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F A Hills, M G Elder, T Chard and M H F Sullivan

products ( Lewis et al. 1993 ). Candidate trophoblast growth factors include the insulin-like growth factors (IGFs) ( Han et al. 1996 ), and decidual inhibitors may include insulin-like growth factor-binding protein-1 (IGFBP-1) ( Rutanen et al. 1985

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J Cruickshank, D I Grossman, R K Peng, T R Famula and A M Oberbauer

growth hormone (GH) or steroids. The effects of GH are mediated through the actions of insulin-like growth factor-I (IGF-I), a peptide growth factor produced in great abundance by hepatic tissue (reviewed in Le Roith et al. 2001 ). Growth hormone

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Chanika Phornphutkul, Ke-Ying Wu, Xu Yang, Qian Chen and Philip A Gruppuso

Introduction Since the elucidation of the role of insulin-like growth factor-I (IGF-I) in the somatotropic actions of growth hormone (GH), the role of this system in bone growth has been a subject of intense investigation ( Lupu et

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Pablo Mendez, Iñigo Azcoitia and Luis Miguel Garcia-Segura

). In this review we focus on one of the mechanisms of action of oestradiol in the brain: the interaction with the signalling of insulin-like growth factor-I (IGF-I). First, we present several lines of evidence of crosstalk between oestradiol and IGF

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M Shimizu, J T Dickey, H Fukada and W W Dickhoff

Introduction Circulating insulin-like growth factor-I (IGF-I) is bound to a family of six IGF-binding proteins (IGFBPs). Depending on the type of IGFBP and circumstance, they can either inhibit or enhance the growth-promoting actions

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Rupasri Ain, Lindsey N Canham and Michael J Soares

placental growth inhibitory effects of dexamethasone have not been elucidated. Insulin-like growth factor (IGF)-II is a potential target for glucocorticoid actions on placental development. Evidence exists that glucocorticoids regulate IGF

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Motoi Sohmiya and Yuzuru Kato

present study, we investigated the effects of GH and insulin-like growth factor-I (IGF-I) on EPO production in adult rat kidney and liver in vivo and in vitro . Materials and Methods Reagents Recombinant human

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A L Pierce, H Fukada and W W Dickhoff

Introduction The growth hormone (GH)/insulin-like growth factor (IGF) axis is the primary endocrine system that regulates body growth in vertebrates (reviewed in Rosenfeld & Roberts 1999 ). The principal hormones in the GH/IGF axis

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Eddy Himpe, Céline Degaillier, Astrid Coppens and Ron Kooijman

(TNF)/nerve growth factor (NGF) receptor super-family, such as Fas, TNF-related apoptosis-inducing ligand (TNFSF10) receptors, TNFRSF9 (CD137), and the type I TNF receptor ( Simon 2003 ). In a previous study, we showed that insulin-like growth factor

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Sharon Maor, Doris Mayer, Ronit I Yarden, Adrian V Lee, Rive Sarfstein, Haim Werner and Moshe Z Papa

Introduction The insulin-like growth factors, IGF-I and IGF-II, are a family of mitogenic polypeptides with important roles in growth and differentiation. The biological actions of the IGFs are mediated by the IGF-I receptor (IGF