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M B Mazzucco, R Higa, E Capobianco, M Kurtz, A Jawerbaum, and V White

, which leads to enhanced lipid transfer through the placenta to the developing fetus. The placenta acts like a supplier and an exchange organ of oxygen, nutrients, and water. It also provides hormones and growing factors that modulate fetal and placental

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Aldo Grefhorst, Johanna C van den Beukel, Wieneke Dijk, Jacobie Steenbergen, Gardi J Voortman, Selmar Leeuwenburgh, Theo J Visser, Sander Kersten, Edith C H Friesema, Axel P N Themmen, and Jenny A Visser

lipolysis ( Himms-Hagen 1972 ). Cold exposure in rodents has been shown to have profound effects on whole-body lipid metabolism. In particular, cold exposure lowers plasma triglyceride (TG) concentrations by enhancing lipolytic clearance of VLDL TG by BAT

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Hyo Youl Moon, Parkyong Song, Cheol Soo Choi, Sung Ho Ryu, and Pann-Ghill Suh

accumulation of neutral lipids, mainly triglycerides (TGs), without ethanol consumption, viral infection, or other etiologies. NAFLD ranged from simple steatosis to cirrhosis accompanied by oxidative stress and hepatic injury ( Angulo 2002 ). Although the

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Mohamed Asrih and François R Jornayvaz

cellular mechanisms involved in the development of insulin resistance associated with NAFLD, focusing on the role of ectopic lipid deposition in this process, i.e. deposition of lipids outside of the adipose tissue, such as in the liver or skeletal muscle

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Shannon M Bailey, Uduak S Udoh, and Martin E Young

control of carbohydrate, lipid, protein, and NAD + metabolism. Clock control of carbohydrate metabolism Dramatic time-of-day-dependent oscillations in glucose metabolism are observed in both humans and rodent models, at both the whole body level and the

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Michael E Symonds, Mark Pope, Ian Bloor, James Law, Reham Alagal, and Helen Budge

. 2020 ). In one study, daily administration of 100 mg of mirabegron to healthy adult females ( n  = 14) for 4 weeks stimulated brown fat activity, in conjunction with an improved circulating lipid profile and insulin sensitivity ( O’Mara et al. 2020

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Karsten Suhre

’ metabolites have not yet been detected in a biological sample. These ‘expected’ metabolites comprise, in particular, lipid species that are made up of several fatty acid side chains with different chain lengths and degrees of desaturation that may occur in a

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Jung-Yoon Heo, Ji-Eun Kim, Yongwook Dan, Yong-Woon Kim, Jong-Yeon Kim, Kyu Hyang Cho, Young Kyung Bae, Seung-Soon Im, Kwang-Hyeon Liu, In-Hwan Song, Jae-Ryong Kim, In-Kyu Lee, and So-Young Park

independent risk factor for the development of chronic kidney disease ( Laville 2011 , Odagiri et al. 2014 ). One of the proposed mechanisms for obesity-induced chronic kidney disease is lipid accumulation induced by abnormal lipid metabolism, reduced

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Caroline E Geisler and Benjamin J Renquist

have similar histology and disease progression, AFLD also induces molecular and clinical changes that are attributed to high alcohol consumption, and not as a result of hepatic lipid accumulation ( Toshikuni et al. 2014 , Rasineni et al. 2016

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Giselle Adriana Abruzzese, Maria Florencia Heber, Silvana Rocio Ferreira, Leandro Martin Velez, Roxana Reynoso, Omar Pedro Pignataro, and Alicia Beatriz Motta

tissues is unknown. The liver is involved in lipid synthesis, transportation and storage, as well as in glucose and insulin metabolism ( Paschos & Paletas 2009 ), all key factors in PCOS pathogenesis ( den Boer et al . 2004 , Paschos & Paletas 2009