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XueJing Zhang
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JianHua Li State Key Laboratory of Agrobiotechnology, Center of Reproductive Medicine and Genetics, College of Biological Sciences, China Agricultural University, No. 2 Yuanmingyuan Xilu, Beijing 100193, People's Republic of China

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JiaLi Liu
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HaoShu Luo
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KeMian Gou
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Sheng Cui
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luteal cells and CL tissues and the effect of PGF 2 α on the apoptosis of luteal cells is mediated by the Slit/Robo interaction. Materials and methods Reagents Rabbit IgG anti-Slit2 polyclonal antibodies and mouse IgM anti-Robo1 MABs were

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Dang-Dang Li College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Ying-Jie Gao College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Xue-Chao Tian College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Zhan-Qing Yang College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Hang Cao College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Qiao-Ling Zhang College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Bin Guo College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Zhan-Peng Yue College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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. 1998 , Saito et al . 2007 ). During the gestation period, I do was strongly expressed in the mouse concepti and placenta from days 8.5 to 12.5 of post-coitus ( Suzuki et al . 2001 , Minatogawa et al . 2003 ). Unexpectedly, tryptophan

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Cassandra C Yap School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Michaela D Wharfe School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Peter J Mark School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Brendan J Waddell School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Jeremy T Smith School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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mouse ( Wharfe et al. 2016 ), and Wharfe and coworkers have also previously demonstrated that clock gene rhythms in the rat liver are altered by pregnancy ( Wharfe et al. 2011 ). Additionally, despite the high estradiol levels during pregnancy, the

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Bernard Freudenthal Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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John Logan Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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Sanger Institute Mouse Pipelines Mouse Pipelines, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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Peter I Croucher Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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Graham R Williams Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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J H Duncan Bassett Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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identification of extreme skeletal phenotypes in mutant mouse lines that carry single-gene knockouts representing all the known protein-coding genes. This approach has been made possible by the International Knockout Mouse Consortium (IKMC), whose aim is to

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Elizabeth S Barrie The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Mels Lodder The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Paul H Weinreb The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Jill Buss The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Amer Rajab The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Christopher Adin The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Qing-Sheng Mi The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Gregg A Hadley The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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per week using a Bayer Glucometer Elite. A mouse was deemed diabetic after two consecutive BG readings of >250 mg/dl. Mice were housed in accordance with the Ohio State University's requirements and regulations for animal care and use. Mice were

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J Manolopoulou Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany

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M Bielohuby Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany
Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany

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S J Caton Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany

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C E Gomez-Sanchez Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany

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I Renner-Mueller Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany

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E Wolf Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany

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U D Lichtenauer Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany

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F Beuschlein Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany

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A Hoeflich Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany
Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany

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M Bidlingmaier Medizinische Klinik Innenstadt, Institute of Molecular Animal Breeding and Biotechnology, Division of Endocrinology, Institute for Molecular Medicine and Cell Research, Laboratory of Mouse Genetics, Ludwig-Maximilians University, Ziemssenstr. 1, 80336 Munich, Germany

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. 2001 , Vinson 2003 , 2004 ). However, genetically altered animal models which are of increasing importance for intervention studies and to establish a genotype–phenotype relationship are restricted to the mouse ( Peters et al . 1999 , 2007

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Samuel M Lee Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Jose Muratalla Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Marta Sierra-Cruz Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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Jose Cordoba-Chacon Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA

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effects that reduce their use in clinic. In this review, we discuss the cell-specific contribution of PPARγ in hepatic pathophysiology by using mechanistic mouse studies. PPARs were identified as orphan receptors and tested with reverse endocrinology

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Gabriele E Mattos
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Jan-Michael Heinzmann
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Stefanie Norkowski
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Jean-Christophe Helbling Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Amandine M Minni Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Marie-Pierre Moisan Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany
Max Planck Institute of Psychiatry, Institut National de la Recherche Agronomique (INRA), University of Bordeaux, Research Group of Psychoneuroendocrinology, Kraepelinstrasse 2-10, 80804 Munich, Germany

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Chadi Touma
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types of acute or chronic stressors, CBG expression was found to be downregulated, thereby increasing free GC levels ( Neufeld et al . 1994 , Fleshner et al . 1995 , Spencer et al . 1996 ). Recently, the analysis of a mouse model of targeted CBG

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Claudia E Robert-Cooperman
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Grace C Dougan Department of Cell Biology, Department of Pediatrics, Microbiology and Molecular Biology, University of South Florida, 4202 East Fowler Avenue, BSF 206, Tampa, Florida 33620, USA

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Shari L Moak
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Mark G Athanason
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Melanie N Kuehl
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Harris Bell-Temin
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Stanley M Stevens Jr
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Brant R Burkhardt
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context of the observed in vivo tissue distribution of PANDER. Therefore, to further elucidate the physiologic role of pancreas-secreted PANDER in vivo , our laboratory has created and phenotyped the only transgenic mouse model (PANDER transgenic, PANTG

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Lei Du State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Yang Wang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Cong-Rong Li State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Liang-Jian Chen State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Jin-Yang Cai State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Zheng-Rong Xia Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Wen-Tao Zeng Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China

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Zi-Bin Wang Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Xi-Chen Chen Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Fan Hu State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Dong Zhang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China

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Xiao-Wei Xing The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Zhi-Xia Yang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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). Therefore, investigating whether xenotransplanted rat BAT faces immunorejection remains important. In this study, we tested rat-to-mouse (RTM) BAT transplantation in 2-month-old pubescent mice. For comparison, we performed parallel mouse-to-mouse BAT

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