Insights into isoform-specific mineralocorticoid receptor action in the hippocampus

in Journal of Endocrinology
Authors:
Carolina GaudenziC Gaudenzi, Neuro-Epigenetics Research Group, University of Bristol, Bristol, United Kingdom of Great Britain and Northern Ireland

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Karen Rosemary MifsudK Mifsud, Neuro-Epigenetics Research Group, University of Bristol, Bristol, United Kingdom of Great Britain and Northern Ireland

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Johannes ReulJ Reul, Neuro-Epigenetics Research Group, University of Bristol, Bristol, United Kingdom of Great Britain and Northern Ireland

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Correspondence: Johannes Reul, Email: Hans.Reul@bristol.ac.uk
DOI:
https://doi.org/10.1530/JOE-22-0293
Volume/Issue:
Accepted Manuscripts
Article Type:
Review Article
Article ID:
JOE-22-0293
Online Publication Date:
01 May 2023
Copyright:
© 2023 The authors 2023
Open access

The mineralocorticoid receptor (MR) plays a critical role in the mammalian brain as a mediator of appropriate cellular and behavioural responses under both baseline and stressful conditions. In the hippocampus, the MR has been implicated in several processes, such as neuronal maintenance, adult neurogenesis, inhibitory control of the hypothalamic-pituitary-adrenal (HPA) axis, and learning and memory. Because of its high affinity for endogenous glucocorticoid hormones, the MR has long been postulated to mediate tonic actions in the brain, but more recent data have expanded on this view, indicating that the MR elicits dynamic responses as well.

The complexity of the diverse molecular, cellular, and physiological functions fulfilled by the human, rat and mouse MR could at least partially be explained by the existence of different isoforms of the receptor. The structural and functional characteristics of these isoforms, however, have remained largely unexplored. The present article will review the current knowledge concerning human, rat and mouse MR isoforms, and evaluate seminal studies concerning the roles of the brain MR, with the intent to shed light on the function of its specific isoforms.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© 2023 The authors 2023
Article ID:
JOE-22-0293
Article Type:
Review Article
Received Date:
03 Nov 2022
Rev-recd:
16 May 2023
Accepted Date:
26 May 2023
Print Publication Date:
May 2023
Online Publication Date:
01 May 2023