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Introduction The current worldwide obesity epidemic drives an increased incidence and prevalence of gestational diabetes mellitus (GDM) as well as type 2 diabetes (T2D) in pregnancy ( Sun et al. 2022 ). In 2019, according to the
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Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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3rd Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
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Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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2nd Internal Department, 3rd Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic
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Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
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Introduction Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy. It is defined as diabetes diagnosed in the second or third trimester of pregnancy in patients with no history of diabetes prior to gestation
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Physiology and Pharmacology, Western University, London, Ontario, Canada
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of developing complications associated with diabetes. On the other hand, gestational diabetes mellitus (GDM) is another form of diabetes that is characterized by hyperglycemia that first appears during pregnancy. This form of diabetes occurs when
Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia
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Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia
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Mercy Perinatal Research Centre, University of Queensland Centre for Clinical Research, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, Heidelberg, Victoria, Australia
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). Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with onset or first recognition during pregnancy ( Kuhl 1998 ), affects up to 18% of all pregnancies ( Pregnancy 2010 ). Like type 2 diabetes, the prevalence rate of GDM has also
Obstetrics, Mercy Perinatal Research Centre, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Level 4/163 Studley Road, Heidelberg, Victoria 3084, Australia
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Introduction Gestational diabetes mellitus (GDM) is characterised as any degree of glucose intolerance with first recognition during pregnancy. It is the most common type of diabetes found in pregnancy, affecting up to 14% of all pregnancies ( Kim
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Introduction The in utero environment plays an important role in the development of the fetus and the neonate ( Harris et al. 2017 , Marciniak et al. 2017 ). Pre-gestational diabetes affects organogenesis and increases the risk of
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environment ( Masuzaki et al. 1997 , Lea et al. 2000 , Lepercq et al. 2001 , Akerman et al. 2002 , Lindsay et al. 2003 , Yura et al. 2003 ); however their expression and regulation in gestational tissues and in relation to gestational diabetes
Mercy Perinatal Research Centre, Translational Proteomics, Department of Obstetrics and Gynaecology
Mercy Perinatal Research Centre, Translational Proteomics, Department of Obstetrics and Gynaecology
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Mercy Perinatal Research Centre, Translational Proteomics, Department of Obstetrics and Gynaecology
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Mercy Perinatal Research Centre, Translational Proteomics, Department of Obstetrics and Gynaecology
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Introduction Gestational diabetes mellitus (GDM) is a glucose intolerance of varying severity with onset or first recognition during pregnancy that complicates ∼2–4% of pregnancies ( Beischer et al . 1996 ). Both patients with GDM, and their
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Abstract
A number of dramatic changes have been documented in the insulin-like growth factors (IGFs-I and -II) and their binding proteins (IGFBPs) during pregnancy. In this study we have tested the hypothesis that a failure of the normal proteolytic modification of IGFBP-3 is responsible for gestational diabetes by examining serum samples taken in the third trimester from 29 women with uncomplicated pregnancies, 21 women with established Type 1 diabetes and 20 women with gestational diabetes. Analysis of IGFBP-3 by Western immunoblotting revealed that it was present in a modified form, migrating at around 29 kDa, in the circulation of all of the women investigated. Semiquantification of the activity of the protease which modifies the IGFBP-3 demonstrated considerable variation between individuals in their ability to fragment radiolabelled IGFBP-3 following a 45-min co-incubation. Surprisingly, in one individual (with gestational diabetes) there was no detectable protease activity even though her endogenous IGFBP-3 had been modified. However, overall there was no clear-cut difference in protease activity between the different groups.
Radioimmunometric analysis of IGF-I revealed significantly higher levels in women with gestational diabetes than either of the other two groups (P<0·05). Similarly IGFBP-3 levels were also increased in these same women (P<0·05). In contrast, IGF-II levels did not alter between the three groups.
In conclusion, our hypothesis was not supported by these data and gestational diabetes was found not to be associated with any reduction in the activity of the circulating IGFBP-3 protease which could have decreased the availability of the IGF nor with any alteration in IGFs which could explain the onset of diabetes in these women.
Journal of Endocrinology (1995) 147, 517–524
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. Gestational diabetes: dogs A fourth category in the human classification model is gestational diabetes, which is defined as carbohydrate intolerance with onset or first recognition during pregnancy ( ADA 2013 ). A syndrome resembling gestational diabetes in
