TSH stimulates leptin secretion by a direct effect on adipocytes

in Journal of Endocrinology
Authors:
C Menendez
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R Baldelli
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JP Camina
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B Escudero
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R Peino
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C Dieguez
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FF Casanueva
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DOI:
https://doi.org/10.1677/joe.0.1760007
Volume/Issue:
Volume 176: Issue 1
Article Type:
Other
Page Range:
7–12
Online Publication Date:
01 Jan 2003
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Leptin is a circulating hormone secreted by adipose tIssue which acts as a signal to the central nervous system where it regulates energy homeostasis and neuroendocrine processes. Although leptin modulates the secretion of several pituitary hormones, no information is available regarding a direct action of pituitary products on leptin release. However, it has been pointed out that leptin and TSH have a coordinated pulsatility in plasma. In order to test a direct action of TSH on in vitro leptin secretion, a systematic study of organ cultures of human omental adipose tIssue was performed in samples obtained at surgery from 34 patients of both sexes during elective abdominal surgery. TSH powerfully stimulated leptin secretion by human adipose tIssue in vitro. In contrast, prolactin, ACTH, FSH and LH were devoid of action. These results suggest that leptin and the thyroid axis maintain a complex and dual relationship and open the possibility that plasmatic changes in TSH may contribute to the regulation of leptin pulses.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
6
Article Type:
Other
Print Publication Date:
01 Jan 2003
Online Publication Date:
01 Jan 2003