Opposite effects of feeding a vitamin A-deficient diet and retinoic acid treatment on brown adipose tissue uncoupling protein 1 (UCP1), UCP2 and leptin expression

in Journal of Endocrinology
Authors:
ML Bonet
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J Oliver
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C Pico
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F Felipe
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J Ribot
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S Cinti
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A Palou
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DOI:
https://doi.org/10.1677/joe.0.1660511
Volume/Issue:
Volume 166: Issue 3
Article Type:
Other
Page Range:
511–517
Online Publication Date:
01 Sep 2000
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The relationship between interscapular brown adipose tissue (IBAT) thermogenic potential and vitamin A status was investigated by studying the effects of feeding a vitamin A-deficient diet and all-trans retinoic acid (tRA) treatment on body weight and IBAT parameters in mice. Feeding a vitamin A-deficient diet tended to trigger opposite effects to those of tRA treatment, namely increased body weight, IBAT weight, adiposity and leptin mRNA expression, and reduced IBAT thermogenic potential in terms of uncoupling protein 1 (UCP1) mRNA and UCP2 mRNA expression. The results emphasize the importance of retinoids as physiological regulators of brown adipose tissue.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
7
Article Type:
Other
Print Publication Date:
01 Sep 2000
Online Publication Date:
01 Sep 2000