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Laura E Pascal, Khalid Z Masoodi, June Liu, Xiaonan Qiu, Qiong Song, Yujuan Wang, Yachen Zang, Tiejun Yang, Yao Wang, Lora H Rigatti, Uma Chandran, Leandro M Colli, Ricardo Z N Vencio, Yi Lu, Jian Zhang and Zhou Wang

inhibited the growth of xenograft tumors ( Xiao et al . 2003 ). Eaf2 -knockout mice developed high-grade murine prostatic intraepithelial neoplasia (mPIN) and increased vascularity in several murine strains ( Xiao et al. 2008 , Pascal et al . 2013

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Takumi Takeuchi, Motofumi Suzuki, Jimpei Kumagai, Toshiyuki Kamijo, Masato Sakai and Tadaichi Kitamura

). As shown in Fig. 4a , b, and e, prostatic dorsal lobes of dermatopontin transgenic mouse lines 2 and 8 showed prostate intraepithelial neoplasia (PIN) at the age of 11 months ( n =3 for each line), but control littermates did not. PIN was diagnosed

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Hong-Zhi Sun, Tong-Wei Yang, Wei-Jin Zang and Shu-Fang Wu

in the development and progression of PCa. NFKB is overexpressed in prostatic intraepithelial neoplasia and prostate adenocarcinoma ( Sweeney et al . 2004 ). Constitutive activation of NFKB has been found in androgen-independent PCa cells, whereas

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Stina Häggström Rudolfsson and Anders Bergh

testosterone-stimulated prostate growth in adult rats . Prostate 67 573 – 581 . Harvey H 1995 A unifying hypthesis that links benign prostate hyperplasia and prostatic intraepithelial neoplasia with prostate cancer . Pathology, Research and Practice 191 924

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A Stigliano, O Gandini, L Cerquetti, P Gazzaniga, S Misiti, S Monti, A Gradilone, P Falasca, M Poggi, E Brunetti, A M Aglianò and V Toscano

were isolated under a pathologist’s supervision and used as control. In all these samples, the presence of benign prostatic hyperplasia (BPH) or prostatic intraepithelial neoplasia (PIN) was excluded. RNA extraction and RT

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Nariaki Fujimoto, Yukimi Akimoto, Tomoharu Suzuki, Shigeyuki Kitamura and Shigeru Ohta

preferentially occur. For instance, the TRAMP transgenic line expresses the SV40 antigen under the control of the rat probasin promoter. The TRAMP mice develop high-grade prostatic intraepithelial neoplasia and prostate cancer within 12 weeks of birth, and

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Ashley Gray, William J Aronson, R James Barnard, Hemal Mehta, Junxiang Wan, Jonathan Said, Pinchas Cohen and Colette Galet

) mice (C57BL/6; Leu et al . 2003 ). c-Myc mice develop murine prostatic intraepithelial neoplasia (mPIN) as early as 2–4 weeks of age and the transition to invasive adenocarcinoma occurs between 3 and 6 months. The goal of this study was to evaluate

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Kelly Coffey and Craig N Robson

, SENP1 has been found to be overexpressed in prostatic intraepithelial neoplasia (PIN) and PC, and transgenic mice overexpressing SENP1 in the prostate were found to have early PIN development ( Cheng et al . 2006 ). AR PTMs and Kennedy's disease Early

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Marlise Guerrero Schimpf, María M Milesi, Enrique H Luque and Jorgelina Varayoud

) and intraepithelial neoplasia in the prostate ( Ho et al. 2006 ). Similarly, mice postnatally exposed to low doses of DES with an enhanced uterine response to E2 at puberty ( Newbold et al. 2004 ) developed uterine endometrial adenocarcinoma later

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Shahenda M El-Naggar, Mohammad T Malik, Alvin Martin, Joseph P Moore, Mary Proctor, Tariq Hamid and Sham S Kakar

, Febbo PG, Kum J, Xue Q, Bikoff R, Ma H, Kantoff PW, Golub TR et al . 2003 Prostate intraepithelial neoplasia induced by prostate restricted Akt activation. PNAS 100 , 7841 –7846. Malik MT & Kakar SS 2006 Regulation