Melatonin receptors in the human fetal kidney: 2-[125I]iodomelatonin binding sites correlated with expression of Mel1a and Mel1b receptor genes

in Journal of Endocrinology
Authors:
JE Drew
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LM Williams
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LT Hannah
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P Barrett
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DR Abramovich
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DOI:
https://doi.org/10.1677/joe.0.1560261
Volume/Issue:
Volume 156: Issue 2
Article Type:
Other
Page Range:
261–267
Online Publication Date:
01 Feb 1998
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Melatonin receptors in the human fetal kidney were identified and characterized by quantitative in vitro autoradiography using the melatonin agonist, 2-[125I]iodomelatonin. Specific binding was localized to cells in the nephrogenic region at the outer perimeter of the developing kidney and was time-dependent, saturable and inhibited in the presence of guanosine 5'-0-(3-thiotriphosphate) indicative of a G protein-coupled receptor. Expression of the Mel1a and Mel1b melatonin receptors in human fetal kidney was determined using RT-PCR. In situ hybridization confirmed the localization of the Mel1a mRNA transcripts. A role for melatonin in development of the human fetal kidney is postulated.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
7
Article Type:
Other
Print Publication Date:
01 Feb 1998
Online Publication Date:
01 Feb 1998