Effects of corticotropin-releasing factor on feeding and pancreatic polypeptide response in the dog

in Journal of Endocrinology
Authors:
M Okita
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A Inui
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T Inoue
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H Mizuuchi
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K Banno
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S Baba
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M Kasuga
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DOI:
https://doi.org/10.1677/joe.0.1560359
Volume/Issue:
Volume 156: Issue 2
Article Type:
Other
Page Range:
359–364
Online Publication Date:
01 Feb 1998
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We have previously reported that corticotropin-releasing factor (CRF) is a potent stimulator of adrenocorticotropic hormone and cortisol secretion in the dog. Therefore, in the present study, we investigated the extrahypophysiotropic actions of CRF in this species. When CRF was injected into the third cerebral ventricle, it failed to inhibit food intake significantly at doses of 1.19, 3.57, and 11.9 nmol. This is in sharp contrast with the results in rodents. At the 3.57 and 11.9 nmol doses, CRF markedly stimulated the secretion of pancreatic polypeptide (PP), a hormone under vagal control, and at the highest dose CRF increased plasma glucose levels. These results suggest species differences in the feeding response to CRF and activation of the parasympathetic nervous system in the dog.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
6
Article Type:
Other
Print Publication Date:
01 Feb 1998
Online Publication Date:
01 Feb 1998