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Praveen Kumar Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Vishwa Mohan Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Rohit Anthony Sinha Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Megha Chagtoo Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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Madan M Godbole Department of Molecular Medicine and Biotechnology, Department of Biochemistry and Biophysics, Cardiovascular and Metabolic Disorder Program, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India

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having significantly lower binding affinity for ligand-bound TR than for unliganded TR. Similarly, mutant mice lacking interaction of HDAC3 and NCoR also exhibited derepression of several TH-activated genes both in euthyroid and hypothyroid states ( You

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0168
Volume/Issue:
Volume 227: Issue 2
Free access
Patricia C Lisboa Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Avenida 28 de setembro, 87, Rio de Janeiro, RJ 20551‐031, Brazil

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Ellen P S Conceição Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Avenida 28 de setembro, 87, Rio de Janeiro, RJ 20551‐031, Brazil

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Elaine de Oliveira Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Avenida 28 de setembro, 87, Rio de Janeiro, RJ 20551‐031, Brazil

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Egberto G Moura Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Avenida 28 de setembro, 87, Rio de Janeiro, RJ 20551‐031, Brazil

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( Rodrigues et al . 2009 ). It is well known that a disturbance in thyroid function is associated with marked changes in both energy expenditure and body weight. However, to date, there has been no evidence regarding whether this hypothyroidism has biological

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0237
Volume/Issue:
Volume 226: Issue 3
Free access
Nadia Schoenmakers University of Cambridge Metabolic Research Laboratories, Developmental Endocrinology Research Group, Wellcome Trust‐Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Level 4, PO Box 289, Hills Road, Cambridge CB2 0QQ, UK

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Kyriaki S Alatzoglou University of Cambridge Metabolic Research Laboratories, Developmental Endocrinology Research Group, Wellcome Trust‐Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Level 4, PO Box 289, Hills Road, Cambridge CB2 0QQ, UK

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V Krishna Chatterjee University of Cambridge Metabolic Research Laboratories, Developmental Endocrinology Research Group, Wellcome Trust‐Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Level 4, PO Box 289, Hills Road, Cambridge CB2 0QQ, UK

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Mehul T Dattani University of Cambridge Metabolic Research Laboratories, Developmental Endocrinology Research Group, Wellcome Trust‐Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Level 4, PO Box 289, Hills Road, Cambridge CB2 0QQ, UK

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Introduction Central congenital hypothyroidism (CCH) is a rare disorder in which inadequate thyroid hormone biosynthesis occurs due to defective stimulation of a normal thyroid gland by thyroid stimulating hormone (TSH). The underlying molecular

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0341
Volume/Issue:
Volume 227: Issue 3
Open access
C R Liu Key Laboratory of Hormones and Development, Department of Pathology, Ministry of Health China, Endocrinology Institute of Tianjin Medical University, Tianjin Medical Institute, Tianjin 300070, China

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L Y Li
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F Shi
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X Y Zang
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Y M Liu Key Laboratory of Hormones and Development, Department of Pathology, Ministry of Health China, Endocrinology Institute of Tianjin Medical University, Tianjin Medical Institute, Tianjin 300070, China

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Y Sun
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B H Kan
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function. In clinical settings, patients with hyperthyroidism or congenital hypothyroidism (CH) may present abnormalities in myocardial structure and heart function. Changes in thyroid status exert marked influences on the contractile and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0253
Volume/Issue:
Volume 195: Issue 3
Free access
Jitendra Vishwakarma Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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Keerti Gupta Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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Juhi Mishra Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Asmita Garg Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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Rafat Malik Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Amit Kashyap Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Manoj Shukla Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, Uttar Pradesh, India

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Dhirendra Singh Central Pathology Laboratory, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR–IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Sanghamitra Bandyopadhyay Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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.e. hypothyroidism, induces critical damage to the central nervous system (CNS), often resulting in irreversible deficits ( Bernal 2000 , Di Liegro 2008 ). The cerebellum is vital for motor functions, and hypothyroidism impairs motor activity, associated with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0338
Volume/Issue:
Volume 257: Issue 1
Restricted access
Joachim Wistuba Institute of Reproductive Medicine of the University, Domagkstr. 11, 48149 Münster, Germany
Department of Neuroendocrinology, Max-Planck-Institute for Experimental Endocrinology, Feodor-Lynen-Str. 7, 30625 Hannover, Germany

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Jens Mittag Institute of Reproductive Medicine of the University, Domagkstr. 11, 48149 Münster, Germany
Department of Neuroendocrinology, Max-Planck-Institute for Experimental Endocrinology, Feodor-Lynen-Str. 7, 30625 Hannover, Germany

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C Marc Luetjens Institute of Reproductive Medicine of the University, Domagkstr. 11, 48149 Münster, Germany
Department of Neuroendocrinology, Max-Planck-Institute for Experimental Endocrinology, Feodor-Lynen-Str. 7, 30625 Hannover, Germany

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Trevor G Cooper Institute of Reproductive Medicine of the University, Domagkstr. 11, 48149 Münster, Germany
Department of Neuroendocrinology, Max-Planck-Institute for Experimental Endocrinology, Feodor-Lynen-Str. 7, 30625 Hannover, Germany

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Ching-Hei Yeung Institute of Reproductive Medicine of the University, Domagkstr. 11, 48149 Münster, Germany
Department of Neuroendocrinology, Max-Planck-Institute for Experimental Endocrinology, Feodor-Lynen-Str. 7, 30625 Hannover, Germany

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Eberhard Nieschlag Institute of Reproductive Medicine of the University, Domagkstr. 11, 48149 Münster, Germany
Department of Neuroendocrinology, Max-Planck-Institute for Experimental Endocrinology, Feodor-Lynen-Str. 7, 30625 Hannover, Germany

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Karl Bauer Institute of Reproductive Medicine of the University, Domagkstr. 11, 48149 Münster, Germany
Department of Neuroendocrinology, Max-Planck-Institute for Experimental Endocrinology, Feodor-Lynen-Str. 7, 30625 Hannover, Germany

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). The physiological importance of TH becomes most evident under the conditions of congenital hypothyroidism (CH), a common disorder mostly caused by thyroid dysgenesis or agenesis, affecting 1 in 3500 newborns ( Kopp 2002 , De Felice & Di Lauro 2004

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-06-0054
Volume/Issue:
Volume 192: Issue 1
Free access
Camila Calvino
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Luana L Souza
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Ricardo H Costa-e-Sousa
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Norma A S Almeida Laboratório de Endocrinologia Molecular, Departamento de Ciências Fisiológicas da Universidade Federal Rural do Rio de Janeiro, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Edificio do Centro de Ciencias da Saude, Bloco G CEP 21941-902, Rio de Janeiro, Brazil

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Isis H Trevenzoli
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Carmen C Pazos-Moura
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( Seoane et al . 2000 , Ortiga-Carvalho et al . 2002 ). These in vivo and in vitro pituitary effects of leptin upon TSH secretion observed in euthyroid rats were preserved in hyperthyroid rats but not in hypothyroid rats ( Da Veiga et al . 2004

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0476
Volume/Issue:
Volume 215: Issue 1
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S A Lanham
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A L Fowden Bone and Joint Research Group, Department of Physiology, Institute of Developmental Sciences, University of Southampton School of Medicine, Tremona Road, Southampton SO16 6YD, UK

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C Roberts
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C Cooper
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R O C Oreffo
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A J Forhead Bone and Joint Research Group, Department of Physiology, Institute of Developmental Sciences, University of Southampton School of Medicine, Tremona Road, Southampton SO16 6YD, UK

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hormone deficiency for bone development in the fetus. Congenital hypothyroidism (CH) is a condition of thyroid hormone deficiency that affects 1 in 3000–4000 births in the UK and is commonly due to abnormal development of the thyroid gland in the fetus

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0138
Volume/Issue:
Volume 210: Issue 2
Free access
S Iossa
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L Lionetti
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M P Mollica
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A Barletta
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G Liverini
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Abstract

The regulatory and obligatory components of cephalic and gastrointestinal phases of the thermic effect of food (TEF) were measured in control and hypothyroid rats. A significant decrease (P<0·05) in regulatory and obligatory components of cephalic and gastrointestinal TEF, after either a control or energy-dense meal, was found in hypothyroid rats compared with control rats. Our findings indicate that hypothyroidism is associated with a decreased thermogenic response to food which contributes to the reduced energy expenditure of hypothyroid rats. Our results also suggest that tri-iodothyronine is involved in the regulation of postprandial thermogenesis directly as well as through its influence on β-adrenergic response and insulin release.

Journal of Endocrinology (1996) 148, 167–174

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.1480167
Volume/Issue:
Volume 148: Issue 1
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G Şener Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
Department of Radiation Oncology, School of Medicine, Marmara University, Istanbul, Turkey
Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey
Vocational School of Health Related Professions, Marmara University, Istanbul, Turkey
Department of Histology-Embryology, School of Medicine, Marmara University, Istanbul, Turkey
Division of Biochemistry, Kasimpasa Military Hospital, Istanbul, Turkey
Department of Physiology, School of Medicine, Marmara University, Haydarpaşa, Istanbul 34668, Turkey

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L Kabasakal Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
Department of Radiation Oncology, School of Medicine, Marmara University, Istanbul, Turkey
Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey
Vocational School of Health Related Professions, Marmara University, Istanbul, Turkey
Department of Histology-Embryology, School of Medicine, Marmara University, Istanbul, Turkey
Division of Biochemistry, Kasimpasa Military Hospital, Istanbul, Turkey
Department of Physiology, School of Medicine, Marmara University, Haydarpaşa, Istanbul 34668, Turkey

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B M Atasoy Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
Department of Radiation Oncology, School of Medicine, Marmara University, Istanbul, Turkey
Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey
Vocational School of Health Related Professions, Marmara University, Istanbul, Turkey
Department of Histology-Embryology, School of Medicine, Marmara University, Istanbul, Turkey
Division of Biochemistry, Kasimpasa Military Hospital, Istanbul, Turkey
Department of Physiology, School of Medicine, Marmara University, Haydarpaşa, Istanbul 34668, Turkey

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C Erzik Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
Department of Radiation Oncology, School of Medicine, Marmara University, Istanbul, Turkey
Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey
Vocational School of Health Related Professions, Marmara University, Istanbul, Turkey
Department of Histology-Embryology, School of Medicine, Marmara University, Istanbul, Turkey
Division of Biochemistry, Kasimpasa Military Hospital, Istanbul, Turkey
Department of Physiology, School of Medicine, Marmara University, Haydarpaşa, Istanbul 34668, Turkey

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A Velioğlu-Öğünç Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
Department of Radiation Oncology, School of Medicine, Marmara University, Istanbul, Turkey
Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey
Vocational School of Health Related Professions, Marmara University, Istanbul, Turkey
Department of Histology-Embryology, School of Medicine, Marmara University, Istanbul, Turkey
Division of Biochemistry, Kasimpasa Military Hospital, Istanbul, Turkey
Department of Physiology, School of Medicine, Marmara University, Haydarpaşa, Istanbul 34668, Turkey

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Ş Çetinel Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
Department of Radiation Oncology, School of Medicine, Marmara University, Istanbul, Turkey
Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey
Vocational School of Health Related Professions, Marmara University, Istanbul, Turkey
Department of Histology-Embryology, School of Medicine, Marmara University, Istanbul, Turkey
Division of Biochemistry, Kasimpasa Military Hospital, Istanbul, Turkey
Department of Physiology, School of Medicine, Marmara University, Haydarpaşa, Istanbul 34668, Turkey

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G Contuk Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
Department of Radiation Oncology, School of Medicine, Marmara University, Istanbul, Turkey
Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey
Vocational School of Health Related Professions, Marmara University, Istanbul, Turkey
Department of Histology-Embryology, School of Medicine, Marmara University, Istanbul, Turkey
Division of Biochemistry, Kasimpasa Military Hospital, Istanbul, Turkey
Department of Physiology, School of Medicine, Marmara University, Haydarpaşa, Istanbul 34668, Turkey

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N Gedik Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
Department of Radiation Oncology, School of Medicine, Marmara University, Istanbul, Turkey
Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey
Vocational School of Health Related Professions, Marmara University, Istanbul, Turkey
Department of Histology-Embryology, School of Medicine, Marmara University, Istanbul, Turkey
Division of Biochemistry, Kasimpasa Military Hospital, Istanbul, Turkey
Department of Physiology, School of Medicine, Marmara University, Haydarpaşa, Istanbul 34668, Turkey

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B Ç Yeğen Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
Department of Radiation Oncology, School of Medicine, Marmara University, Istanbul, Turkey
Department of Medical Biology, School of Medicine, Marmara University, Istanbul, Turkey
Vocational School of Health Related Professions, Marmara University, Istanbul, Turkey
Department of Histology-Embryology, School of Medicine, Marmara University, Istanbul, Turkey
Division of Biochemistry, Kasimpasa Military Hospital, Istanbul, Turkey
Department of Physiology, School of Medicine, Marmara University, Haydarpaşa, Istanbul 34668, Turkey

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hypothyroidism has been associated with decreased oxidant production and protection against tissue lipid peroxidation ( Swaroop & Ramasarma 1985 , Paller 1986 ). Based on these reports, this study was designed to determine the possible protective effect

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06574
Volume/Issue:
Volume 189: Issue 2
Free access