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Rebecca M Reynolds University/British Heart Foundation Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Adrienne Gordon Charles Perkins Centre, University of Sydney, Sydney, Australia

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. 2017 ). Obesity impacts on health of women across their reproductive lifespan with adverse effects on not only fertility and short-term complications of pregnancy, but also on longer-term health outcomes for both women and their children. Here, we

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Michaela D Wharfe School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Peter J Mark School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Caitlin S Wyrwoll School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Jeremy T Smith School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Cassandra Yap School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Michael W Clarke School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Brendan J Waddell School of Anatomy, Metabolomics Australia, Physiology and Human Biology, The University of Western Australia, M309, Perth 6009, Australia

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Introduction Maternal physiological adaptations are central to pregnancy success, balancing fetal and placental demands with the maintenance of maternal homeostasis. Among these maternal adaptations, enhanced activity of the hypothalamic

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Caitlin S Wyrwoll School of Human Sciences, University of Western Australia, Crawley, Western Australia, Australia
Telethon Kids Institute, Perth, Australia
Healthy Environments and Lives (HEAL) Network

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ramifications for offspring health in later life. Her recent research focuses on the environmental change (particularly heat exposure and drinking water quality) on maternal adaptations to pregnancy and child health outcomes. This work is becoming increasingly

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Derek S Boeldt Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Mary A Grummer Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Ronald R Magness Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA
Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA
Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Ian M Bird Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA
Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Introduction Pregnancy is a time of dramatic vascular adaptation. Through initial angiogenesis and then sustained vasodilation, the pregnant uterus achieves the biggest drop in vascular resistance of any organ system. This in turn promotes a

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Harleen Kaur Robinson Research Institute, University of Adelaide, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia

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Beverly S Muhlhausler CSIRO Nutrition and Health, Adelaide, Australia

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Claire T Roberts Robinson Research Institute, University of Adelaide, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia
College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia

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Kathryn L Gatford Robinson Research Institute, University of Adelaide, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia

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Introduction The GH–IGF axis is essential for growth and development before and after birth and has important anabolic and metabolic functions in adults. Its role during pregnancy has been less understood and is the primary focus of this

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Cassandra C Yap School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Michaela D Wharfe School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Peter J Mark School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Brendan J Waddell School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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Jeremy T Smith School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Western Australia, Australia

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mouse ( Wharfe et al. 2016 ), and Wharfe and coworkers have also previously demonstrated that clock gene rhythms in the rat liver are altered by pregnancy ( Wharfe et al. 2011 ). Additionally, despite the high estradiol levels during pregnancy, the

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Amanda K Mauro Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Nauman Khurshid Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Danielle M Berdahl Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Amanda C Ampey Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Daniel Adu Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Department of Pediatrics, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Dinesh M Shah Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Derek S Boeldt Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Introduction Preeclampsia (PE) is a hypertensive disorder of pregnancy that occurs in 5–8% of all pregnancies. Significant morbidities can occur to the mother and fetus, and in extreme cases, death can result. Mothers who develop PE and babies

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Ankana Ganguly Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK

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Jennifer A Tamblyn Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK
CEDAM, Birmingham Health Partners, The University of Birmingham, Birmingham, UK

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Sarah Finn-Sell Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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Shiao-Y Chan Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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Melissa Westwood Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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Janesh Gupta Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK

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Mark D Kilby Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK

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Stephane R Gross School of Life and Health Sciences, Aston University, Birmingham, UK

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Martin Hewison Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
CEDAM, Birmingham Health Partners, The University of Birmingham, Birmingham, UK

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addition to facilitating a good maternal blood supply for nutrition–waste exchange and orchestrating endocrine mediators of pregnancy to maintain maternal physiological changes for an optimal environment for fetal development, the placenta also acts to

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Harleen Kaur Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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Beverly S Muhlhausler Food and Nutrition Research Group, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia
Nutrition and Health Program, Health and Biosecurity Business Unit, Commonwealth Scientific and Industrial Research Organisation, Adelaide, Australia

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Pamela Su-Lin Sim Food and Nutrition Research Group, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia

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Amanda J Page Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Hui Li Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Maria Nunez-Salces Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Georgia S Clarke Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia
Nutrition, Diabetes & Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia

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Lili Huang School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Rebecca L Wilson Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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Johannes D Veldhuis Endocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota, USA

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Chen Chen School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia

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Claire T Roberts Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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Kathryn L Gatford Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia

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Introduction Successful pregnancy requires substantial maternal physiological adaptations, including increases in food intake, to maintain maternal health and allow optimal growth of the feto-placental unit to term. Growth hormone (GH) is a

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Hui Yu Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Zoe Thompson Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Sylee Kiran Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
School of Literature, Science, and Arts, University of Michigan, Ann Arbor, Michigan, USA

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Graham L Jones Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, USA

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Lakshmi Mundada Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Surbhi Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Marcelo Rubinstein Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas and Facultad de Ciencias Exactas y Naturales, Universidad de Buenos, Buenos Aires, Argentina

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Malcolm J Low Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

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). LEPRE might buffer leptin signaling by reducing its renal clearance under normal physiological conditions and prevent excessive binding of elevated circulating leptin to LEPRB in extreme metabolic conditions, such as late pregnancy ( Tu et al . 2008

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