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John A H Wass and Raghava Reddy

Introduction Much has been written about the effects of growth hormone (GH) replacement therapy in GH-deficient human subjects on growth, body composition, cardiovascular risk factors, bone and muscle development and quality of life. When properly

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Rajat K Das, Sarmistha Banerjee and Bernard H Shapiro

differences in CYP expression occurs postpubertally) ( Shapiro et al . 1995 ). The only endogenous factor known to regulate the expression of adult hepatic CYP is growth hormone (GH) ( Legraverend et al . 1992 , Shapiro et al . 1995 ). At puberty, males

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A J Forhead and A L Fowden

& Forhead 2009 , 2013 ). Deficiency of thyroid hormones during intrauterine development impairs growth of the fetus and compromises its adaptation to extrauterine life ( Fowden et al . 1998 , Hillman et al . 2012 , Sferruzzi-Perri et al . 2013

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C. G. D. Brook, P. C. Hindmarsh and R. Stanhope

The Endocrine Unit, Cobbold Laboratories, Middlesex Hospital, London win 8aa *Department of Growth and Development, Institute of Child Health, Guilford Street, London wcin 1eh REVISED MANUSCRIPT RECEIVED 26 April 1988


The human growth curve divides into three distinct time-spans. There is a period of rapid and rapidly decelerating growth during infancy. This changes in the third year to a period of steady and slowly decelerating growth during childhood. Growth is completed by the adolescent growth spurt which, because it occurs later and is slightly greater in magnitude in boys than in girls, accounts for the sex differences in adult height.

Growth in infancy

Clinical observation of patients born with congenital hypopituitarism indicates clearly that growth hormone is important for growth from the day of birth. On the other hand, it seems likely that nutritional influences play the major role in fetal and infantile growth; such

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J Cruickshank, D I Grossman, R K Peng, T R Famula and A M Oberbauer

growth hormone (GH) or steroids. The effects of GH are mediated through the actions of insulin-like growth factor-I (IGF-I), a peptide growth factor produced in great abundance by hepatic tissue (reviewed in Le Roith et al. 2001 ). Growth hormone

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J T Smith, A Roseweir, M Millar, I J Clarke and R P Millar

physiological status to reproduction ( Pineda et al . 2010 a ). Growth hormone (GH) plays a role in normal reproductive function ( Hull & Harvey 2001 , 2002 ) and in metabolic regulation. A substantial number of studies have now reported effects of

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Zhengxiang Huang, Lili Huang, Chengjian Wang, Shanli Zhu, Xinzhou Qi, Yang Chen, Yanjun Zhang, Michael A Cowley, Johannes D Veldhuis and Chen Chen

Introduction Hormonal disturbance, in either secretion amount or function, often occurs in parallel with impairment of glucose/lipid/protein metabolism in obesity. Two pivotal hormones, insulin and growth hormone (GH), which synergistically

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A. L. Ogilvy-Stuart and S. M. Shalet

In a child, puberty encompasses a series of events which include the completion of growth and the maturing of the reproductive system. One of the common hormonal links between these two processes is growth hormone (GH) and, although it has been known for some time that the reproductive axis influences GH secretion and growth, increasing interest is developing in the alternative possibility of GH modifying reproductive processes.

In the normal child, there is an increase in GH secretion from mid-childhood with a shift in periodicity and an increase in pulse amplitude (Hindmarsh, Mathews & Brook, 1988). The two- to threefold rise in GH secretion during puberty is a product of the increase in pulse amplitude over the prepubertal value (Martha, Rogol, Veldhuis et al. 1989; Delemarre-van de Waal, Wennink & Odink, 1991). GH pulse amplitude is increased during early puberty in girls and at a later stage in boys, corresponding

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Maria Alba and Roberto Salvatori

Introduction The production and secretion of growth hormone (GH) from the anterior pituitary is stimulated by the hypothalamic growth hormone releasing hormone (GHRH) and inhibited by somatostatin ( Muller et al. 1999 ). GHRH is

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Rita Sharma, Quyen Luong, Vishva M Sharma, Mitchell Harberson, Brian Harper, Andrew Colborn, Darlene E Berryman, Niels Jessen, Jens Otto Lunde Jørgensen, John J Kopchick, Vishwajeet Puri and Kevin Y Lee

Introduction Although growth hormone (GH) has been primarily studied for its effects on linear growth, pronounced stimulation of lipolysis was among the first metabolic effects reported in human subjects following the introduction of pituitary