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Adina Maniu Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Graham W Aberdeen Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Terrie J Lynch Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA

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Jerry L Nadler Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA

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Soon O K Kim Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA

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Michael J Quon Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Gerald J Pepe Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA

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Eugene D Albrecht Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

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& Korach 2006 , Heldring et al . 2007 , Wiik et al . 2009 ). Estradiol stimulates insulin sensitivity and enhances glucose tolerance in skeletal muscle of adult mice ( Gao et al . 2006 , Lundholm et al . 2008 , Riant et al . 2009 ) and protects

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0530
Volume/Issue:
Volume 230: Issue 2
Free access
Ulla Simanainen
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Yan Ru (Ellen) Gao
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Reena Desai
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Mark Jimenez
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Jennifer Spaliviero
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Janet R Keast ANZAC Research Institute, Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales 2139, Australia

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David J Handelsman
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sensitivity Androgen sensitivity in the male mice was determined following castration to remove the endogenous source of androgens and treatment with fixed androgen levels produced by dihydrotestosterone (DHT) implants (DHT clamp; Simanainen et al . (2011

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0056
Volume/Issue:
Volume 218: Issue 2
Free access
Qinghua Wang State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, Jiangsu, China
Laboratory Animal Center, Nantong University, Nantong, Jiangsu, China

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Jing Tang State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, Jiangsu, China

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Shujun Jiang State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, Jiangsu, China
School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, Jiangsu, China

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Zan Huang State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, Jiangsu, China
Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China

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Anying Song State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, Jiangsu, China

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Siyuan Hou State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, Jiangsu, China

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Xiang Gao State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, Jiangsu, China

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Hai-Bin Ruan Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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the top and average levels shown at the bottom. Data presented as mean ±  s.e.m. * P  < 0.05, ** P  < 0.01 and *** P  < 0.001 by two-tailed t -test. Improved glucose metabolism and insulin sensitivity in MAGED1 KO mice Activation of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0349
Volume/Issue:
Volume 239: Issue 2
Free access
Ellen H Stolte Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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B M Lidy Verburg van Kemenade Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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Huub F J Savelkoul Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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Gert Flik Department of Animal Physiology, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands

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-inflammatory properties of GCs make them a first-choice medication for asthma ( Walsh 2005 ) and rheumatoid arthritis ( Boers 2004 ). However, there is considerable individual variation in sensitivity to GCs ( Hearing et al. 1999 ), which may affect the outcome of GC

Article Type:
Review Article
DOI:
https://doi.org/10.1677/joe.1.06703
Volume/Issue:
Volume 190: Issue 1
Free access
Charlene Diepenbroek Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, the Netherlands

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Leslie Eggels Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, the Netherlands

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Mariëtte T Ackermans Department of Clinical Chemistry, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, the Netherlands

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Eric Fliers Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, the Netherlands

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Andries Kalsbeek Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, the Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands

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Mireille J Serlie Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, the Netherlands

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Susanne E la Fleur Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, the Netherlands

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Introduction The prevalence of type 2 diabetes mellitus (T2DM), associated with obesity, is taking epidemic proportions. The molecular drivers involved in the pathogenesis of lower insulin sensitivity in obesity include, but are not limited to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0265
Volume/Issue:
Volume 232: Issue 1
Free access
Holly M Johnson The University of Sydney, Charles Perkins Centre, School of Life and Environmental Sciences, Sydney, New South Wales, Australia

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Erin Stanfield The University of Sydney, Charles Perkins Centre, School of Life and Environmental Sciences, Sydney, New South Wales, Australia

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Grace J Campbell The University of Sydney, Charles Perkins Centre, School of Life and Environmental Sciences, Sydney, New South Wales, Australia

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Erica E Eberl The University of Sydney, Charles Perkins Centre, School of Life and Environmental Sciences, Sydney, New South Wales, Australia

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Gregory J Cooney The University of Sydney, Charles Perkins Centre, School of Medical Sciences, Sydney, New South Wales, Australia

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Kim S Bell-Anderson The University of Sydney, Charles Perkins Centre, School of Life and Environmental Sciences, Sydney, New South Wales, Australia

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exert varying effects on insulin sensitivity measured under hyperinsulinaemic-euglycaemic clamp conditions ( Storlien et al. 1987 ). Much research has been fat-focused and concentrated on the association of ectopic lipid with the development of insulin

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0566
Volume/Issue:
Volume 241: Issue 3
Free access
Fernando Escrivá Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

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M Lucía Gavete Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

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Yasmín Fermín Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

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Coralia Pérez Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

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Nilda Gallardo Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

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Carmen Alvarez Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

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Antonio Andrés Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

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Manuel Ros Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

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José M Carrascosa Departamento de Bioquímica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Centro de Biología Molecular ‘Severo Ochoa’, Facultad de Ciencias, Universidad Autónoma, Campus de Cantoblanco, 28049 Madrid, Spain
Area de Bioquímica, Facultad de Químicas, Centro Regional de Investigaciones Biomédicas (CRIB), Universidad de Castilla La Mancha, 13071 Ciudad Real, Spain
Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain

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Introduction Ageing is associated with a moderate decrease in peripheral insulin sensitivity in humans ( De Fronzo 1981 , Fink et al. 1983 , Rowe et al. 1983 ) and rodents ( Goodman et al. 1983 , Narimiya et al. 1984

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.07043
Volume/Issue:
Volume 194: Issue 1
Free access
P. I. ADNITT
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SUMMARY

Insulin sensitivity was increased in rats treated for 21 days with mebanazine, 10mg./kg., phenelzine, 30mg./kg., or tranylcypromine, 10 mg./kg. but not in rats treated with isonicotinic acid hydrazide, 10 mg./kg., for 21 days or in animals treated with a single injection of mebanazine, 10 mg./kg. Pargyline, 14 mg./kg., given for 21 days produced 83% inhibition of hepatic monoamineoxidase and had a hypoglycaemic action when compared with 0·15 mg. mebanazine/kg., a dose just less than that required to inhibit monoamineoxidase. Increased insulin sensitivity seemed to be related to chronic inhibition of monoamineoxidase rather than to administration of hydrazine derivatives.

There was a tendency to anorexia during the drug treatment, but rats treated with monoamineoxidase inhibitors gained less weight than pair-fed control animals. This could be due to the previously reported reduction in growth hormone activity during treatment with monoamineoxidase inhibitors; nevertheless, any explanation for the increase in insulin sensitivity should be based upon the monoamineoxidase-inhibiting action of these drugs.

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.0420417
Volume/Issue:
Volume 42: Issue 3
Restricted access
Le Bu
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Qian Yao Department of Endocrinology, Key Laboratory of Sichuan Province of Medicinal Chemistry, Department of Endocrinology, Shanghai 10th People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, China

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Zhimin Liu Department of Endocrinology, Key Laboratory of Sichuan Province of Medicinal Chemistry, Department of Endocrinology, Shanghai 10th People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, China

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Wei Tang Department of Endocrinology, Key Laboratory of Sichuan Province of Medicinal Chemistry, Department of Endocrinology, Shanghai 10th People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, China

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Junjie Zou Department of Endocrinology, Key Laboratory of Sichuan Province of Medicinal Chemistry, Department of Endocrinology, Shanghai 10th People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, China

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Shen Qu
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insulin sensitivity. First, high levels of galanin receptors are found in the skeletal muscle and adipose tissue of rats ( Li et al . 2004 ), i.e. the key sites involved in regulating glucose disposal and insulin sensitivity. Second, diabetic rats have an

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0444
Volume/Issue:
Volume 221: Issue 1
Free access
Margaret K Hahn Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada

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Adria Giacca Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Sandra Pereira Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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with those used in humans to understand the translatability of metabolic tests. Determining insulin sensitivity and glucose metabolism in vivo Glucose tolerance test The glucose tolerance test (GTT) assesses the response (i.e. circulating

Article Type:
Review Article
Collections:
Insulin resistance and type 2 diabetes mellitus
DOI:
https://doi.org/10.1530/JOE-23-0308
Volume/Issue:
Volume 260: Issue 3
Open access