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Philip Newsholme School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Vinicius Cruzat School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Frank Arfuso School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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Kevin Keane School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia

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stream, they have an important clinical impact. Diminished glucose-stimulated insulin secretion (GSIS) and β-cell failure correlate with DM development ( Jensen et al . 2008 , Newsholme & Krause 2012 ), and consequently it is important to determine the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0616
Volume/Issue:
Volume 221: Issue 3
Free access
Yusuke Seino Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Takashi Miki Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Wakako Fujimoto Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Eun Young Lee Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Yoshihisa Takahashi Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Kohtaro Minami Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Yutaka Oiso Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Susumu Seino Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Division of Cellular and Molecular Medicine, Departments of Metabolic Medicine, Endocrinology and Diabetes, Department of Medical Physiology, Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

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Introduction Insulin secreted from pancreatic β-cells plays a pivotal role in the maintenance of glucose homeostasis. Insulin secretion is regulated by various factors including nutrients such as glucose, amino acids, and fatty acids

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0579
Volume/Issue:
Volume 218: Issue 1
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Kai-Chun Cheng
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Ying-Xiao Li
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Akihiro Asakawa
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Miharu Ushikai
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Ikuo Kato Department of Psychosomatic Internal Medicine, Department of Bioorganic Chemistry, Department of Medical Research, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan

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Yuki Sato Department of Psychosomatic Internal Medicine, Department of Bioorganic Chemistry, Department of Medical Research, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan

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Juei-Tang Cheng Department of Psychosomatic Internal Medicine, Department of Bioorganic Chemistry, Department of Medical Research, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan

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Akio Inui
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). This peptide belongs to the insulin, gastric intestinal peptide, and endocrine peptide family. Several studies have shown that preptin can enhance insulin secretion, while infusion of isolated pancreases with preptin antibodies significantly reduces

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0176
Volume/Issue:
Volume 215: Issue 1
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Xiaofeng Wang Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2R3

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Catherine B Chan Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2R3

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the context of diabetes mellitus, n-3 PUFAs have anti-inflammatory and insulin-sensitizing functions ( Kalupahana et al . 2011 ). However, the effect of n-3 PUFAs on insulin secretion from pancreatic β-cells is not well recognized. Defects in insulin

Article Type:
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DOI:
https://doi.org/10.1530/JOE-14-0581
Volume/Issue:
Volume 224: Issue 3
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M Schütt
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J Zhou
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M Meier
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H H Klein
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lead to an impairment of insulin secretion. Thus insulin-secretion defects have been observed in mice and beta cells from mice with a beta-cell-specific insulin receptor ( Kido et al. 2000 ) or IRS-1 ( Kulkarni et al. 1999 a , Kido et al. 2000

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05620
Volume/Issue:
Volume 183: Issue 3
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Zhengxiang Huang School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Lili Huang School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Chengjian Wang School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Shanli Zhu School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Xinzhou Qi School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Yang Chen School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Yanjun Zhang School of Information Technology and Electrical Engineering, University of Queensland, St Lucia, Brisbane, Australia

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Michael A Cowley Department of Physiology, Monash University, Melbourne, Australia

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Johannes D Veldhuis Department of Medicine, Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota, USA

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Chen Chen School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Introduction Hormonal disturbance, in either secretion amount or function, often occurs in parallel with impairment of glucose/lipid/protein metabolism in obesity. Two pivotal hormones, insulin and growth hormone (GH), which synergistically

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0385
Volume/Issue:
Volume 245: Issue 1
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Olivier Dumortier Université Côte d’Azur, Inserm, CNRS, IRCAN, Nice, France

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Gaia Fabris Université Côte d’Azur, Inserm, CNRS, IRCAN, Nice, France
Université Côte d’Azur, CNRS, LP2M, Nice, France

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Didier F Pisani Université Côte d’Azur, CNRS, LP2M, Nice, France

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Virginie Casamento Université Côte d’Azur, Inserm, CNRS, IRCAN, Nice, France

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Nadine Gautier Université Côte d’Azur, Inserm, CNRS, IRCAN, Nice, France

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Charlotte Hinault Université Côte d’Azur, CHU, Inserm, CNRS, IRCAN, Nice, France

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Patricia Lebrun Université Côte d’Azur, Inserm, CNRS, IRCAN, Nice, France

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Christophe Duranton Université Côte d’Azur, CNRS, LP2M, Nice, France

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Michel Tauc Université Côte d’Azur, CNRS, LP2M, Nice, France

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Stéphane Dalle INSERM U1191, Institute of Functional Genomics (IGF), CNRS UMR5203, Montpellier University, Montpellier, France

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Julie Kerr-Conte Translational Research for Diabetes, University of Lille, INSERM, CHRU Lille, Lille, France

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François Pattou Translational Research for Diabetes, University of Lille, INSERM, CHRU Lille, Lille, France

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Marc Prentki CRCHUM and Montreal Diabetes Research Center, Departments of Nutrition and Biochemistry and Molecular Medicine, University of Montreal, Montreal, Canada

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Emmanuel Van Obberghen Université Côte d’Azur, CNRS, LP2M, Nice, France
Université Côte d’Azur, CHU, Inserm, CNRS, IRCAN, Nice, France
Université Côte d’Azur, CHU, CNRS, LP2M, Nice, France

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linked to insulin secretion has several exclusive features. First, glucose transport is not limiting for its metabolism, and it results in a rapid equilibrium between intracellular and extracellular glucose at all glycemic levels. The second particular

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Research Article
DOI:
https://doi.org/10.1530/JOE-19-0180
Volume/Issue:
Volume 244: Issue 1
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Daniel Simões Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Patrícia Riva Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Rodrigo Antonio Peliciari-Garcia Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil
Department of Biological Sciences, Laboratory of Biosystems, Federal University of São Paulo, Diadema, São Paulo, Brazil

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Vinicius Fernandes Cruzat Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Maria Fernanda Graciano Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Ana Claudia Munhoz Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Marco Taneda Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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José Cipolla-Neto Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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Angelo Rafael Carpinelli Department of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo, São Paulo, Brazil

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stimulatory effect of melatonin in the pancreas ( Peschke & Peschke 1998 ), there are consistent scientific evidences supporting that melatonin inhibits insulin secretion in islets ( Peschke et al. 2000 ) and clonal beta cell lines ( Mühlbauer & Peschke 2007

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0259
Volume/Issue:
Volume 231: Issue 3
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Olivier Le Bacquer UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

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Gurvan Queniat UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

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Valery Gmyr UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

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Julie Kerr-Conte UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

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Bruno Lefebvre UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

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François Pattou UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

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specific deletion of TSC2 in β-cells induced β-cell apoptosis and reduced insulin secretion, after a first phase of β-cell mass expansion ( Shigeyama et al . 2008 ). In the rat, l -leucine, an amino acid known to induce mTORC1 activation, negatively

Article Type:
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DOI:
https://doi.org/10.1530/JOE-12-0351
Volume/Issue:
Volume 216: Issue 1
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Nguyen Khanh Hoa Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Institute of Material Medica, Hanoi, Vietnam
Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

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Åke Norberg Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Institute of Material Medica, Hanoi, Vietnam
Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

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Rannar Sillard Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Institute of Material Medica, Hanoi, Vietnam
Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

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Dao Van Phan Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Institute of Material Medica, Hanoi, Vietnam
Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

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Nguyen Duy Thuan Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Institute of Material Medica, Hanoi, Vietnam
Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

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Dang Thi Ngoc Dzung Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Institute of Material Medica, Hanoi, Vietnam
Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

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Hans Jörnvall Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Institute of Material Medica, Hanoi, Vietnam
Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

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Claes-Göran Östenson Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Institute of Material Medica, Hanoi, Vietnam
Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

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-cell K-ATP channel (DeFronzo1999, Brown et al. 2004 ). Glucose-stimulated biphasic insulin secretion involves at least two signaling pathways, the K-ATP channel-dependent and K-ATP channel-independent pathways respectively ( Chow et al. 1995

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06948
Volume/Issue:
Volume 192: Issue 2
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