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Motoyasu Satou
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Yoshihiro Nishi Department of Biochemistry, Department of Physiology, Department of Infection Control and Clinical Laboratory Medicine, Department of Biochemistry, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan

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Akira Hishinuma Department of Biochemistry, Department of Physiology, Department of Infection Control and Clinical Laboratory Medicine, Department of Biochemistry, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan

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Hiroshi Hosoda Department of Biochemistry, Department of Physiology, Department of Infection Control and Clinical Laboratory Medicine, Department of Biochemistry, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan

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Kenji Kangawa Department of Biochemistry, Department of Physiology, Department of Infection Control and Clinical Laboratory Medicine, Department of Biochemistry, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan

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Hiroyuki Sugimoto
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Introduction Ghrelin was first identified by Kojima et al . (1999) as an endogenous ligand for the growth hormone secretagogue receptor type 1a (GHSR1a, Howard et al . 1996 ) present in the rat stomach. This hormone is a 28-amino acid peptide

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0529
Volume/Issue:
Volume 224: Issue 1
Free access
T Takahashi Laboratory of Animal Physiology, Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amemiyamachi, Aoba-ku, Sendai 981-8555, Japan

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K Sato Laboratory of Animal Physiology, Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amemiyamachi, Aoba-ku, Sendai 981-8555, Japan

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S Kato Laboratory of Animal Physiology, Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amemiyamachi, Aoba-ku, Sendai 981-8555, Japan

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T Yonezawa Laboratory of Animal Physiology, Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amemiyamachi, Aoba-ku, Sendai 981-8555, Japan

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Y Kobayashi Laboratory of Animal Physiology, Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amemiyamachi, Aoba-ku, Sendai 981-8555, Japan

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Y Ohtani Laboratory of Animal Physiology, Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amemiyamachi, Aoba-ku, Sendai 981-8555, Japan

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S Ohwada Laboratory of Animal Physiology, Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amemiyamachi, Aoba-ku, Sendai 981-8555, Japan

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H Aso Laboratory of Animal Physiology, Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amemiyamachi, Aoba-ku, Sendai 981-8555, Japan

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T Yamaguchi Laboratory of Animal Physiology, Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amemiyamachi, Aoba-ku, Sendai 981-8555, Japan

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S G Roh Laboratory of Animal Physiology, Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amemiyamachi, Aoba-ku, Sendai 981-8555, Japan

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K Katoh Laboratory of Animal Physiology, Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amemiyamachi, Aoba-ku, Sendai 981-8555, Japan

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Introduction Ghrelin, an endogenous ligand for growth hormone secretagogue receptor (GHSR), is produced primarily by the stomach ( Kojima et al . 1999 , Ariyasu et al . 2001 ) as well as the intestine, and then released into circulation. Ghrelin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0501
Volume/Issue:
Volume 221: Issue 3
Free access
Anneleen Segers Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium

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Louis Desmet Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium

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Shu Sun Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium

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Kristin Verbeke Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium

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Jan Tack Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium

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Inge Depoortere Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium

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Introduction Ghrelin, a 28-amino acid peptide, is the only known circulating hormone that stimulates food intake ( Kojima et al . 1999 ). Ghrelin is mainly produced in the stomach and is acylated by ghrelin O-acyltransferase (GOAT) on Ser 3

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0011
Volume/Issue:
Volume 245: Issue 1
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Sabina Börner
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Michael Derno
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Sandra Hacke
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Ulrike Kautzsch
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Christine Schäff
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Sint ThanThan Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Hideto Kuwayama Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Harald M Hammon
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Monika Röntgen
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Rosemarie Weikard Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Christa Kühn Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Armin Tuchscherer Research Unit Nutritional Physiology ‘Oskar Kellner’, Agriculture and Veterinary Medicine Inada-cho, Unit Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

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Björn Kuhla
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Introduction Ghrelin is a 28 amino acid peptide in monogastric species and a 27 amino acid peptide in ruminants ( Dickin et al . 2004 ). It is primarily produced by oxyntic cells in the stomach or abomasum respectively with smaller amounts produced

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0384
Volume/Issue:
Volume 216: Issue 2
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Hyunju Chung Department of Core Research Laboratory, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Seoul, Korea

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Seungjoon Park Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea

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Introduction Ghrelin is a unique 28-amino acid peptide hormone mainly produced in the stomach. The peptide is known to act through the activation of the growth hormone (GH) secretagogue receptor 1a ( Kojima et al. 1999 ). Earlier studies

Article Type:
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https://doi.org/10.1530/JOE-16-0126
Volume/Issue:
Volume 230: Issue 2
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Hyunju Chung
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Endan Li Department of Core Research Laboratory, Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Seoul, Korea

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Yumi Kim Department of Core Research Laboratory, Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Seoul, Korea

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Sehee Kim Department of Core Research Laboratory, Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Seoul, Korea

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Seungjoon Park Department of Core Research Laboratory, Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Seoul, Korea

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Introduction Ghrelin, a 28-amino acid peptide hormone mainly produced in the stomach, has been shown to stimulate GH release by activating the GH secretagogue (GHS) receptor 1a (GHS-R1a; Kojima et al . 1999 ). Initial studies have shown that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0045
Volume/Issue:
Volume 218: Issue 1
Free access
Farhana Naznin Division of Neurology, Department of Sports and Fitness, AMED-CREST, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan

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Koji Toshinai Division of Neurology, Department of Sports and Fitness, AMED-CREST, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
Division of Neurology, Department of Sports and Fitness, AMED-CREST, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan

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T M Zaved Waise Division of Neurology, Department of Sports and Fitness, AMED-CREST, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan

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Cherl NamKoong Division of Neurology, Department of Sports and Fitness, AMED-CREST, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan

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Abu Saleh Md Moin Division of Neurology, Department of Sports and Fitness, AMED-CREST, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan

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Hideyuki Sakoda Division of Neurology, Department of Sports and Fitness, AMED-CREST, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan

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Masamitsu Nakazato Division of Neurology, Department of Sports and Fitness, AMED-CREST, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
Division of Neurology, Department of Sports and Fitness, AMED-CREST, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan

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, which are more optimally positioned to monitor bioactive substances released from gastrointestinal enteroendocrine cells. Nodose ganglion neurons are pseudounipolar neurons with two axons running towards the visceral organs and the NTS. Ghrelin, a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0139
Volume/Issue:
Volume 226: Issue 1
Open access
Hiroharu Mifune Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan

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Yuji Tajiri Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan

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Yusuke Sakai Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan

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Yukie Kawahara Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan

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Kento Hara Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan

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Takahiro Sato Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan

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Yoshihiro Nishi Department of Physiology, Kurume University School of Medicine, Kurume, Japan

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Akinori Nishi Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan

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Ryouichi Mitsuzono Department of Exercise Physiology, Institute of Health and Sports Science, Kurume University, Kurume, Japan

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Tatsuyuki Kakuma Bostatistics Center, Kurume University, Kurume, Japan

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Masayasu Kojima Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan

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producing the motivation to perform and adhere to exercise, especially in obese subjects. Ghrelin, which was originally identified as a growth hormone secretagogue (GHS), is an orexigenic gut hormone. This 28-amino acid peptide is produced by the X

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0213
Volume/Issue:
Volume 244: Issue 1
Open access
Harleen Kaur Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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Beverly S Muhlhausler Food and Nutrition Research Group, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia
Nutrition and Health Program, Health and Biosecurity Business Unit, Commonwealth Scientific and Industrial Research Organisation, Adelaide, Australia

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Pamela Su-Lin Sim Food and Nutrition Research Group, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia

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Amanda J Page Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Hui Li Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Maria Nunez-Salces Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Georgia S Clarke Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Lili Huang School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Rebecca L Wilson Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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Johannes D Veldhuis Endocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota, USA

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Chen Chen School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Claire T Roberts Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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Kathryn L Gatford Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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responsible, either indirectly or directly, for driving the increased pituitary GH secretion during rodent pregnancy. Ghrelin, a gastric peptide hormone that acts in conjunction with hypothalamic growth hormone-releasing hormone (GHRH) and somatostatin to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0072
Volume/Issue:
Volume 245: Issue 2
Restricted access
Tetsuya Kouno Discovery Research Laboratory for Innovative Frontier Medicines, Discovery Research Laboratory for Core Therapeutic Areas, Department of Biological Chemistry, Shionogi and Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan
Discovery Research Laboratory for Innovative Frontier Medicines, Discovery Research Laboratory for Core Therapeutic Areas, Department of Biological Chemistry, Shionogi and Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

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Nobuteru Akiyama Discovery Research Laboratory for Innovative Frontier Medicines, Discovery Research Laboratory for Core Therapeutic Areas, Department of Biological Chemistry, Shionogi and Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

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Takahito Ito Discovery Research Laboratory for Innovative Frontier Medicines, Discovery Research Laboratory for Core Therapeutic Areas, Department of Biological Chemistry, Shionogi and Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

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Tomohiko Okuda Discovery Research Laboratory for Innovative Frontier Medicines, Discovery Research Laboratory for Core Therapeutic Areas, Department of Biological Chemistry, Shionogi and Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

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Isamu Nanchi Discovery Research Laboratory for Innovative Frontier Medicines, Discovery Research Laboratory for Core Therapeutic Areas, Department of Biological Chemistry, Shionogi and Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

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Mitsuru Notoya Discovery Research Laboratory for Innovative Frontier Medicines, Discovery Research Laboratory for Core Therapeutic Areas, Department of Biological Chemistry, Shionogi and Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

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Shogo Oka Discovery Research Laboratory for Innovative Frontier Medicines, Discovery Research Laboratory for Core Therapeutic Areas, Department of Biological Chemistry, Shionogi and Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

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Hideo Yukioka Discovery Research Laboratory for Innovative Frontier Medicines, Discovery Research Laboratory for Core Therapeutic Areas, Department of Biological Chemistry, Shionogi and Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

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Introduction Ghrelin, a 28-amino-acid peptide hormone mainly produced by X/A-like cells of the stomach ( Date et al . 2000 ), was originally identified as an endogenous ligand of the growth hormone secretagogue receptor type 1a (GHS-R1a) ( Kojima

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0330
Volume/Issue:
Volume 228: Issue 2
Free access