Gap junction proteins and cell-cell communication in the three functional zones of the adrenal gland

in Journal of Endocrinology
Authors:
KT Davis
Search for other papers by KT Davis in
Current site
Google Scholar
PubMedClose
,
N Prentice
Search for other papers by N Prentice in
Current site
Google Scholar
PubMedClose
,
VL Gay
Search for other papers by VL Gay in
Current site
Google Scholar
PubMedClose
, and
SA Murray
Search for other papers by SA Murray in
Current site
Google Scholar
PubMedClose
View More View Less
DOI:
https://doi.org/10.1677/joe.0.1730013
Volume/Issue:
Volume 173: Issue 1
Article Type:
Other
Page Range:
13–21
Online Publication Date:
01 Apr 2002
Free access

Mouse and monkey adrenal glands were used to study the relationships between gap junction protein expression, intercellular communication and adrenal zonation. Dye communication patterns were determined by incubating freshly excised and hemisected adrenal glands in Lucifer yellow, a gap junction permeable fluorescent dye. Immunohistochemical techniques were used to localize adrenal gap junction proteins. The combination of these two techniques permitted the correlation of gap junction proteins with dye transfer and hormone responses in specialized regions of the adrenal cortex. Lucifer yellow dye communication was most pronounced in the inner glucocorticoid/androgen-producing regions (zona fasciculata/zona reticularis), but was virtually absent in the outer mainly mineralocorticoid-producing region (zona glomerulosa). This pattern of dye communication was coincident with immunohistochemical localization of the gap junction protein, alpha(1)Cx43. The variations in communication and alpha(1)Cx43 expression within the adrenal cortex are thought to be relevant to normal physiological regulation of the adrenal gland.

Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 71 65 1
PDF Downloads 66 64 12

 

  • Collapse
  • Expand
Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
9
Article Type:
Other
Print Publication Date:
01 Apr 2002
Online Publication Date:
01 Apr 2002