Retinoid nutritional status differently affects the expression of Japanese quail retinoic acid receptor-beta isoform transcripts in a tissue-specific manner

in Journal of Endocrinology
Authors:
ZW Fu
Search for other papers by ZW Fu in
Current site
Google Scholar
PubMed Close
,
T Kubo
Search for other papers by T Kubo in
Current site
Google Scholar
PubMed Close
,
K Sugahara
Search for other papers by K Sugahara in
Current site
Google Scholar
PubMed Close
,
T Noguchi
Search for other papers by T Noguchi in
Current site
Google Scholar
PubMed Close
, and
H Kato
Search for other papers by H Kato in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.1677/joe.0.1690281
Volume/Issue:
Volume 169: Issue 2
Article Type:
Other
Page Range:
281–290
Online Publication Date:
01 May 2001
Free access

Sign up for journal news

We investigated the effects of vitamin A (VA) nutritional status on the levels of expression of retinoic acid (RA) receptor-beta (RARbeta) gene in the various tissues of Japanese quail. VA deficiency caused a significant decrease in the mRNA levels of brain, liver, heart, lung and kidney RARbeta2/beta4, whereas no change was observed in the level of testis RARbeta2 transcript. In contrast, reduction in the RARbeta1 transcript caused by VA depletion was observed only in the lung, remaining unchanged in the other tissues. The administration of RA to the VA-deficient quail rapidly induced the expression of RARbeta2/beta4 mRNAs in all the tissues examined, but RA increased the expression of RARbeta1 transcript in the liver, heart, lung and kidney at a lower magnitude. RA could not change the expression of the brain RARbeta1 transcript, while it induced the expression of the testis RARbeta1 mRNA in a temporal way. These results clearly indicate that VA nutritional status differently regulates the expression of RARbeta1 and RARbeta2/beta4 transcripts in a tissue-specific manner.

Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 180 109 4
PDF Downloads 83 31 5

 

  • Collapse
  • Expand
Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
10
Article Type:
Other
Print Publication Date:
01 May 2001
Online Publication Date:
01 May 2001