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Department of OB/GYN, Department of OB/GYN, NorthShore University HealthSystem, 2650 Ridge Avenue, Evanston, Illinois 60201, USA
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Department of OB/GYN, Department of OB/GYN, NorthShore University HealthSystem, 2650 Ridge Avenue, Evanston, Illinois 60201, USA
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, in the mammary gland ( Santos et al . 2009 ). Feng et al . (2014) demonstrated diminished progesterone receptor membrane component 1 (PGRMC1) at the rupture site among preterm prelabor rupture of membranes (PPROM) subjects compared with preterm
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glucocorticoid receptor ( Kontula et al . 1983 ), voltage-gated and Ca 2+ -activated K + channels ( Ehring et al . 1998 ), or another yet unidentified membrane delimited mechanism ( Gamberucci et al . 2004 ). Recently, a novel membrane progesterone receptor
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. 1999 , Patrat et al. 2000 , Somanath et al. 2000 , Jang & Yi 2002 ), which strongly implies that progesterone exerts its effect on mammalian spermatozoa non-genomically via a still unidentified membrane-bound progesterone receptor (mPR). Although
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Introduction The single transmembrane protein progesterone receptor membrane component 1 (PGRMC1) is a 25–28 kDa protein that possesses a cytochrome b -like heme-binding domain and belongs to the membrane-associated progesterone receptor (MAPR
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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, progestagenic compounds use the progesterone receptor (PR). Post-translational modifications such as sumoylation and phosphorylation have been shown to alter PR transcriptional activity. Phosphorylation of PR Ser-294 augments PR degradation by the 26S proteasome
Marine Science Institute, University of Texas at Austin, 750 Channelview Drive, Port Aransas, Texas 78373, USA
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Marine Science Institute, University of Texas at Austin, 750 Channelview Drive, Port Aransas, Texas 78373, USA
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Marine Science Institute, University of Texas at Austin, 750 Channelview Drive, Port Aransas, Texas 78373, USA
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Marine Science Institute, University of Texas at Austin, 750 Channelview Drive, Port Aransas, Texas 78373, USA
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Research 38 2434 –2437. Karteris E , Zervou S, Pang Y, Dong J, Hillhouse EW, Randeva HS & Thomas P 2006 Progesterone signaling in human myometrium through two novel membrane G protein coupled receptors: potential role in
Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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Inpharmatica Ltd, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, UK
Biomedical Research Institute, Department of Biological Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Cancer Research-UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Endokrinologikum Hamburg, Falkenried 88, 20251 Hamburg, Germany
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effects are thought to be initiated at the cell surface by unique membrane receptors, although there is compelling evidence that some of the rapid, post-transcriptional progesterone actions involve activation of ‘classical’ steroid receptors
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forskolin, an activator of adenylate cyclase, promotes trophoblast fusion and production of hCG and P4 in primary CTs and the trophoblast-derived choriocarcinoma cell line BeWo ( Tuckey 2005 ). Progesterone receptor membrane component 1 (PGRMC1) is a
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the cell surface through binding to membrane estrogen receptors ( Kelly & Levin 2001 , Levin & Hammes 2016 ). Although it was demonstrated that membrane-initiated signaling could be mediated by the classic receptors ERα and ERβ trafficked to the cell
Department of Physiology, University of La Laguna, La Laguna, Spain
Department of Comparative Pathology, University of Córdoba, Córdoba, Spain
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Department of Physiology, University of La Laguna, La Laguna, Spain
Department of Comparative Pathology, University of Córdoba, Córdoba, Spain
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Department of Physiology, University of La Laguna, La Laguna, Spain
Department of Comparative Pathology, University of Córdoba, Córdoba, Spain
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Department of Physiology, University of La Laguna, La Laguna, Spain
Department of Comparative Pathology, University of Córdoba, Córdoba, Spain
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Department of Physiology, University of La Laguna, La Laguna, Spain
Department of Comparative Pathology, University of Córdoba, Córdoba, Spain
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Department of Physiology, University of La Laguna, La Laguna, Spain
Department of Comparative Pathology, University of Córdoba, Córdoba, Spain
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Department of Physiology, University of La Laguna, La Laguna, Spain
Department of Comparative Pathology, University of Córdoba, Córdoba, Spain
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Department of Physiology, University of La Laguna, La Laguna, Spain
Department of Comparative Pathology, University of Córdoba, Córdoba, Spain
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Department of Physiology, University of La Laguna, La Laguna, Spain
Department of Comparative Pathology, University of Córdoba, Córdoba, Spain
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Department of Physiology, University of La Laguna, La Laguna, Spain
Department of Comparative Pathology, University of Córdoba, Córdoba, Spain
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-induced upregulation of progesterone receptor (PR) in gonadotropes ( Turgeon & Waring 1992 , Sánchez-Criado et al. 2002 , Bellido et al. 2003 ). Activation of the complete oestrogen receptor (ER) orchestra after 3-day administration of oestrogen in rats 2 weeks