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Forced internal desynchrony induces cardiometabolic alterations in adult rats

in Journal of Endocrinology
Authors:
Isis Gabrielli Barbieri de Oliveira Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Marcos Divino Ferreira Junior Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Paulo Ricardo Lopes Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Dhiogenes Balsanufo Taveira Campos Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Marcos Luiz Ferreira-Neto Departament of Physiology, Institute of Biomedical Science, Laboratory of Electrophysiology and Cardiovascular Physiology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil

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Eduardo Henrique Rosa Santos Departament of Physiology, Institute of Biomedical Science, Laboratory of Electrophysiology and Cardiovascular Physiology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil

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Paulo Cezar de Freitas Mathias Department of Biotechnology, Genetics and Cell Biology, Laboratory of Secretion Cell Biology, State University of Maringá, Maringá, Paraná, Brazil

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Flávio Andrade Francisco Department of Biotechnology, Genetics and Cell Biology, Laboratory of Secretion Cell Biology, State University of Maringá, Maringá, Paraná, Brazil

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Bruna Del Vechio Koike Medical Department, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil

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Carlos Henrique de Castro Department of Physiological Science, Integrative Laboratory of Cardiovascular and Neurological Pathophysiology, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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André Henrique Freiria-Oliveira Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Gustavo Rodrigues Pedrino Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Rodrigo Mello Gomes Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Daniel Alves Rosa Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil

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Correspondence should be addressed to D A Rosa: danielr@ufg.br
DOI:
https://doi.org/10.1530/JOE-19-0026
Volume/Issue:
Volume 242: Issue 2
Article Type:
Research Article
Page Range:
25–36
Online Publication Date:
Aug 2019
Copyright:
© 2019 Society for Endocrinology 2019
Restricted access
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Disruptions in circadian rhythms have been associated with several diseases, including cardiovascular and metabolic disorders. Forced internal desynchronization induced by a period of T-cycles of 22 h (T22 protocol) reaches the lower limit of entrainment and dissociates the circadian rhythmicity of the locomotor activity into two components, driven by different outputs from the suprachiasmatic nucleus (SCN). The main goal of this study was to evaluate the cardiovascular and metabolic response in rats submitted to internal desynchronization by T22 protocol. Male Wistar rats were assigned to either a control group subjected to a usual T-cycles of 24 h (12 h–12 h) or an experimental group subjected to the T22 protocol involving a 22-h symmetric light–dark cycle (11 h–11 h). After 8 weeks, rats subjected to the T22 exhibited desynchrony in their locomotor activity. Although plasma glucose and insulin levels were similar in both groups, desynchronized rats demonstrated dyslipidemia, significant hypertrophy of the fasciculate zone of the adrenal gland, low IRB, IRS2, PI3K, AKT, SOD and CAT protein expression and an increased expression of phosphoenolpyruvate carboxykinase in the liver. Furthermore, though they maintained normal baseline heart rates and mean arterial pressure levels, they also presented reduced baroreflex sensitivity. The findings indicate that circadian timing desynchrony following the T22 protocol can induce cardiometabolic disruptions. Early hepatic metabolism dysfunction can trigger other disorders, though additional studies are needed to clarify the causes.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Volume 242: Issue 2
Copyright:
© 2019 Society for Endocrinology 2019
Page(s):
12
Article Type:
Research Article
Received Date:
10 Apr 2019
Accepted Date:
09 May 2019
Print Publication Date:
01 Aug 2019
Online Publication Date:
Aug 2019
Keywords:
insulin resistance; circadian rhythms; metabolism; blood pressure; corticosteroids

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