Reductions in adipose tissue and skeletal growth in rat adult offspring after prenatal leptin exposure
in Journal of EndocrinologySearch for other papers by C Nilsson in
Current site
Google Scholar
PubMed
Search for other papers by D Swolin-Eide in
Current site
Google Scholar
PubMed
Search for other papers by C Ohlsson in
Current site
Google Scholar
PubMed
Search for other papers by E Eriksson in
Current site
Google Scholar
PubMed
Search for other papers by HP Ho in
Current site
Google Scholar
PubMed
Search for other papers by P Bjorntorp in
Current site
Google Scholar
PubMed
Search for other papers by A Holmang in
Current site
Google Scholar
PubMed
Leptin is involved in regulating food intake, energy balance and bone formation. Increasing evidence suggests that leptin is also involved in fetal growth and development. The aim of this study was to determine if increased maternal leptin is followed by changes in body composition, skeletal growth or hormonal regulation in the adult rat offspring. Pregnant rats were given injections of either human recombinant leptin (3.5 mg/kg, i.p.) or vehicle on days 8, 10 and 12 of gestation. Both genders of leptin-exposed offspring showed significantly reduced adipose tIssue weight at adult age. Skeletal growth and cortical bone dimensions were significantly reduced. Circulating testosterone levels were significantly increased in female leptin-exposed offspring, and male leptin-exposed offspring had significant testicular enlargement. No significant effects were seen on circulating leptin levels or hypothalamic protein levels of the leptin receptor. The results demonstrate that maternally administered leptin is involved in fetal growth and development, leading to lean offspring with reduced skeletal growth.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 301 | 165 | 16 |
| PDF Downloads | 109 | 45 | 2 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519