Search Results
Search for other papers by Ewa Ocłoń in
Google Scholar
PubMed
Search for other papers by Anna Latacz in
Google Scholar
PubMed
Search for other papers by Joanna Zubel–Łojek in
Google Scholar
PubMed
Search for other papers by Krystyna Pierzchała–Koziec in
Google Scholar
PubMed
Introduction Accumulation of visceral adipose tissue has been associated with an increased risk of metabolic syndrome defined by a combination of insulin resistance, hyperglycemia, dyslipidemia, increased expression of inflammatory mediators
Search for other papers by Xiaojun Zhou in
Google Scholar
PubMed
Search for other papers by Jianjun Dong in
Google Scholar
PubMed
Search for other papers by Li Zhang in
Google Scholar
PubMed
Search for other papers by Ju Liu in
Google Scholar
PubMed
Search for other papers by Xiaofeng Dong in
Google Scholar
PubMed
Search for other papers by Qing Yang in
Google Scholar
PubMed
Search for other papers by Fupeng Liu in
Google Scholar
PubMed
Search for other papers by Lin Liao in
Google Scholar
PubMed
. In the diabetic state, hyperglycemia, which can enhance intimal hyperplasia by induction of platelet hypersensitivity, dyslipidemia, and dysregulation of expression of chemotactic factors ( Barbieri et al . 2013 , Zeadin et al . 2013 ), is
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, China
Search for other papers by Junhong Chen in
Google Scholar
PubMed
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, China
Search for other papers by Jing Sun in
Google Scholar
PubMed
Search for other papers by Michelle E Doscas in
Google Scholar
PubMed
Search for other papers by Jin Ye in
Google Scholar
PubMed
Search for other papers by Ashley J Williamson in
Google Scholar
PubMed
Search for other papers by Yanchun Li in
Google Scholar
PubMed
Search for other papers by Yi Li in
Google Scholar
PubMed
Search for other papers by Richard A Prinz in
Google Scholar
PubMed
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, China
Department of Cell and Molecular Medicine, Rush University Medical Center, Chicago, Illinois, USA
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou, China
Search for other papers by Xiulong Xu in
Google Scholar
PubMed
-term use ( Nathan 2015 ). Failure to control hyperglycemia leads to diabetic complications, which account for most diabetes-related morbidity and mortality ( Nathan 2015 ). Because of physical inactivity and circulating inflammatory cytokines, diabetic
Search for other papers by Qiong You in
Google Scholar
PubMed
Search for other papers by Zijun Wu in
Google Scholar
PubMed
Search for other papers by Bin Wu in
Google Scholar
PubMed
Search for other papers by Chang Liu in
Google Scholar
PubMed
Search for other papers by Ruina Huang in
Google Scholar
PubMed
Search for other papers by Li Yang in
Google Scholar
PubMed
Search for other papers by Runmin Guo in
Google Scholar
PubMed
Search for other papers by Keng Wu in
Google Scholar
PubMed
Search for other papers by Jingfu Chen in
Google Scholar
PubMed
failure ( Lakdawala et al . 2013 , Camafort 2015 ) and sudden death in young people ( Ellis & Di Salvo 2007 ). DCM is different from hypertensive cardiomyopathy and is a unique cardiovascular disease due to hyperglycemia-induced oxidative stress
Search for other papers by Qiongge Zhang in
Google Scholar
PubMed
Search for other papers by Chaoqun Wang in
Google Scholar
PubMed
Search for other papers by Yehua Tang in
Google Scholar
PubMed
Search for other papers by Qiangqiang Zhu in
Google Scholar
PubMed
Search for other papers by Yongcheng Li in
Google Scholar
PubMed
Search for other papers by Haiyan Chen in
Google Scholar
PubMed
Search for other papers by Yi Bao in
Google Scholar
PubMed
Search for other papers by Song Xue in
Google Scholar
PubMed
Search for other papers by Liangliang Sun in
Google Scholar
PubMed
Search for other papers by Wei Tang in
Google Scholar
PubMed
Search for other papers by Xiangfang Chen in
Google Scholar
PubMed
Search for other papers by Yongquan Shi in
Google Scholar
PubMed
Search for other papers by Lefeng Qu in
Google Scholar
PubMed
Search for other papers by Bin Lu in
Google Scholar
PubMed
Search for other papers by Jiaoyang Zheng in
Google Scholar
PubMed
Introduction Hyperglycemia is believed to play a major role in the development of diabetic macrovascular complications, including atherosclerosis and restenosis, which are responsible for the most of disability and mortality observed in
Search for other papers by Kok Lim Kua in
Google Scholar
PubMed
Search for other papers by Shanming Hu in
Google Scholar
PubMed
Search for other papers by Chunlin Wang in
Google Scholar
PubMed
Search for other papers by Jianrong Yao in
Google Scholar
PubMed
Search for other papers by Diana Dang in
Google Scholar
PubMed
Search for other papers by Alexander B Sawatzke in
Google Scholar
PubMed
Search for other papers by Jeffrey L Segar in
Google Scholar
PubMed
Search for other papers by Kai Wang in
Google Scholar
PubMed
Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, USA
Search for other papers by Andrew W Norris in
Google Scholar
PubMed
diabetes have received little experimental attention to date. Diabetes during pregnancy exposes the fetus to multiple perturbations during a critical development period. These perturbations extend beyond hyperglycemia and include maternal ketosis, altered
Search for other papers by Gen Chen in
Google Scholar
PubMed
Search for other papers by Xiangjuan Chen in
Google Scholar
PubMed
Search for other papers by Chao Niu in
Google Scholar
PubMed
Search for other papers by Xiaozhong Huang in
Google Scholar
PubMed
Search for other papers by Ning An in
Google Scholar
PubMed
Search for other papers by Jia Sun in
Google Scholar
PubMed
Search for other papers by Shuai Huang in
Google Scholar
PubMed
Search for other papers by Weijian Ye in
Google Scholar
PubMed
Search for other papers by Santie Li in
Google Scholar
PubMed
Search for other papers by Yingjie Shen in
Google Scholar
PubMed
Search for other papers by Jiaojiao Liang in
Google Scholar
PubMed
Search for other papers by Weitao Cong in
Google Scholar
PubMed
Search for other papers by Litai Jin in
Google Scholar
PubMed
, activation of Nrf2 has been shown to be protective against hyperglycemia-induced apoptosis and cell damage in renal, cardiac and vascular cells ( Li et al. 2012 ). Hence, Nrf2 signaling represents a therapeutic target for cardiovascular complications in
Search for other papers by David A Baltzegar in
Google Scholar
PubMed
Search for other papers by Benjamin J Reading in
Google Scholar
PubMed
Search for other papers by Jonathon D Douros in
Google Scholar
PubMed
Search for other papers by Russell J Borski in
Google Scholar
PubMed
hyperglycemia in fishes ( Mommsen 2000 ). Similarly, cortisol promotes hyperglycemia through gluconeogenesis in fishes and mammals ( Vijayan et al . 1996 , Khani & Tayek 2001 ), but it also promotes sodium excretion through the gill during SW adaptation
Department of Clinical Research, Cardiovascular Research Institute, Institute of Medical Biology, Department of Surgery, Singapore General Hospital, Block A, #03-04, 7 Hospital Drive, SingHealth Research Facility, Singapore, 169611 Singapore
Search for other papers by Shiying Shao in
Google Scholar
PubMed
Search for other papers by Yun Gao in
Google Scholar
PubMed
Department of Clinical Research, Cardiovascular Research Institute, Institute of Medical Biology, Department of Surgery, Singapore General Hospital, Block A, #03-04, 7 Hospital Drive, SingHealth Research Facility, Singapore, 169611 Singapore
Search for other papers by Bing Xie in
Google Scholar
PubMed
Search for other papers by Fei Xie in
Google Scholar
PubMed
Department of Clinical Research, Cardiovascular Research Institute, Institute of Medical Biology, Department of Surgery, Singapore General Hospital, Block A, #03-04, 7 Hospital Drive, SingHealth Research Facility, Singapore, 169611 Singapore
Search for other papers by Sai Kiang Lim in
Google Scholar
PubMed
Department of Clinical Research, Cardiovascular Research Institute, Institute of Medical Biology, Department of Surgery, Singapore General Hospital, Block A, #03-04, 7 Hospital Drive, SingHealth Research Facility, Singapore, 169611 Singapore
Search for other papers by GuoDong Li in
Google Scholar
PubMed
cells. In addition, these cells can be stably expanded to a large number with no loss in insulin content ( Li et al . 2009 b ). In vivo , MEPI-1 cells engraft and reverse streptozotocin (STZ)-induced hyperglycemia in SCID mice without producing
Search for other papers by Prabhakara R Nagareddy in
Google Scholar
PubMed
Search for other papers by Sunil K Noothi in
Google Scholar
PubMed
Department of Immunology, Monash University, Melbourne, Australia
Search for other papers by Michelle C Flynn in
Google Scholar
PubMed
Department of Immunology, Monash University, Melbourne, Australia
Search for other papers by Andrew J Murphy in
Google Scholar
PubMed
) Obesity indirectly promotes myelopoiesis by stimulating IL-1β production from ATM in VAT. (C) Hyperglycemia induces an upregulation in S100A8/A9 that travels to BM to stimulate myelopoiesis. ATM, adipose tissue macrophages; BM, bone marrow; HSPC