Regulation of estrogen receptor-alpha expression in MCF-7 cells by taxol

in Journal of Endocrinology
Authors:
MB Martin
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,
SV Angeloni
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,
P Garcia-Morales
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PF Sholler
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MD Castro-Galache
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JA Ferragut
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, and
M Saceda
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DOI:
https://doi.org/10.1677/joe.0.1800487
Volume/Issue:
Volume 180: Issue 3
Article Type:
Other
Page Range:
487–496
Online Publication Date:
01 Mar 2004
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Results presented in this study demonstrate that treatment of MCF-7 cells with taxol resulted in induction of estrogen receptor-alpha (ER alpha) gene transcription with a subsequent increase in ER alpha mRNA; this effect was promoter specific since taxol did not affect total transcription in MCF-7 cells and lacked an effect on transcription of the human acidic ribosomal phosphoprotein protein PO, progesterone receptor, and pS2 genes. In contrast to the increase in transcription of the ER alpha gene, taxol inhibited translation of the ER alpha mRNA. This effect is also transcript specific since taxol did not alter total protein synthesis and did not affect the concentration of progesterone receptor protein in the cell. The overall result of taxol treatment was to decrease the concentration of ER alpha protein in the MCF-7 cells. Evidence is presented that the effects of taxol on ER alpha gene transcription may be mediated through the induction of p53.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
10
Article Type:
Other
Print Publication Date:
01 Mar 2004
Online Publication Date:
01 Mar 2004