low physical activity ( Fried et al. 2001 ). Loss of muscle mass (atrophy) is an inevitable, although somewhat modifiable, process that occurs with ageing ( Sayer et al. 2008 ), when it is referred to as primary sarcopenia. In contrast, secondary
Mark E Cleasby, Pauline M Jamieson, and Philip J Atherton
A M Solomon and P M G Bouloux
Notch signalling pathway in sarcopenia of ageing. In elegant parabiotic experiments, younger and older animals’ circulations were exchanged, with the Notch pathway appearing to be reactivated in older mice exposed to ‘young’ serum, suggesting a role for
Sebastio Perrini, Luigi Laviola, Marcos C Carreira, Angelo Cignarelli, Annalisa Natalicchio, and Francesco Giorgino
Introduction Age-related muscle wasting and sarcopenia are characterized by the loss of skeletal muscle mass with a gradual decline in muscle function, including a decrease in power-producing capacity, contraction, and relaxation, but also by
Melissa F Jackson, Dung Luong, Dor Dor Vang, Dilip K Garikipati, James B Stanton, O Lynne Nelson, and Buel D Rodgers
Introduction The aging process is the physiological accumulation of changes over time and is unfortunately associated with increased disease susceptibility. Sarcopenia, the age-related and progressive loss of skeletal muscle mass and function
Lucía Pronsato, Ricardo Boland, and Lorena Milanesi
Introduction The loss of muscle mass and strength with aging, also referred to as sarcopenia, is a highly prevalent condition among the elderly and predicts several adverse outcomes, including disability, institutionalization, and mortality. Age
Pegah JafariNasabian, Julia E Inglis, Wendimere Reilly, Owen J Kelly, and Jasminka Z Ilich
b ). On the contrary, both muscle and bone tissues decrease with age. Muscle mass peaks at the age of approximately 30 years and then gradually declines. There is about 20–40% decrease in muscle mass by the age of 70 years, leading to sarcopenia
Hassina Ould Hamouda, Bernadette Delplanque, Yacir Benomar, Delphine Crépin, Laure Riffault, Pascale LeRuyet, Cécile Bonhomme, and Mohammed Taouis
have been made to improve diet protein composition in order to increase the accretion of muscle proteins and to slow sarcopenia ( Guillet et al . 2004 , Paddon-Jones et al . 2004 , Katsanos et al . 2005 , Hirabara et al . 2013 ). Different
Takuro Okamura, Yoshitaka Hashimoto, Takafumi Osaka, Takafumi Senmaru, Takuya Fukuda, Masahide Hamaguchi, and Michiaki Fukui
muscle index (SMI) based on algorithms proposed by the Asian Working Group for Sarcopenia ( Chen et al . 2014 ). The body composition of each patient was evaluated using a multifrequency impedance body composition analyzer (InBody 720, InBody Japan
Felipe de Oliveira Franco, Magno Alves Lopes, Felipe dos Santos Henriques, Rodrigo Xavier das Neves, Cesário Bianchi Filho, and Miguel Luiz Batista Jr
M 2016 Cachexia-associated adipose tissue morphological rearrangement in gastrointestinal cancer patients . Journal of Cachexia, Sarcopenia and Muscle 7 37 – 47 . ( doi:10.1002/jcsm.12037 ) Beluzi M Peres SB Henriques FS
Yuriko Kitajima and Yusuke Ono
and C ). This phenomenon was not observed in any other types of muscle weakness such as age-related sarcopenia and disuse-induced muscle atrophy. The pathophysiological significance of this increase in myonuclei in terms of muscle function was unclear
