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XueJing Zhang, JianHua Li, JiaLi Liu, HaoShu Luo, KeMian Gou, and Sheng Cui

luteal cells and CL tissues and the effect of PGF 2 α on the apoptosis of luteal cells is mediated by the Slit/Robo interaction. Materials and methods Reagents Rabbit IgG anti-Slit2 polyclonal antibodies and mouse IgM anti-Robo1 MABs were

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Dang-Dang Li, Ying-Jie Gao, Xue-Chao Tian, Zhan-Qing Yang, Hang Cao, Qiao-Ling Zhang, Bin Guo, and Zhan-Peng Yue

. 1998 , Saito et al . 2007 ). During the gestation period, I do was strongly expressed in the mouse concepti and placenta from days 8.5 to 12.5 of post-coitus ( Suzuki et al . 2001 , Minatogawa et al . 2003 ). Unexpectedly, tryptophan

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Cassandra C Yap, Michaela D Wharfe, Peter J Mark, Brendan J Waddell, and Jeremy T Smith

mouse ( Wharfe et al. 2016 ), and Wharfe and coworkers have also previously demonstrated that clock gene rhythms in the rat liver are altered by pregnancy ( Wharfe et al. 2011 ). Additionally, despite the high estradiol levels during pregnancy, the

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Elizabeth S Barrie, Mels Lodder, Paul H Weinreb, Jill Buss, Amer Rajab, Christopher Adin, Qing-Sheng Mi, and Gregg A Hadley

per week using a Bayer Glucometer Elite. A mouse was deemed diabetic after two consecutive BG readings of >250 mg/dl. Mice were housed in accordance with the Ohio State University's requirements and regulations for animal care and use. Mice were

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Samuel M Lee, Jose Muratalla, Marta Sierra-Cruz, and Jose Cordoba-Chacon

effects that reduce their use in clinic. In this review, we discuss the cell-specific contribution of PPARγ in hepatic pathophysiology by using mechanistic mouse studies. PPARs were identified as orphan receptors and tested with reverse endocrinology

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Gabriele E Mattos, Jan-Michael Heinzmann, Stefanie Norkowski, Jean-Christophe Helbling, Amandine M Minni, Marie-Pierre Moisan, and Chadi Touma

types of acute or chronic stressors, CBG expression was found to be downregulated, thereby increasing free GC levels ( Neufeld et al . 1994 , Fleshner et al . 1995 , Spencer et al . 1996 ). Recently, the analysis of a mouse model of targeted CBG

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Claudia E Robert-Cooperman, Grace C Dougan, Shari L Moak, Mark G Athanason, Melanie N Kuehl, Harris Bell-Temin, Stanley M Stevens Jr, and Brant R Burkhardt

context of the observed in vivo tissue distribution of PANDER. Therefore, to further elucidate the physiologic role of pancreas-secreted PANDER in vivo , our laboratory has created and phenotyped the only transgenic mouse model (PANDER transgenic, PANTG

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Lei Du, Yang Wang, Cong-Rong Li, Liang-Jian Chen, Jin-Yang Cai, Zheng-Rong Xia, Wen-Tao Zeng, Zi-Bin Wang, Xi-Chen Chen, Fan Hu, Dong Zhang, Xiao-Wei Xing, and Zhi-Xia Yang

). Therefore, investigating whether xenotransplanted rat BAT faces immunorejection remains important. In this study, we tested rat-to-mouse (RTM) BAT transplantation in 2-month-old pubescent mice. For comparison, we performed parallel mouse-to-mouse BAT

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Bernard Freudenthal, John Logan, Sanger Institute Mouse Pipelines, Peter I Croucher, Graham R Williams, and J H Duncan Bassett

identification of extreme skeletal phenotypes in mutant mouse lines that carry single-gene knockouts representing all the known protein-coding genes. This approach has been made possible by the International Knockout Mouse Consortium (IKMC), whose aim is to

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Rita E Roberts, Jacqueline Cavalcante-Silva, Rhonda D Kineman, and Timothy J Koh

-thickness excisional skin wounding was performed as previously described ( Mirza et al. 2013 ). Four 8-mm excisional wounds were made on the back of each mouse with a dermal biopsy punch, and wounds were covered with Tegaderm (3M, Saint Paul, Minnesota, US). Tegaderm