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Prenatal androgen exposure programs metabolic dysfunction in female mice

Alison V Roland Departments of, Medicine, Cell Biology, University of Virginia, PO Box 800578, Charlottesville, Virginia 22908, USA

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Craig S Nunemaker Departments of, Medicine, Cell Biology, University of Virginia, PO Box 800578, Charlottesville, Virginia 22908, USA

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Susanna R Keller Departments of, Medicine, Cell Biology, University of Virginia, PO Box 800578, Charlottesville, Virginia 22908, USA
Departments of, Medicine, Cell Biology, University of Virginia, PO Box 800578, Charlottesville, Virginia 22908, USA

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Suzanne M Moenter Departments of, Medicine, Cell Biology, University of Virginia, PO Box 800578, Charlottesville, Virginia 22908, USA
Departments of, Medicine, Cell Biology, University of Virginia, PO Box 800578, Charlottesville, Virginia 22908, USA

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16–19) overlaps ours. Hence, the steroid may be most important in establishing differences among models. In this study, we have shown that prenatal androgens program long-term alterations in metabolic function in female mice. These findings have

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0217
Volume/Issue:
Volume 207: Issue 2
Free access

Prenatal androgen excess programs metabolic derangements in pubertal female rats

Xiaonan Yan State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China

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Xiaonan Dai State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China

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Jing Wang State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China

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Nannan Zhao State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China

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Yugui Cui State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China

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Jiayin Liu State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China

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substantiate the hypothesis that an early perturbation due to in utero androgen excess resets the reproductive and metabolic trajectory of the growing fetus and programs target tissue differentiation and development, supporting a potential role of epigenetics

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0577
Volume/Issue:
Volume 217: Issue 1
Free access

The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can ω3 polyunsaturated fatty acids prevent adverse programming outcomes?

Miao Hou Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Chenlin Ji Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Jing Wang Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Yanhua Liu Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Bin Sun Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Mei Guo Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Jonas Burén Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Xiaonan Li Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China
Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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evidence indicates that the early nutritional status of an organism may be a programming factor for the development of obesity and metabolic syndrome later in life ( Ong & Loos 2006 , Symonds et al . 2009 ), particularly malnutrition or overnutrition

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0191
Volume/Issue:
Volume 215: Issue 1
Free access

Intrauterine malnutrition disrupts leptin and ghrelin milk hormones, programming rats

Jocemara Patrícia Silva de Souza Parrela Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Ingridys Regina Borkenhagen Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Sarah Ramany Faria Salmeron Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Thalyne Aparecida Leite Lima Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Ginislene Dias Souza Miranda Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Hercules de Oliveira Costermani Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Camila Luiza Rodrigues dos Santos Ricken Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Ester Vieira Alves Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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Rodrigo Mello Gomes Laboratory of Endocrine Physiology and Metabolism, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Goiás, Brazil

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Júlio Cezar de Oliveira Research Group on Perinatal Programming of Metabolic Diseases: DOHaD Paradigm, Laboratory of Metabolic and Cardiovascular Diseases, Health Education and Research Center (NUPADS), Institute of Health Sciences, Federal University of Mato Grosso, University Campus of Sinop, Sinop, Mato Grosso, Brazil

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et al. 1997 ) famine studies has shown that maternal undernutrition programs long-term metabolic dysfunction in the offspring and that some subtle characteristics of this metabolic impairment depend on the period when the maternal undernutrition

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0427
Volume/Issue:
Volume 255: Issue 1
Restricted access

Paternal diabetes programs sex-dependent placental alterations and fetal overgrowth

Daiana Fornes Universidad de Buenos Aires, Facultad de Medicina, Buenos Aires, Argentina
CONICET – Universidad de Buenos Aires, Laboratory of Reproduction and Metabolism, CEFYBO, Buenos Aires, Argentina

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Florencia Heinecke Universidad de Buenos Aires, Facultad de Medicina, Buenos Aires, Argentina
CONICET – Universidad de Buenos Aires, Laboratory of Programming of Metabolic Anomalies, CEFYBO, Buenos Aires, Argentina

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Cintia Romina Gatti Universidad de Buenos Aires, Facultad de Medicina, Buenos Aires, Argentina
CONICET – Universidad de Buenos Aires, Laboratory of Reproduction and Metabolism, CEFYBO, Buenos Aires, Argentina

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Sabrina Lorena Roberti Universidad de Buenos Aires, Facultad de Medicina, Buenos Aires, Argentina
CONICET – Universidad de Buenos Aires, Laboratory of Reproduction and Metabolism, CEFYBO, Buenos Aires, Argentina

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Verónica White Universidad de Buenos Aires, Facultad de Medicina, Buenos Aires, Argentina
CONICET – Universidad de Buenos Aires, Laboratory of Programming of Metabolic Anomalies, CEFYBO, Buenos Aires, Argentina

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Alicia Jawerbaum Universidad de Buenos Aires, Facultad de Medicina, Buenos Aires, Argentina
CONICET – Universidad de Buenos Aires, Laboratory of Reproduction and Metabolism, CEFYBO, Buenos Aires, Argentina

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Evangelina Capobianco Universidad de Buenos Aires, Facultad de Medicina, Buenos Aires, Argentina
CONICET – Universidad de Buenos Aires, Laboratory of Reproduction and Metabolism, CEFYBO, Buenos Aires, Argentina

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developing obesity, diabetes, hypertension and cardiovascular diseases ( Barker 2006 ). It is thus clear that the maternal environment plays a dominant role in programming adult-onset diseases in the offspring. However, although the paternal metabolic status

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0301
Volume/Issue:
Volume 254: Issue 1
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Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance

Antonio Gonzalez-Bulnes
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Susana Astiz
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Cristina Ovilo Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Clemente J Lopez-Bote Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Raul Sanchez-Sanchez
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Maria L Perez-Solana
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Laura Torres-Rovira Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Miriam Ayuso Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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Jorge Gonzalez Departamento de Reproducción Animal, Departamento de Mejora Genética Animal, Facultad de Veterinaria, Micros Veterinaria, INIA, Avenida Puerta de Hierro s/n, Madrid 28040, Spain

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, the concept of the Developmental Origin of Health and Disease ( Gluckman & Hanson 2004 ) proposes that changes in the intrauterine environment modify the metabolic status of the foetus, and thereby prenatal programming, play a key role in juvenile

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0217
Volume/Issue:
Volume 223: Issue 1
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Leptin and insulin in young adulthood are associated with weight in infancy

Umberto Simeoni Division of Pediatrics & DOHaD Laboratory, CHUV University Hospital and University of Lausanne, Lausanne, Switzerland

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Clive Osmond MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK

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Ricardo Garay Craven, Villemoisson-sur-Orge, France

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Christophe Buffat Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital de la Conception, Marseille, France

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Farid Boubred Division of Neonatology, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Christophe Chagnaud Division of Radiology and Medical Imaging, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Elisabeth Jouve UPCET, Clinical Pharmacology, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Christine Audebert UPCET, Clinical Pharmacology, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Jean-Michel Antoine Danone Institute International, Paris, France

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Kent Thornburg Bob and Charlee Moore Institute for Nutrition and Wellness, Oregon Health & Science University, Portland, Oregon, USA

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range have been shown to be sufficient to influence the cardio-metabolic risk ( Barker et al. 1989 ). However little is known on developmental programming that occurs under the influence of variations in what is considered the normal environment, and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0538
Volume/Issue:
Volume 244: Issue 2
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RISING STARS: Mechanistic insights into maternal–fetal cross talk and islet beta-cell development

Seokwon Jo Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Emilyn U Alejandro Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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the tissues of the developing offspring are programmed. Because of this, if important metabolic tissues like the pancreas are programmed incorrectly during these critical periods, it can potentially lead to lasting impacts on the health trajectory and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0069
Volume/Issue:
Volume 259: Issue 3
Open access

Developmental programming of insulin resistance: are androgens the culprits?

Muraly Puttabyatappa Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA

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Robert M Sargis Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Vasantha Padmanabhan Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA

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bioavailability as well as those that modulate androgen receptor signaling, are also potential contributors to androgenic programming of metabolic disorders such as insulin resistance ( Diamanti-Kandarakis et al. 2009 , Gore et al. 2015 ). Rapid

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0044
Volume/Issue:
Volume 245: Issue 3
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Epigenetic responses and the developmental origins of health and disease

Dipali Goyal School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA

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Sean W Limesand School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA

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Ravi Goyal School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA

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, Jang et al. 2015 , Agarwal et al. 2018 , Ducsay et al. 2018 , Lecoutre et al. 2018 ). A factor that has received increasing attention, in this regard, is the idea of ‘developmental programming’ during fetal life, as a consequence of maternal

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0009
Volume/Issue:
Volume 242: Issue 1
Free access