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Kazunari Nohara, Suhuan Liu, Matthew S Meyers, Aurélie Waget, Mathieu Ferron, Gérard Karsenty, Rémy Burcelin and Franck Mauvais-Jarvis

significant. Results Hypogonadotropic hypogonadism and altered hypothalamic KiSS1 regulation in NTM To determine the pathophysiological consequences of neonatal androgenization on reproduction and metabolism in males, we compared littermate control male mice

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Farid F Chehab

Introduction The survival of any species depends on its ability to reproduce, otherwise it will become extinct. Reproduction is an energy-demanding process and its physiological costs vary widely in the animal kingdom, but there is no doubt that the

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Anne M Houbrechts, Jolien Van houcke and Veerle M Darras

Introduction Vertebrate reproduction is controlled by several endocrine factors, among which thyroid hormones (THs) are indispensable. They play an essential role in gametogenesis, steroidogenesis, embryogenesis, fetal development and growth

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Almas R Juma, Pauliina E Damdimopoulou, Sylvia V H Grommen, Wim J M Van de Ven and Bert De Groef

PLAG1 in the endocrine systems coordinating growth and reproduction in particular. Molecular biology of PLAG1 Gene and protein structure of PLAG1 The PLAG1 gene is located on human chromosome 8q12. Although the predominant PLAG1 transcript is 7.3 kb

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F Wahab, M Shahab and R Behr

Introduction Reproduction in nonprimate mammals and in primates is highly responsive to metabolic alterations ( Cameron 1991 , Wade & Jones 2004 ). Deficiencies of metabolic fuels prevent the proper release of gonadotropin releasing hormone (GnRH

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Patrycja A Jazwiec and Deborah M Sloboda

disease risk. The hypothesis that the early life environment influences later life disease susceptibility is now recognized as the Developmental Origins of Health and Disease (DOHaD). Programming reproduction It is now known that non

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Sharon H Chou and Christos Mantzoros

of the interactions of leptin with the hypothalamic–pituitary–gonadal axis. Leptin stimulates POMC/CART and Glut neurons and inhibits AgRP/NPY and GABA neurons to modulate reproduction centrally. At the ovaries, leptin can have different effects

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Taeko Nishiwaki-Ohkawa and Takashi Yoshimura

photoperiodism ( Bünning 1969 ). Many biological processes are photoperiodic, for example, flowering and dormancy in plants ( Heino et al . 2010 , Izawa 2010 , Putterill et al . 2010 ), as well as reproduction, diapause ( Saunders 2010 ), migration ( Saunders

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Christopher A Price

Keratinocyte growth factor and its receptor in human ovaries from fetuses, girls and women . Molecular Human Reproduction 15 69 – 75 . ( doi:10.1093/molehr/gan080 ) Allen BL Rapraeger AC 2003 Spatial and temporal expression of heparan sulfate in

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S P Sivarajasingam, N Imami and M R Johnson

, Campbell S, Stewart CJR, Cameron IT, Greer IA & Norman JE, Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process, Human Reproduction , 1999, volume 14, issue 1, pages 229–236, by permission