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Olivier Dumortier, Gaia Fabris, Didier F Pisani, Virginie Casamento, Nadine Gautier, Charlotte Hinault, Patricia Lebrun, Christophe Duranton, Michel Tauc, Stéphane Dalle, Julie Kerr-Conte, François Pattou, Marc Prentki and Emmanuel Van Obberghen

(disallowed genes) ( Quintens et al . 2008 , Pullen & Rutter 2013 ). Indeed, beta cells have a dedicated metabolism comprising a tightly regulated chain of elements from glucose sensors to a specialized exocytosis machinery. Glucose metabolism in beta cells

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Lars P Klieverik, Ewout Foppen, Mariëtte T Ackermans, Mireille J Serlie, Hans P Sauerwein, Thomas S Scanlan, David K Grandy, Eric Fliers and Andries Kalsbeek

hypothalamus, regulates most of the processes affected by thyronamines (body temperature, cardiac function, and energy metabolism). Moreover, a principal role in regulating hepatic glucose metabolism has recently emerged for the hypothalamus ( Obici et al

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Haijiang Wu, Xinna Deng, Yonghong Shi, Ye Su, Jinying Wei and Huijun Duan

therapy. In this review, we summarize the major findings on the function of PGC-1α in glucose metabolism and discuss its potential therapeutic applications for T2DM. The close correlation between PGC-1α polymorphisms and T2DM is also discussed in this

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Sojin Lee and H Henry Dong

inhibition of glucose production in the liver ( Perry et al. 2015 ). Thus, insulin modulates hepatic gluconeogenesis via both direct and indirect mechanisms ( Ader & Bergman 1990 , Cherrington 2005 ). FoxO6 in hepatic glucose metabolism Although

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Mathis Grossmann

70 years of clinical experience. On the other hand, in functional androgen deficiency due to axis suppression because of age-related comorbidities, treatment may aim for a specific health outcome, such as improvement of glucose metabolism, and

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Paula J Brunton, Katie M Sullivan, David Kerrigan, John A Russell, Jonathan R Seckl and Amanda J Drake

the type of stress pregnant women may experience) with the aim of establishing whether PNS leads to alterations in glucose tolerance, insulin resistance and the expression of genes known to be important in regulating glucose and lipid metabolism and

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Kanta Kon, Hiroshi Tsuneki, Hisakatsu Ito, Yoshinori Takemura, Kiyofumi Sato, Mitsuaki Yamazaki, Yoko Ishii, Masakiyo Sasahara, Assaf Rudich, Takahiro Maeda, Tsutomu Wada and Toshiyasu Sasaoka

and behavioral circadian misalignments in modern lifestyle, such as shift work and late eating, lead to dysregulation of glucose metabolism and increased risk of type 2 diabetes ( Cedernaes et al. 2015 , Qian et al. 2016 ). Intriguingly, one night

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K L Franko, A J Forhead and A L Fowden

, little is known about the effects of commonly used control procedures, such as maternal saline or vehicle injection, on glucose metabolism of their offspring. The current study, therefore, compared the effects of maternal injection with dex or saline with

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B Maiztegui, M I Borelli, M A Raschia, H Del Zotto and J J Gagliardino

. 2003 ). Evidence in the literature has shown that glucokinase (GK) activity plays a pivotal role upon islet glucose metabolism and insulin secretion. As opposed to other hexokinases (HK), GK kinetics shows a cooperative glucose dependence (Hill

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Firoozeh Salehzadeh, Anna Rune, Megan Osler and Lubna Al-Khalili

17β-estradiol (E 2 ) has no effect. Thus, testosterone and E 2 have differential effects on glucose metabolism in skeletal muscle ( Ramamani et al . 1999 ). In addition to the role of sex hormones in glucose metabolism, these mediators also play a