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Brittany M Duggan Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Daniel M Marko Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Raveen Muzaffar Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Darryl Y Chan Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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Jonathan D Schertzer Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, and Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

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et al. 2009 ). The purpose of this review is to highlight how SMKIs that are often designed for cancer treatment can alter blood glucose and insulin. We apologize that not all relevant literature could be included in this review. We selected specific

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0212
Volume/Issue:
Volume 256: Issue 2
Free access
Linda Ahlkvist Department of Clinical Sciences, Zealand Pharma A/S, Biomedical Center, Lund University, SE 22184 Lund, Sweden

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Bilal Omar Department of Clinical Sciences, Zealand Pharma A/S, Biomedical Center, Lund University, SE 22184 Lund, Sweden

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Anders Valeur Department of Clinical Sciences, Zealand Pharma A/S, Biomedical Center, Lund University, SE 22184 Lund, Sweden

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Keld Fosgerau Department of Clinical Sciences, Zealand Pharma A/S, Biomedical Center, Lund University, SE 22184 Lund, Sweden

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Bo Ahrén Department of Clinical Sciences, Zealand Pharma A/S, Biomedical Center, Lund University, SE 22184 Lund, Sweden

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Introduction Islet dysfunction in type 2 diabetes is bi-hormonal involving both defective insulin secretion and augmented glucagon secretion ( Unger & Orci 1975 ), the latter resulting in chronic elevation of circulating glucagon levels ( Larsson

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0371
Volume/Issue:
Volume 228: Issue 3
Free access
Irena Audzeyenka Laboratory of Molecular and Cellular Nephrology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Gdansk, Poland
Department of Molecular Biotechnology, Faculty of Chemistry, University of Gdansk, Gdansk, Poland

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Patrycja Rachubik Laboratory of Molecular and Cellular Nephrology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Gdansk, Poland

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Dorota Rogacka Laboratory of Molecular and Cellular Nephrology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Gdansk, Poland
Department of Molecular Biotechnology, Faculty of Chemistry, University of Gdansk, Gdansk, Poland

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Moin A Saleem Bristol Renal, University of Bristol, Dorothy Hodgkin Building, Bristol, United Kingdom

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Agnieszka Piwkowska Laboratory of Molecular and Cellular Nephrology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Gdansk, Poland
Department of Molecular Biotechnology, Faculty of Chemistry, University of Gdansk, Gdansk, Poland

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pharmacologically modulated to preserve mitochondrial function in these cells and improve the treatment of kidney diseases in diabetes. Apart from hyperglycemia, early stages of DN are typically characterized by hyperinsulinemia and progressive insulin resistance

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0357
Volume/Issue:
Volume 261: Issue 3
Restricted access
Emma Ahlqvist Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden

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Rashmi B Prasad Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden
Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland

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Leif Groop Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden
Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland

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, reflected by the presence of pancreatic autoantibodies in the blood ( Regnell & Lernmark 2017 ). Identification of such antibodies in plasma or serum is a strong indicator that the patient will eventually need insulin treatment to maintain glucose

Article Type:
Review Article
Collections:
100 years of insulin: A special collection
DOI:
https://doi.org/10.1530/JOE-20-0596
Volume/Issue:
Volume 252: Issue 3
Free access
Liza Margareth Medeiros de Carvalho Sousa Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Renata dos Santos Silva Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Vanessa Uemura da Fonseca Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Rafael Magdanelo Leandro Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Thiago Senna Di Vincenzo Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Ana Bárbara Alves-Wagner Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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Ubiratan Fabres Machado Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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Paula de Carvalho Papa Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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rapidly regulated by insulin ( Uldry & Thorens 2004 ). In CL of dogs, our group has demonstrated a differential expression of glucose transporter 1 ( SLC2A1 /GLUT1), which accompanied hypoxia during the cycle ( Papa et al . 2014 ), pointing out that the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0173
Volume/Issue:
Volume 231: Issue 3
Free access
Philip Newsholme School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Vinicius Cruzat School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Frank Arfuso School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Kevin Keane School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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by the release of the pancreatic hormones insulin and glucagon. These hormones target metabolically active tissues such as muscle, adipose tissue and liver in order to maintain blood glucose concentration within narrow limits (∼4.0–6.0 mmol

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0616
Volume/Issue:
Volume 221: Issue 3
Free access
Sujith Rajan Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Kripa Shankar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Muheeb Beg Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Salil Varshney Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Abhishek Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Ankita Srivastava Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Durgesh Kumar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Raj K Mishra SIPS Superspeciality Hospital, Lucknow, Uttar Pradesh, India

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Zakir Hussain Division of Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Jiaur R Gayen Division of Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Anil N Gaikwad Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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2015). Obesity is defined as excess accumulation of body fat or adipose tissue and is considered to be the antecedent of metabolic disorders such as insulin resistance (IR), type 2 diabetes, hypertension, dyslipidemia, cardiovascular diseases, etc. ( Ye

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0099
Volume/Issue:
Volume 230: Issue 3
Free access
Courtney A Deck Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA
Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina, USA

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Jamie L Mankiewicz Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA
United States Department of Agriculture, Agricultural Research Service, National Center for Cool and Cold Water Aquaculture, Kearneysville, West Virginia, USA

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Russell J Borski Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA

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/db ) animals ( Bray & York 1979 ). Numerous studies report that insulin increases leptin production and secretion from adipose tissue in rodents ( Cusin et al. 1995 , Barr et al. 1997 , Koopmans et al. 1998 ), while Kieffer et al. (1996

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0139
Volume/Issue:
Volume 253: Issue 1
Restricted access
Bee K Tan Warwick Medical School, Department of Obstetrics and Gynaecology, Department of Endocrinology and Metabolic Diseases, University of Warwick, Coventry CV4 7AL, UK
Warwick Medical School, Department of Obstetrics and Gynaecology, Department of Endocrinology and Metabolic Diseases, University of Warwick, Coventry CV4 7AL, UK

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Krzysztof C Lewandowski Warwick Medical School, Department of Obstetrics and Gynaecology, Department of Endocrinology and Metabolic Diseases, University of Warwick, Coventry CV4 7AL, UK

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Joseph Paul O'Hare Warwick Medical School, Department of Obstetrics and Gynaecology, Department of Endocrinology and Metabolic Diseases, University of Warwick, Coventry CV4 7AL, UK

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Harpal S Randeva Warwick Medical School, Department of Obstetrics and Gynaecology, Department of Endocrinology and Metabolic Diseases, University of Warwick, Coventry CV4 7AL, UK

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Introduction Obesity and the metabolic syndrome are associated with insulin resistance, hyperinsulinaemia, type 2 diabetes mellitus (T2DM) and serious cardiovascular sequelae ( Eckel et al . 2005 ). Adipose tissue produces cytokines termed

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0537
Volume/Issue:
Volume 221: Issue 1
Free access
Rafaela Fadoni Alponti Laboratory of Pharmacology, Department of Physiology, Unit of Translational Endocrine Physiology and Pharmacology, Instituto Butantan, Avenida Vital Brasil, 1500, CEP05503‐900 Sao Paulo, Brazil
Laboratory of Pharmacology, Department of Physiology, Unit of Translational Endocrine Physiology and Pharmacology, Instituto Butantan, Avenida Vital Brasil, 1500, CEP05503‐900 Sao Paulo, Brazil

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Patricia Lucio Alves Laboratory of Pharmacology, Department of Physiology, Unit of Translational Endocrine Physiology and Pharmacology, Instituto Butantan, Avenida Vital Brasil, 1500, CEP05503‐900 Sao Paulo, Brazil

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Paulo Flavio Silveira Laboratory of Pharmacology, Department of Physiology, Unit of Translational Endocrine Physiology and Pharmacology, Instituto Butantan, Avenida Vital Brasil, 1500, CEP05503‐900 Sao Paulo, Brazil

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Introduction EC 3.4.11.3 protein (IRAP, insulin-regulated aminopeptidase), also known as vp165, GP160 ( Keller 2004 ), placental leucine aminopeptidase (AP) ( Mizutani et al . 2011 ), cystyl AP, oxytocinase ( Rogi et al . 1996 ), and angiotensin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0266
Volume/Issue:
Volume 228: Issue 2
Free access