Changes of endothelin in streptozotocin-induced diabetic rats: effects of an angiotensin converting enzyme inhibitor, enalapril maleate

in Journal of Endocrinology
Authors:
Y Itoh
Search for other papers by Y Itoh in
Current site
Google Scholar
PubMed Close
,
S Imamura
Search for other papers by S Imamura in
Current site
Google Scholar
PubMed Close
,
K Yamamoto
Search for other papers by K Yamamoto in
Current site
Google Scholar
PubMed Close
,
Y Ono
Search for other papers by Y Ono in
Current site
Google Scholar
PubMed Close
,
M Nagata
Search for other papers by M Nagata in
Current site
Google Scholar
PubMed Close
,
T Kobayashi
Search for other papers by T Kobayashi in
Current site
Google Scholar
PubMed Close
,
T Kato
Search for other papers by T Kato in
Current site
Google Scholar
PubMed Close
,
M Tomita
Search for other papers by M Tomita in
Current site
Google Scholar
PubMed Close
,
A Nakai
Search for other papers by A Nakai in
Current site
Google Scholar
PubMed Close
,
M Itoh
Search for other papers by M Itoh in
Current site
Google Scholar
PubMed Close
, and
A Nagasaka
Search for other papers by A Nagasaka in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.1677/joe.0.1750233
Volume/Issue:
Volume 175: Issue 1
Article Type:
Other
Page Range:
233–239
Online Publication Date:
01 Oct 2002
Free access

Sign up for journal news

Endothelin-1 (ET-1) concentrations are increased in patients with diabetes mellitus, particularly those with diabetic retinopathy, or essential hypertension. We hypothesized that ET-1 might participate in the development and progression of diabetic microangiopathy. In this study, the effects of the angiotensin converting enzyme (ACE) inhibitor, enalapril maleate, on diabetic angiopathy were examined in streptozotocin (STZ)-induced diabetic (STZ-DM) rats by monitoring variations in renal function and ET-1 concentrations in blood and organ tissues. Significant increases in kidney weight and in concentrations of urinary albumin, N-acetyl-fl-d-glucosamidase (NAG) and serum ET-1 were observed in the STZ-DM rats as compared with the non-diabetic rats, and the concentration of ET-1 in the kidneys tended to be increased. Microscopic and electron microscopic analyses showed increased mesangial cell proliferation, matrix expansion and enlarged mesangial area in the kidney of the diabetic rats. After administration of the ACE inhibitor, increased concentrations of urinary albumin and NAG in the STZ-DM rats were reduced to the control values with a slight improvement in the electron microscopic changes. These data suggest that ET-1 may be involved in the development and progression of diabetic nephropathy and may explain, in part, why diabetes is liable to complicate hypertension. ACE inhibitor may help to restore diabetic nephropathy in the STZ-induced diabetic rats.

Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 202 100 2
PDF Downloads 102 37 4

 

  • Collapse
  • Expand
Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
7
Article Type:
Other
Print Publication Date:
01 Oct 2002
Online Publication Date:
01 Oct 2002