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Cristina Aresté, M Jesús Melià, Joan Isern, José Luis Tovar, and Anna Meseguer

growth, homeostasis, differentiation and development. The molecular nature of tissue-specific gene regulation by androgens has not been well defined, partly as a result of the variable expression and incomplete regulation of currently available gene

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N Berteaux, S Lottin, E Adriaenssens, F Van Coppenolle, X Leroy, J Coll, T Dugimont, and J-J Curgy

). Later, our group performed in vivo and in vitro experiments that demonstrated that the H19 gene expression was regulated by steroid hormones in both mammary gland and uterus with an up- and down-regulation attributed respectively to 17-β

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Petra Popovics, Zoltan Rekasi, Alan J Stewart, and Magdolna Kovacs

vehicle- and hormone-treated cells (*** P <0.001; ** P <0.01; and * P <0.05). The effect of LH and FSH on inhibin/activin subunits and follistatin gene expression To investigate whether the gonadotropins LH and FSH have a role in the regulation of the

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Patricia D Maningat, Partha Sen, Agneta L Sunehag, Darryl L Hadsell, and Morey W Haymond

Introduction The establishment and maintenance of lactation require the concerted regulation by hormones, genes, and local factors. However, little is known about the molecular regulation of milk production in humans due to limitations in obtaining

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Seiji Tsutsumi, Xi Zhang, Keiko Takata, Kazuhiro Takahashi, Richard H Karas, Hirohisa Kurachi, and Michael E Mendelsohn

specific DNA target sequences ( Kannel et al . 1976 , Marcus et al . 1994 , Gardin et al . 1995 , Mendelsohn & Karas 1999 ). Regulation of specific genes in VSMC by estrogen is still not well understood. Recent studies have suggested that nitric oxide

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Jean-Charles Gabillard, Barzan Bahrami Kamangar, and Nuria Montserrat

approach allows us to identify the coordinated regulation between the GH/IGF system genes, which leads to a progressive restoration of this endocrine system. In order to produce a strong disruption of the GH/IGF system, we starved rainbow trout for

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C Giuliani, M Saji, I Bucci, G Fiore, M Liberatore, D S Singer, F Monaco, L D Kohn, and G Napolitano

regulation and identified the transcription factors and the cis -elements on the 5′-flanking regions of the class I gene involved ( Saji et al. 1992 a , 1992 b , 1997 , Giuliani et al. 1995 , Taniguchi et al. 1998 , Giuliani et al. 2000

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J. R. E. Davis

Production of prolactin is very tissue-specific – the gene is present in all cells, but in the rat it is expressed only in the anterior pituitary gland, while in man it is also expressed at low levels in the decidualized endometrium. Much of the work on rat prolactin gene expression has been greatly facilitated by the availability of the rat pituitary tumour-derived GH cell line (including the GH1, GH3 and GH4 cell subclones) which produces both prolactin and growth hormone. In contrast, much less is so far known about the regulation of the human prolactin gene, due in part to the lack of readily available human pituitary tissue for in-vitro studies.

An increasing amount is known about hormonal and intracellular regulation of prolactin mRNA production, which has been reviewed elsewhere (Davis, Belayew & Sheppard, 1989). However, some of the most impressive and important recent advances have been

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Regina Nostramo, Andrej Tillinger, Juan M Saavedra, Ashok Kumar, Varunkumar Pandey, Lidia Serova, Richard Kvetnansky, and Esther L Sabban

for 8 h led to a dose-dependent decrease in Th ( F =4.01; P <0.05) and Dbh ( F =14.28; P <0.001) mRNA levels ( Fig. 3 B). Figure 3 AT 1 and AT 2 receptor-mediated regulation of Th and Dbh gene expression in PC12 cells. (A) PC12 cells were

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Xigui Huang, Baowei Jiao, Chun Kit Fung, Yong Zhang, Walter K K Ho, Chi Bun Chan, Haoran Lin, Deshou Wang, and Christopher H K Cheng

signal transduction mechanisms of the two PRLRs, as well as their in vivo regulation of gene expression by steroid hormones. We have also cloned the promoters of these two genes in black seabream and studied their responsiveness to steroid hormone