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Da-Long Ren
Da-Long Ren
Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China
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Ai-Ai Sun
Ai-Ai Sun
Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China
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Ya-Juan Li
Ya-Juan Li
Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China
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Min Chen
Min Chen
Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China
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Shu-Chao Ge
Shu-Chao Ge
Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China
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Bing Hu
Bing Hu
Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Hefei, Anhui Province 230026, People's Republic of China
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regulating role in neutrophil migration ( Ren et al . 2015 ), and this finding motivated us to further explore the potential effect of exogenous melatonin on neutrophil function. Thus, this study aimed to investigate, in vivo , the effect of exogenous
Sun-O Ka
Sun-O Ka
Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea
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Mi-Young Song
Mi-Young Song
Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea
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Eun Ju Bae
Eun Ju Bae
Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea
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Byung-Hyun Park
Byung-Hyun Park
Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea
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regulates macrophage locomotion in response to metabolic stresses remains unclear. Cell migration is a complicated process regulated by the activation of various signaling molecules. Results from several studies have indicated that nuclear factor kappa B
Keisuke Ishizawa
Keisuke Ishizawa
Pharmacology, Medical Pharmacology, Departments of
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Narantungalag Dorjsuren
Narantungalag Dorjsuren
Pharmacology, Medical Pharmacology, Departments of
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Yuki Izawa-Ishizawa
Yuki Izawa-Ishizawa
Pharmacology, Medical Pharmacology, Departments of
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Rika Sugimoto
Rika Sugimoto
Pharmacology, Medical Pharmacology, Departments of
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Yasumasa Ikeda
Yasumasa Ikeda
Pharmacology, Medical Pharmacology, Departments of
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Yoshitaka Kihira
Yoshitaka Kihira
Pharmacology, Medical Pharmacology, Departments of
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Kazuyoshi Kawazoe
Kazuyoshi Kawazoe
Pharmacology, Medical Pharmacology, Departments of
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Shuhei Tomita
Shuhei Tomita
Pharmacology, Medical Pharmacology, Departments of
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Koichiro Tsuchiya
Koichiro Tsuchiya
Pharmacology, Medical Pharmacology, Departments of
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Kazuo Minakuchi
Kazuo Minakuchi
Pharmacology, Medical Pharmacology, Departments of
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Toshiaki Tamaki
Toshiaki Tamaki
Pharmacology, Medical Pharmacology, Departments of
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, Ouedraogo et al . 2006 ). In in vitro studies, adiponectin has been reported to inhibit platelet-derived growth factor (PDGF)- or heparin-binding epidermal growth factor-like growth factor-induced vascular smooth muscle cell (VSMC) migration ( Arita et
Huali Yu
Huali Yu
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Ye Guo
Ye Guo
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Yang Zhao
Yang Zhao
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Feng Zhou
Feng Zhou
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Kehan Zhao
Kehan Zhao
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Mayuqing Li
Mayuqing Li
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Junxiong Wen
Junxiong Wen
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Zixuan He
Zixuan He
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Xiaojuan Zhu
Xiaojuan Zhu
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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Xiaoxiao He
Xiaoxiao He
Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China
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suppresses neuronal migration ( Fukumoto et al. 2009 ), which is a key step in establishing correct cortical lamination. Cortical neurons originating from the ventricular zone (VZ) and subventricular zone (SVZ) follow an inside–out pattern to reach their
Yuichiro Takeuchi
Yuichiro Takeuchi
Department of Aging Medicine and Geriatrics, Graduate School of Medicine, Shinshu University, 3-1-1, Asahi, Matsumoto-Shi, Nagano 390-8621, Japan
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Keishi Yamauchi
Keishi Yamauchi
Department of Aging Medicine and Geriatrics, Graduate School of Medicine, Shinshu University, 3-1-1, Asahi, Matsumoto-Shi, Nagano 390-8621, Japan
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Junko Nakamura
Junko Nakamura
Department of Aging Medicine and Geriatrics, Graduate School of Medicine, Shinshu University, 3-1-1, Asahi, Matsumoto-Shi, Nagano 390-8621, Japan
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Satoshi Shigematsu
Satoshi Shigematsu
Department of Aging Medicine and Geriatrics, Graduate School of Medicine, Shinshu University, 3-1-1, Asahi, Matsumoto-Shi, Nagano 390-8621, Japan
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Kiyoshi Hashizume
Kiyoshi Hashizume
Department of Aging Medicine and Geriatrics, Graduate School of Medicine, Shinshu University, 3-1-1, Asahi, Matsumoto-Shi, Nagano 390-8621, Japan
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hypertensive hormone, AngII has various biological effects on cell proliferation, migration, and invasion. Locally or systematically generated AngII influences vascular function in both physiological and pathological states via several mechanisms, such as
Hyo Youl Moon
Hyo Youl Moon
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Parkyong Song
Parkyong Song
BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea
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Cheol Soo Choi
Cheol Soo Choi
BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea
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Sung Ho Ryu
Sung Ho Ryu
BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea
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Pann-Ghill Suh
Pann-Ghill Suh
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) ( Ruderman & Prentki 2004 ). Based on the requirement for AMPK to alleviate hepatic steatosis, there is growing demand to identify mediators of AMPK activation in response to dynamic physiological activity. Although macrophage migration inhibitory factor (MIF
Véronique Serre-Beinier
Véronique Serre-Beinier
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Christian Toso
Christian Toso
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Philippe Morel
Philippe Morel
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Carmen Gonelle-Gispert
Carmen Gonelle-Gispert
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Christelle Veyrat-Durebex
Christelle Veyrat-Durebex
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Françoise Rohner-Jeanrenaud
Françoise Rohner-Jeanrenaud
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Thierry Calandra
Thierry Calandra
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Thierry Roger
Thierry Roger
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Richard W James
Richard W James
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Xavier Montet
Xavier Montet
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Léo Bühler
Léo Bühler
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Domenico Bosco
Domenico Bosco
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Thierry Berney
Thierry Berney
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
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Introduction Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in both innate and adaptive immunity. Originally described as a T-cell-derived product, MIF has now been shown to be released by numerous cell types and
Jorge Diaz
Jorge Diaz
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Evelyn Aranda
Evelyn Aranda
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Soledad Henriquez
Soledad Henriquez
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Marisol Quezada
Marisol Quezada
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Estefanía Espinoza
Estefanía Espinoza
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Maria Loreto Bravo
Maria Loreto Bravo
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Bárbara Oliva
Bárbara Oliva
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Soledad Lange
Soledad Lange
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Manuel Villalon
Manuel Villalon
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Marius Jones
Marius Jones
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Jan J Brosens
Jan J Brosens
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Sumie Kato
Sumie Kato
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Mauricio A Cuello
Mauricio A Cuello
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Todd P Knutson
Todd P Knutson
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Carol A Lange
Carol A Lange
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Lisette Leyton
Lisette Leyton
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Gareth I Owen
Gareth I Owen
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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Departamento de Fisiología, Departamento de Ginecología, Clinical Sciences Research Laboratories, Departments of Medicine and Pharmacology, Centro de Estudios Moleculares de la Célula (CEMC), Biomedical Research Consortium (BMRC) Chile, Facultad de Ciencias Biológicas and
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has been speculated that progestins hijack these signaling pathways in breast cancer cells. Progesterone and progestins have been previously reported to stimulate breast cancer cell migration and invasion ( Carvajal et al . 2005 , Kato et al . 2005
JA Baugh
JA Baugh
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SC Donnelly
SC Donnelly
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The diverse actions of macrophage migration inhibitory factor (MIF) within the immuno-neuroendocrine system are yet to be fully understood, but it is clear that MIF plays a pivotal role in the regulation of both the innate and adaptive immune response. An emerging body of data presently indicates that MIF's position within the cytokine cascade is to act in concert with glucocorticoids to control the 'set point' and magnitude of the immune and inflammatory response. In this article we will review the actions of MIF within the immune system and discuss the overlapping and contrasting aspects of MIF and glucocorticoid biology. In particular we will focus on the role of MIF within the immuno-neuroendocrine interface and suggest molecular mechanisms by which MIF may counter-regulate glucocorticoid function. Finally we will discuss emerging evidence that functional MIF gene-promoter polymorphisms render one susceptible to elevated MIF expression, and the development of an exaggerated immune/inflammatory response that potentiates the progression to chronic inflammatory disease.
RP Donn
RP Donn
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DW Ray
DW Ray
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The immunological and neuroendocrine properties of macrophage migration inhibitory factor (MIF) are diverse. In this article we review the known cellular, molecular and genetic properties of MIF that place it as a key regulatory cytokine, acting within both the innate and adaptive immune responses.The unexpected and paradoxical induction of MIF secretion by low concentrations of glucocorticoids is explored. The role of MIF as a locally acting modulator of glucocorticoid sensitivity within foci of inflammation is also discussed. MIF has no homology with any other pro-inflammatory cytokine and until recently lacked a recognised transmembrane receptor. MIF has also been shown to be directly taken up into target cells and to interact with intracellular signalling molecules, including the Jun activation domain-binding protein Jab-1.Comprehensive analysis of the MIF gene has identified important functional polymorphisms and a series of genetic studies has revealed both association and linkage of MIF with inflammatory diseases. Altered MIF regulation may therefore be pivotal to acquiring chronic inflammation following an innate immune response.
