OXYTOCIN AS A NEUROHYPOPHYSIAL HORMONE IN THE HOLOCEPHALIAN ELASMOBRANCH FISH, HYDROLAGUS COLLEI

in Journal of Endocrinology
Restricted access

SUMMARY

Two peptides with uterotonic activity have been isolated from the pituitary gland of a holocephalian elasmobranch fish: Hydrolagus collei. One of them had an amino acid composition compatible with that of oxytocin itself, and also had the pharmacological properties of this hormone. The other peptide which was present in much smaller amounts was basic by chromatography and had the pharmacological characteristics of [8-arginine]-oxytocin. It was not completely purified because of the small amount available, but its amino acid composition was in accord with that of vasotocin. The implications of the presence of oxytocin in such a primitive fish on the phylogeny, and hence probably the evolution, of neurohypophysial hormones are discussed.

 

      Society for Endocrinology

Related Articles

Article Information

Metrics

All Time Past Year Past 30 Days
Abstract Views 63 63 15
Full Text Views 112 112 1
PDF Downloads 49 49 0

Altmetrics

Cited By

PubMed

Google Scholar