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Ivana Vaněčková Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Lenka Maletínská Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Michal Behuliak Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Veronika Nagelová Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Josef Zicha Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Jaroslav Kuneš Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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relationship between obesity and hypertension is widely recognized, there is a question as to what is the primary abnormality? It has been suggested that obesity is characterized by a cascade of metabolic and cardiovascular disorders, including hypertension

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0368
Volume/Issue:
Volume 223: Issue 3
Free access
Ding Xie Department of Family Medicine, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA

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Wendy B Bollag Charlie Norwood VA Medical Center, Augusta, Georgia, USA
Department of Physiology, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA

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It is well known that obesity is associated with a number of metabolic end organ dysfunctions, including hypertension. However, less well understood is the mechanism by which obesity leads to elevated blood pressure. Various hypotheses have

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0160
Volume/Issue:
Volume 230: Issue 1
Free access
P Nguyen Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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S Khurana Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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H Peltsch Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Grandbois Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Eibl Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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J Crispo Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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D Ansell Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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T C Tai Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada

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birth weight and developmental programming of hypertension has been correlated with impaired kidney development and dysregulated renin-angiotensin-aldosterone system ( Baum 2010 , Goyal et al . 2010 ), impaired vascular structure and function ( Pladys

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0244
Volume/Issue:
Volume 227: Issue 2
Free access
T Pasqua
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B Tota
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C Penna Laboratory of Cardiovascular Pathophysiology, Department of Clinical and Biological Sciences, Tumor Biology and Vascular Targeting Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Department of Biology, Ecology, and E.S., University of Calabria, 87036 Arcavacata di Rende (CS), Italy

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A Corti Laboratory of Cardiovascular Pathophysiology, Department of Clinical and Biological Sciences, Tumor Biology and Vascular Targeting Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Department of Biology, Ecology, and E.S., University of Calabria, 87036 Arcavacata di Rende (CS), Italy

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M C Cerra
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Y P Loh Laboratory of Cardiovascular Pathophysiology, Department of Clinical and Biological Sciences, Tumor Biology and Vascular Targeting Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Department of Biology, Ecology, and E.S., University of Calabria, 87036 Arcavacata di Rende (CS), Italy

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T Angelone
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therapeutic scheme may be complicated by comorbidities, such as hypertension. This risk factor determines important alterations in cellular signaling pathways with consequences on the development of I/R damage and the efficacy of cardioprotective interventions

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0199
Volume/Issue:
Volume 227: Issue 3
Free access
Ying-Ying Tsai Department of Physiology, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA

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William E Rainey Departments of Molecular & Integrative Physiology and Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

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Wendy B Bollag Department of Physiology, Medical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA
Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA

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conditions. In addition to its role in helping to regulate blood pressure, accumulating evidence points to the idea that excessive production/secretion of this hormone not only results in hypertension but also likely contributes to cardiac fibrosis and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0237
Volume/Issue:
Volume 232: Issue 2
Free access
Achim Lother Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Lisa Deng Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Michael Huck Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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David Fürst Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Jessica Kowalski Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Jennifer S Esser Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Martin Moser Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Christoph Bode Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Lutz Hein Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany

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& Jaffe 2017 ). A series of studies using cell type-specific MR deletion models revealed distinct roles of MR in these different cell types for hypertension, atherosclerosis, myocardial infarction and heart failure and in particular found MR in endothelial

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0494
Volume/Issue:
Volume 240: Issue 1
Free access
Kelly De Sousa INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France
Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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Alaa B Abdellatif INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France
Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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Rami M El Zein INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France
Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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Maria-Christina Zennaro INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France
Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Génétique, Paris, France

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Introduction Primary aldosteronism (PA) is due to excessive and autonomous aldosterone production by the adrenal cortex. It is the most frequent form of secondary hypertension with an estimated prevalence up to 10% in referred patients, 4% in

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0193
Volume/Issue:
Volume 242: Issue 3
Free access
Ruben Rodriguez Department of Molecular & Cellular Biology, University of California, Merced, California, USA

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Jacqueline N Minas Department of Molecular & Cellular Biology, University of California, Merced, California, USA

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Jose Pablo Vazquez-Medina Department of Integrative Biology, University of California, Berkeley, California, USA

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Daisuke Nakano Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan

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David G Parkes DGP Scientific Inc., Del Mar, California, USA

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Akira Nishiyama Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan

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Rudy M Ortiz Department of Molecular & Cellular Biology, University of California, Merced, California, USA

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, hyperglycemia and hypertension on pancreatic function and peripheral insulin resistance. Using Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model characterized by hyperphagia, obesity, hyperglycemia, hypertension, dyslipidemia and elevated RAS ( Kawano et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0678
Volume/Issue:
Volume 237: Issue 3
Free access
Juthamard Surapongchai Exercise Physiology Laboratory, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand

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Mujalin Prasannarong Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

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Tepmanas Bupha-Intr Exercise Physiology Laboratory, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand

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Vitoon Saengsirisuwan Exercise Physiology Laboratory, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand

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, hypertension, dyslipidemia, obesity and atherosclerosis. A cluster comprising these diabetic and atherogenic risk factors is known as insulin resistance syndrome ( Reaven 2005 , DeFronzo & Tripathy 2009 ). Increasing evidence indicates a link among insulin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0579
Volume/Issue:
Volume 232: Issue 3
Free access
Stephan Werth Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

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Helge Müller-Fielitz Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
CBBM (Center of Brain, Behavior and Metabolism), Lübeck, Germany

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Walter Raasch Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany
CBBM (Center of Brain, Behavior and Metabolism), Lübeck, Germany
DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany

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Introduction The Framingham Offspring Study suggested that increased abdominal fat mass accounts for 65–75% of the risk for hypertension ( Garrison et al. 1987 ). Among other hormonal systems, the renin–angiotensin–aldosterone system (RAAS

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0550
Volume/Issue:
Volume 235: Issue 3
Free access