill The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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Introduction The incretin concept stems from the observation that insulin levels are higher following the intake of glucose through the gastrointestinal tract compared to an isoglycemic exposure to the islet through intravenous glucose

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-24-0046
Volume/Issue:
Volume 263: Issue 1
Open access
Steffen Søndergaard Madsen Institute of Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695-7617, USA

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Lars Nørholm Jensen Institute of Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695-7617, USA

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Christian Kølbæk Tipsmark Institute of Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695-7617, USA

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Pia Kiilerich Institute of Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695-7617, USA

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Russell John Borski Institute of Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695-7617, USA

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. After excision of the gill arches, the cartilage arch was trimmed away and the row of gill filaments was cut into blocks of approximately 2–4 pairs of filaments. The blocks from one fish were pooled in a Petri dish containing oxygenated (99% O 2 /1% CO 2

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0016
Volume/Issue:
Volume 192: Issue 1
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Keerati Wanchai Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
School of Medicine, Mae Fah Luang University, Chiang Rai, Thailand

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Sakawdaurn Yasom Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Wannipa Tunapong Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Titikorn Chunchai Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Parameth Thiennimitr Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Chaiyavat Chaiyasut Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand

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Anchalee Pongchaidecha Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Varanuj Chatsudthipong Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand

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Siriporn Chattipakorn Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand

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Nipon Chattipakorn Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Anusorn Lungkaphin Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Center for Research and Development of Natural Products for Health, Chiang Mai University, Chiang Mai, Thailand

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estimated using the renal cortical slice uptake method. The kidney was decapsulated and placed into freshly oxygenated ice-cold modified Cross and Taggart saline buffer (this contains: 95 mM NaCl, 80 mM mannitol, 5 mM KCl, 0.74 mM CaCl 2 , and 9.5 mM Na 2

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0471
Volume/Issue:
Volume 237: Issue 1
Free access