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Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Yiliyasi Mayila, Rie Yanagihara, Yuri Yamamoto, Akira Kuwahara, and Minoru Irahara

pathogenesis or phenotypes of PCOS in animal models. The physiological, metabolic and reproductive changes related to DOHaD can be reproduced in some animal models. In mice and rats, the offspring of undernourished mothers tend to exhibit obesity and insulin

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Benjamin J Lamont and Sofianos Andrikopoulos

sought to review the available data from in vivo preclinical studies utilising GLP1R agonists or DPP4 inhibitors. GLP1R agonists and β -cell mass Can GLP1R agonists affect β-cell mass in normal rodents? Normal rats One of the earliest studies to

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Aiying Liu, Liping Gao, Shoulei Kang, Ying Liu, Chuanying Xu, Hong Sun, Dongye Li, and Changdong Yan

the Medical College of Xuzhou. Seventy-day-old female Sprague–Dawley rats (Clean grade, Xuzhou Medical College, China) weighing 180–200 g were randomly divided into two groups. One group was Sham operated and received daily injections of vehicle and

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Martina Holubová, Jana Zemenová, Barbora Mikulášková, Vladimíra Panajotova, Jiří Stöhr, Martin Haluzík, Jaroslav Kuneš, Blanka Železná, and Lenka Maletínská

best animal obesity models are often diet-induced ones, as they result in changes consistent with those seen in obese patients ( Vickers et al . 2011 ). Diet-induced obese (DIO) rats or mice are produced generally from lean animals that have free

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Florencia Figueroa, Gisela Mendoza, Darío Cardozo, Fabián Mohamed, Liliana Oliveros, and Myriam Forneris

functional significance of the ovary peripheral innervation in the pathogenesis of reproductive endocrine disorders. In rats, most of the sympathetic fibers innervating the ovaries arise from the superior mesenteric/celiac plexus ganglia and reach the ovary

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Renato Simões Gaspar, Renata Ohana Alves Benevides, João Lucas de Lima Fontelles, Caroline Castro Vale, Lucas Martins França, Paulo de Tarso Silva Barros, and Antonio Marcus de Andrade Paes

). The association between MetS risk factors, especially obesity and insulin resistance, and ovarian dysfunction has been reported in female mice ( Wu et al . 2014 b ), rats ( Sanchez-Garrido et al . 2015 ), and mini pigs ( Newell-Fugate et al . 2014

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Wanpitak Pongkan, Hiranya Pintana, Sivaporn Sivasinprasasn, Thidarat Jaiwongkam, Siriporn C Chattipakorn, and Nipon Chattipakorn

. 2008 , Oskui et al. 2013 ). Moreover, testosterone deprivation alone significantly induces left ventricular (LV) contractile dysfunction and cardiac sympathovagal imbalance in orchiectomized rats ( Pongkan et al. 2015 ). Obesity is one of the

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Xiaonan Yan, Xiaonan Dai, Jing Wang, Nannan Zhao, Yugui Cui, and Jiayin Liu

, sheep, rats, and mice manifest most of the reproductive and metabolic derangements observed in women with PCOS ( Forsdike et al . 2007 , Abbott et al . 2008 a , b , 2009 , Padmanabhan et al . 2010 , Roland et al . 2010 , Tyndall et al . 2012

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Myat Theingi Swe, Laongdao Thongnak, Krit Jaikumkao, Anchalee Pongchaidecha, Varanuj Chatsudthipong, and Anusorn Lungkaphin

examined. The aim of the current study was to investigate the effect of dapagliflozin on the expression levels of renal cortical gluconeogenic enzymes in high-fat diet-fed obese rats. In addition, the possible underlying molecular mechanisms by which

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Kok-Min Seow, Jyun-Lin Lee, Ming-Luen Doong, Seng-Wong Huang, Jiann-Loung Hwang, Wei-Ju Huang, Full-Young Chang, Low-Tone Ho, and Chi-Chang Juan

ovariectomized (Ovx) rats and to clarify the role of CCK and its receptors in regulating the effect of hCG on gastrointestinal transit. Furthermore, estrogen is important for maintaining normal uterine weight. Ovariectomy of rats without estrogen supplementation