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Rong Wan, Chao Zhu, Rui Guo, Lai Jin, Yunxin Liu, Li Li, Hao Zhang, and Shengnan Li

biology, such as modulating local and systemic inflammation. Importantly, both AR and urocortin (UCN1) have been identified in vascular ECs ( Liu et al . 2003 , Kageyama et al . 2012 ). Endothelial UCN1 is upregulated by inflammatory cytokines ( Kohno

Open access

Sian J S Simpson, Lorna I F Smith, Peter M Jones, and James E Bowe

Introduction The corticotropin-releasing hormone (CRH) peptide family comprises CRH and the structurally related urocortin peptides (UCN1, UCN2 and UCN3). These neuroendocrine peptides are best known for their involvement in regulating the

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Kenichiro Watanabe, Takahiro Nemoto, Shigeo Akira, Toshiyuki Takeshita, and Tamotsu Shibasaki

& Vale 2006 ). Urocortin 2 (Ucn2) is a member of the CRF peptide family, which acts through binding to CRF type 2 receptor (CRF-R2). Others and we previously demonstrated that Ucn2 is expressed in both the brain and peripheral tissues, including the lung

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Pasquale Florio, Giulia De Falco, Eleonora Leucci, Michela Torricelli, Paulo B Torres, Paolo Toti, Arianna Dell’Anna, Ennio Tiso, Rosa Santopietro, Lorenzo Leoncini, and Felice Petraglia

and secretion of these factors may be involved in pathological conditions, such as endometrial adenocarcinoma. Among the locally produced brain peptides, urocortin (UCN) is one of the most recently identified. It is a 40-amino acid neuropeptide

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Takahiro Nemoto, Azusa Iwasaki-Sekino, Naoko Yamauchi, and Tamotsu Shibasaki

Introduction As a member of the corticotropin-releasing factor (CRF) family peptides, urocortin (Ucn 1) was discovered by screening of a rat brain cDNA library with a probe derived from carp urotensin I ( Vaughan et al. 1995

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Yuqing Wu, Yinyan Xu, Hong Zhou, Jin Tao, and Shengnan Li

exerts profound immunosuppressive effects ( Chrousos 1995 ). More recently, a new member of the CRH family, urocortin (UCN), was cloned and shown to be expressed in the central nervous system of rats ( Vaughan et al. 1995 ) and man ( Donaldson et

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Takahiro Nemoto, Naoko Yamauchi, and Tamotsu Shibasaki

actions of CRF are induced through two subtypes of CRF receptor (CRF-R), the CRF-R1 and the CRF-R2, with a higher affinity to CRF-R1 than to CRF-R2 ( Chen et al . 1993 , Perrin et al . 1993 , Lovenberg et al . 1995 a ). Urocortins 2 (Ucn 2), one of

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Manon M Roustit, Joan M Vaughan, Pauline M Jamieson, and Mark E Cleasby

treatments available. However, recent work has demonstrated that generalised overexpression of urocortin 3 (UCN3) in mice results in both hypertrophy and increased glucose disposal into muscle ( Jamieson et al . 2011 ), making this an interesting candidate

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Jessica L Huang, Sharon Lee, Pelle Hoek, Talitha van der Meulen, Richard Van, and Mark O Huising

, most beta cells do not express MAFA at this early age and remain largely functionally immature. Additional markers, such as the peptide hormone Urocortin 3 (UCN3), have emerged as late beta cell maturity markers in recent years. UCN3 is a member of

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Christopher J Charles, David L Jardine, Miriam T Rademaker, and A Mark Richards

Introduction Emerging evidence suggests that the urocortin (UCN) peptides UCN1, UCN2, and UCN3, recently identified members of the corticotropin-releasing factor (CRF) peptide family, contribute to pressure and volume regulation with possible