Photoperiod-dependent regulation of inhibin in Siberian hamsters: I. Ovarian inhibin production and secretion

in Journal of Endocrinology
Authors:
HA Kenny
Search for other papers by HA Kenny in
Current site
Google Scholar
PubMedClose
,
DJ Bernard
Search for other papers by DJ Bernard in
Current site
Google Scholar
PubMedClose
,
TH Horton
Search for other papers by TH Horton in
Current site
Google Scholar
PubMedClose
, and
TK Woodruff
Search for other papers by TK Woodruff in
Current site
Google Scholar
PubMedClose
View More View Less
DOI:
https://doi.org/10.1677/joe.0.1740071
Volume/Issue:
Volume 174: Issue 1
Article Type:
Other
Page Range:
71–83
Online Publication Date:
01 Jul 2002
Free access

Follicle-stimulating hormone (FSH) stimulates ovarian follicle development and the production of protein hormones including inhibin A and inhibin B. The inhibins are dimeric proteins (alpha-beta(A) or alpha-beta(B)) secreted by growing follicles that suppress FSH in a classical endocrine negative feedback loop. Siberian hamsters, Phodopus sungorus, exhibit seasonal variation in FSH levels. Given the role of inhibin in FSH regulation, we hypothesized that ovarian inhibin expression differs between animals reared in long (16 h light:8 h darkness) and short (6 h light:18 h darkness) photoperiods. To examine inhibin expression in animals housed under long or short photoperiods, hamster inhibin alpha-, beta(A)-, and beta(B)-subunits were cloned and used to detect and localize inhibin subunit mRNA in developing follicles. Ovarian inhibin alpha-subunit mRNA levels were significantly higher in long day-exposed (LD) than in short day-exposed (SD) hamsters. In addition, dimeric inhibin, as well as inhibin alpha-, beta(A)-, and beta(B)-subunit protein levels were higher in the LD than in the SD hamster ovaries.

Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 83 74 0
PDF Downloads 46 43 1

 

  • Collapse
  • Expand
Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
13
Article Type:
Other
Print Publication Date:
01 Jul 2002
Online Publication Date:
01 Jul 2002