Search Results

You are looking at 1 - 10 of 814 items for :

  • glucocorticoid receptor x
Clear All
Free access

Ellen H Stolte, B M Lidy Verburg van Kemenade, Huub F J Savelkoul and Gert Flik

Introduction Glucocorticoids (GCs; cortisol and corticosterone) play a pivotal role in vertebrate physiology through a plethora of control mechanisms. The GC system, with a nuclear glucocorticoid receptor (GR), is found in all

Free access

Kerryn M Taylor, David W Ray and Paula Sommer

receptor Glucocorticoids (Gcs) are a class of steroid hormones that function to maintain homeostasis. The effects of Gcs are mediated by the ubiquitously expressed glucocorticoid receptor (GR), an intracellular ligand-activated transcription factor and

Free access

Dieuwertje C E Spaanderman, Mark Nixon, Jacobus C Buurstede, Hetty H C M Sips, Maaike Schilperoort, Eline N Kuipers, Emma A Backer, Sander Kooijman, Patrick C N Rensen, Natalie Z M Homer, Brian R Walker, Onno C Meijer and Jan Kroon

). Glucocorticoid action in metabolism is predominantly mediated by glucocorticoid receptors (GRs) which are expressed in virtually all tissues in both humans and rodents. It is known that glucocorticoid transcriptional activity is subject to multiple levels of

Free access

Alistair I Freeman, Helen L Munn, Val Lyons, Alexander Dammermann, Jonathan R Seckl and Karen E Chapman

Introduction Glucocorticoids exert effects on virtually all tissues, the majority of which are mediated by the type II glucocorticoid receptor (GR). Despite near ubiquitous expression, GR levels vary widely both between and within

Free access

George Schlossmacher, Adam Stevens and Anne White

nucleus, the GR can then act as either a transcriptional activator or a repressor depending on the gene and the cellular environment. Figure 1 Glucocorticoid receptor signalling. The glucocorticoid receptor translocates to the nucleus upon ligand binding

Free access

Ronald J van der Sluis, Miranda Van Eck and Menno Hoekstra

response needed to cope with stress through activation of the glucocorticoid receptor (GR) in target tissues ( Kadmiel & Cidlowski 2013 ). We have previously shown that lipoprotein-associated cholesterol contributes at least 50% to the total cellular pool

Free access

James S M Cuffe, Zarqa Saif, Anthony V Perkins, Karen M Moritz and Vicki L Clifton

glucocorticoid signaling through intricate interactions with steroid receptors is vital for healthy development. While natural glucocorticoids (cortisol and corticosterone) can bind to both the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) to

Restricted access

Erin Faught and Mathilakath M Vijayan

GCs on growth is mediated by the glucocorticoid receptor (GR) activation of proteolytic pathways ( Shimizu et al. 2011 , Lipina & Hundal 2016 , Britto et al. 2018 ). Indeed, both murf1 and redd1 are under the transcriptional control of GR in

Open access

Rachel V Richardson, Emma J Batchen, Adrian J W Thomson, Rowan Darroch, Xinlu Pan, Eva A Rog-Zielinska, Wiktoria Wyrzykowska, Kathleen Scullion, Emad A S Al-Dujaili, Mary E Diaz, Carmel M Moran, Christopher J Kenyon, Gillian A Gray and Karen E Chapman

actions through the closely related glucocorticoid receptor (GR) and mineralocorticoid receptor (MR). Cardiomyocytes lack the glucocorticoid-inactivating enzyme, 11β-hydroxysteroid dehydrogenase type 2 ( Chapman et al . 2013 ). Thus, the effects of

Free access

Helen Garside, Charlotte Waters, Andy Berry, Lisa Rice, Helen C Ardley, Anne White, Philip A Robinson and David Ray

Introduction The glucocorticoid receptor (GR) is a member of the nuclear receptor superfamily. It is a key regulator of many homeostatic mechanisms and is also the target of therapeutic glucocorticoids used to treat inflammatory