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luteal cells and CL tissues and the effect of PGF 2 α on the apoptosis of luteal cells is mediated by the Slit/Robo interaction. Materials and methods Reagents Rabbit IgG anti-Slit2 polyclonal antibodies and mouse IgM anti-Robo1 MABs were

. 1998 , Saito et al . 2007 ). During the gestation period, I do was strongly expressed in the mouse concepti and placenta from days 8.5 to 12.5 of post-coitus ( Suzuki et al . 2001 , Minatogawa et al . 2003 ). Unexpectedly, tryptophan

mouse ( Wharfe et al. 2016 ), and Wharfe and coworkers have also previously demonstrated that clock gene rhythms in the rat liver are altered by pregnancy ( Wharfe et al. 2011 ). Additionally, despite the high estradiol levels during pregnancy, the

per week using a Bayer Glucometer Elite. A mouse was deemed diabetic after two consecutive BG readings of >250 mg/dl. Mice were housed in accordance with the Ohio State University's requirements and regulations for animal care and use. Mice were

effects that reduce their use in clinic. In this review, we discuss the cell-specific contribution of PPARγ in hepatic pathophysiology by using mechanistic mouse studies. PPARs were identified as orphan receptors and tested with reverse endocrinology

types of acute or chronic stressors, CBG expression was found to be downregulated, thereby increasing free GC levels ( Neufeld et al . 1994 , Fleshner et al . 1995 , Spencer et al . 1996 ). Recently, the analysis of a mouse model of targeted CBG

context of the observed in vivo tissue distribution of PANDER. Therefore, to further elucidate the physiologic role of pancreas-secreted PANDER in vivo , our laboratory has created and phenotyped the only transgenic mouse model (PANDER transgenic, PANTG

). Therefore, investigating whether xenotransplanted rat BAT faces immunorejection remains important. In this study, we tested rat-to-mouse (RTM) BAT transplantation in 2-month-old pubescent mice. For comparison, we performed parallel mouse-to-mouse BAT

identification of extreme skeletal phenotypes in mutant mouse lines that carry single-gene knockouts representing all the known protein-coding genes. This approach has been made possible by the International Knockout Mouse Consortium (IKMC), whose aim is to

-thickness excisional skin wounding was performed as previously described ( Mirza et al. 2013 ). Four 8-mm excisional wounds were made on the back of each mouse with a dermal biopsy punch, and wounds were covered with Tegaderm (3M, Saint Paul, Minnesota, US). Tegaderm